Osteosarcoma of the breast

Anani, P; Baumann, R. P.

doi:10.1007/bf00542848

Cited by 16 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among 12 patients treated with surgical resection alone 8 died of progressive tumours with a median survival of 12 months after diagnosis [13,27,28,30,31,[33][34][35]. In addi tion all 4 patients treated with postoperative radiation therapy died of progressive disease [27,30,33,34]. Six patients in cluding our own had received combination chemotherapy [15,28,29,32,36].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…It appears therefore impor tant to look at the role of adjuvant chemotherapy in the treat ment of primary osteosarcoma of the breast. Based on data in the literature at least 9 of 18 patients had developed metas tatic disease, predominantly pulmonary metastases [13,[27][28][29][30][31][33][34][35]. Among 12 patients treated with surgical resection alone 8 died of progressive tumours with a median survival of 12 months after diagnosis [13,27,28,30,31,[33][34][35].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

See 1 more Smart Citation

Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

1995

View full text Add to dashboard Cite

Background: Extraosseous osteosarcoma is a rare disease with approximately 150 cases reported in the literature. Primary osteogenic sarcoma of the breast is considered a particularly rare localisation. Approximately 20 cases of osteogenic sarcoma of the breast have been reported in the literature. The radiographic findings of the primary lesion are often misinterpreted as benign fibroadenomas the diagnosis of this rare disease is based on histological criteria. Osteogenic sarcomas of the breast have a high tendency towards local recurrences early haematogenous pread particularly pulmonary metastases. Case Report: Osteogenic sarcoma of the breast was diagnosed in a 48-year-old woman. Following mastectomy axillary lymph node dissection the patient developed liver thoracic wall metastases. She obtained a complete remission to COSS-86 chemotherapy but subsequently relapsed died from disseminated tumour despite repeated surgical attempts postoperative radiotherapy palliative chemotherapy 24 months after the primary diagnosis. Conclusions: Based on the currently available data of the cases reported radical resection of the primary tumour including axillary lymph node dissection is probably the appropriate surgical approach for primary osteogenic sarcoma of the breast. Since chemosensitivity of this malignancy has been observed adjuvant treatment according to the regimens employed for the treatment of osteogenic sarcoma of the bone (COSS treatment protocol) is recommended in order to improve the otherwise poor prognosis of patients with osteogenic sarcoma of the breast.

show abstract

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

1995

View full text Add to dashboard Cite

show abstract

“…The malignant mixed mesodermic tumour is basically a sarcoma or carcinosareoma consisting of a multi-potent cellular stroma and indistinct areas of chondroblastie, osteoblastie, lipoblastic or rhabdomyoblastic differentiation. Nonetheless, their existence has not been reported in the human breast (Angerwall et al, 1973) and the osteosarcoma is one of the rarest tnmours of this gland (Anani and Baumann, 1972). Extraskeletal malignant tumours, like the chondrosarcoma or inyxoid chondrosarcoma, possess a definite clinical and pathological particularity.…”

Section: Commentsmentioning

confidence: 99%

“…Its histogenesis is still a matter of debate, and most of its various possibilities have been recently discussed (Anani and Baumann, 1972). Its histogenesis is still a matter of debate, and most of its various possibilities have been recently discussed (Anani and Baumann, 1972).…”

Section: Commentsmentioning

confidence: 99%

Malignant mixed osteogenic tumours of the breast

Llombart‐Bosch¹,

Peydro²

1975

Virchows Arch. A Path. Anat. and Histol.

View full text Add to dashboard Cite

Two cases of malignant mesodermic tumours of the human mammary gland with osteogenic and chondrogenic structures were analysed by optical and electronic microscopical means. One of them was associated with an adenocarcinoma of the gland. The histological pattern was similar to that of those cases previously examined under the optical microscope in the mammary gland and in extraskeletal osteogenic sarcomas of soft tissues. When investigated under the electron microscope, the chondroblasts possessed a highly developed RER in active synthesis with an amorphous material which contributed to the building up of the ground substance matrix of the tumorous cartilage. Osteoid fields with scattered osteoblasts appear throughout the tumorous stroma and were associated with calcium deposits. They were continuous with fibroblasts and mesenchymal undifferentiated cells of a very immature character. Giant cells of osteoclastic type were included within the mononucleated mesenchymal cells mimicking bone osteoclastoma. The presence of all these cell types suggests the existence of a common malignant origin, the stem cell being differentiated into epithelial carcinomatous and mesenchymal sarcomatous chondral and osteogenic tissues.

show abstract

“…Many of the reported mammary osteosarcomas were described in association with a biphasic tumor (fibroadenoma, cystosarcoma phyllodes or carcinosarcoma). [5][6][7][8][9][10][11][12][13][14][15][16][17][18] The precise frequency of these neoplasms is difficult to determine. Nevertheless, approximately 200 reported cases of pure osteosarcoma of the breast, unassociated with a biphasic neoplasm, had been published up to 1998, 19 as well as 12 cases that had been reported in Japan by 1989.…”

Section: Introductionmentioning

confidence: 99%