Osteosarcoma Metastatic to the Kidneys Without Lung Involvement

Ogose, Akira; Morita, Tetsuro; Emura, Iwao; Nemoto, Keiichi; Hirata, Yasuharu

doi:10.1093/jjco/29.8.395

Cited by 12 publications

(12 citation statements)

References 11 publications

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“…Its clinical symptoms, sometimes insidious, can delay diagnosis. The clinical features, the chronology of the lesions, a good tumor sampling and immunohistochemistry (cytokeratin AE1/AE3) can help in the differentiation between a carcinoma and a sarcoma of the kidney [7,[23][24][25]. Our case of an elderly patient presenting with total hematuria, which eventually led to the diagnosis of a high-grade primary renal osteoblastic osteosarcoma, is the 28th case of primary renal osteosarcoma reported in the literature and underlines the need of an early diagnosis of this highly malignant tumor.…”

Section: Discussionmentioning

confidence: 99%

Primary renal osteosarcoma: A case report

Ahomadegbé

Bennani-Guebessi

Karkouri

2014

African Journal of Urology

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Primitive renal osteosarcoma is a rare sarcoma of the kidney with only 27 cases reported in the literature. Its histogenesis is poorly understood. It occurs at an older age between the fifth and seventh decade of life with a male predominance. The clinical features are similar to other renal diseases. Imaging shows calcifications within a lumbar or flank mass. Histology describes a sarcomatous proliferation producing osteoid, most often at an advanced stage (pT4), which implies a poor prognosis. We report on the clinical and pathologic features of a case of primary renal osteosarcoma in a 56-year-old man with stage IV disease. This is the 28th case of primitive renal osteosarcoma reported in the literature, confirming the highly malignant nature of this tumor and the need for early diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary renal osteosarcoma: A case report

Ahomadegbé

Bennani-Guebessi

Karkouri

2014

African Journal of Urology

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“…Des cas d'ostéosarcomes métastatiques au niveau du rein ont été signalés et il est important de pratiquer un bilan osseux complet pour élimi-ner cette possibilité diagnostique 8,9 . Le pronostic est très mauvais; il rejoint celui des autres sarcomes du rein.…”

Section: Discussionunclassified

Ostéosarcome primitif du rein avec évolution métastatique au foie.Étude de cas et revue de la littérature

Gharbi

Trabelsi

Hochlef

et al. 2013

CUAJ

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L’ostéosarcome primitif du rein est une pathologie très rare dontl’histogénèse n’est pas claire. Les récidives locales et les métastasessont fréquentes et le pronostic est très mauvais. Nous décrivons icile cas d’une patiente de 59 ans qui présentait des douleurs lombairesgauches et un amaigrissement. Une échographie abdominaleet une tomodensitométrie abdominale ont révélé une masserétropéritonéale de 13 × 8 × 9 cm avec macrocalcifications. Lebilan d’extension n’a pas révélé d’autres lésions. On a procédé àune néphrectomie élargie gauche; l’examen histologique a révéléune prolifération tumorale constituée de cellules fusiformes de taillevariable, ces cellules manifestement atypiques produisant directementdu tissu ostéoïde évoquant un ostéosarcome rénal. Dix moisplus tard, la patiente présentait des lésions métastatiques au niveauhépatique sans autre lésion secondaire ni récidive locale. La patienteest actuellement en cours de traitement par chimiothérapie pardoxorubicine et cisplatine avec un recul de 17 mois. Les caractéristiquesanatomocliniques et les modalités thérapeutiques decette pathologie rare sont discutées ci-dessous.Primary osteosarcoma of the kidney is very rare. Its exact histogenesisremains unclear. It has a tendency to recur locally and metastasize,and the prognosis is very poor. We present a case of a59-year-old woman with left flank pain and weight loss. Abdominalultrasonography and bone scan revealed a large solid retroperitonealmass with calcifications. The patient underwent radicalnephrectomy; microscopic examination showed atypical cells withthe characteristic pattern of classic osteosarcoma with immatureneoplastic osteoid. Ten months later, the patient developedmetastatic lesions in the liver, without local recurrence or othersites of metastases. The patient is currently receiving chemotherapywith doxorubicin and cisplatin, with a follow-up in 17 months.The most important clinical findings, the pathogenesis and thetreatment modalities of this rare neoplasm are discussed.

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“…However, a more recent literature review found a mean interval of 62 months from time of treatment of primary tumor to diagnosis of renal metastases [12]. …”

Section: Discussionmentioning

confidence: 99%

Renal Metastases of a Femur Osteosarcoma: A Case Report and a Review of the Literature

Akasbi

Arifi

Lahlaidi

et al. 2012

Case Reports in Urology

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This paper discusses a rare case of renal metastatic osteosarcoma. A 25-year-old man with a history of metastatic osteosarcoma involving his right kidney was referred to our institution for treatment. He was managed with chemotherapy. An exhaustive review of the English literature pertaining to this disease was performed. To our knowledge, this case represents only the sixteenth. The literature suggests that the incidence of renal involvement in osteosarcoma is significant and that the treatment should be multidisciplinary in such patients.

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Osteosarcoma Metastatic to the Kidneys Without Lung Involvement

Cited by 12 publications

References 11 publications

Primary renal osteosarcoma: A case report

Primary renal osteosarcoma: A case report

Ostéosarcome primitif du rein avec évolution métastatique au foie.Étude de cas et revue de la littérature

Renal Metastases of a Femur Osteosarcoma: A Case Report and a Review of the Literature

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