Osteosarcoma of the craniofacial bones

Vege, D. S.; Borges, Anita M.; Aggrawal, Kailash Chandra; Balasubramaniam, Ganesh Kumar; Parikh, Deepak M.; Bhaser, Bhajrang

doi:10.1016/s1010-5182(05)80614-6

Cited by 78 publications

(61 citation statements)

References 18 publications

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“…[1][2][3][4][5][6][7][8][9][10] The occurrence of osteosarcoma in the craniofacial bones peaks in the third decade, whereas that in the skeleton peaks in the second decade. 3,4,8,10) The etiology of osteosarcoma is unknown, but the major risk factors for development of osteosarcoma in craniofacial bones may be similar to those of the long skeletal bones, consisting of exposure to radiation, retinoblastoma, Li-Fraumeni syndrome, and Paget's disease. 3,4,9,10) The skull is a favored site for osteosarcoma arising out of Paget's disease.…”

Section: Discussionmentioning

confidence: 99%

“…6) The classic``sun ray'' or``sun burst'' appearance is also seen in 25% to 31% of patients. 8,10) Osteosarcoma can be classified histologically into three main subtypes: the chondroblastic, osteoblastic, and fibroblastic types (Table 2). 1,3,4,8) Osteoblastic tumors generally belong to the high-grade tumors (grade 3 or 4), whereas chondroblastic and fibroblastic osteosarcomas are usually either grade 1 or 2.…”

Section: Discussionmentioning

confidence: 99%

“…8,10) Osteosarcoma can be classified histologically into three main subtypes: the chondroblastic, osteoblastic, and fibroblastic types (Table 2). 1,3,4,8) Osteoblastic tumors generally belong to the high-grade tumors (grade 3 or 4), whereas chondroblastic and fibroblastic osteosarcomas are usually either grade 1 or 2. 3,4) Osteosarcoma was defined as low grade because osteosarcoma is a spindle-cell tumor associated with irregular bone production, low cellularity, fewer than 4 mitoses per 10 high-power fields, and absence of pronounced atypia.…”

Section: Discussionmentioning

confidence: 99%

“…5) However, there is no significant correlation between the histological grading Osteosarcoma of the Skull of osteosarcoma and the prognosis. [8][9][10] The presence of osteoids laid down by malignant stromal cells is regarded as the histological key feature of osteosarcoma. 8) The recommended treatment has not yet been established, but radical surgery for extirpation including a large margin of normal bone is the most significant factor contributing to a good outcome.…”

Section: Discussionmentioning

confidence: 99%

“…10) Osteosarcoma tends to occur in the long bones of the extremities, whereas only 5% to 6% arise in the craniofacial bones. 3,4,8,10) The vast majority of craniofacial osteosarcomas are located in the zygomatic bone, whereas tumors affecting the skull are rare. 2) We report a case of osteosarcoma of the parietooccipital bone and describe the radiological features, clinical symptoms, and surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

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Osteosarcoma Arising From the Skull. Case Report.

Kanazawa

Yoshida

Takahashi

et al. 2003

Neurol. Med. Chir.(Tokyo)

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A 20-year-old male presented with an osteosarcoma in the right parieto-occipital bone occurring as a painless occipital lump which had rapidly enlarged in the 6 months prior to admission. The neuroimaging appearance resembled intraosseous meningioma. Gross total resection of the tumor was achieved. The final histological diagnosis was osteosarcoma. Osteosarcomas of craniofacial region have a better prognosis than those of the skeletal bones, and distant metastasis is rare. Local recurrence is the most significant factor contributing to poor outcome. Complete excision with negative margins is the key to a better outcome. Adjuvant therapy may be an option in cases of incomplete excision. Advances in target chemotherapy may diminish the significant morbidity associated with these lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Osteosarcoma Arising From the Skull. Case Report.

Kanazawa

Yoshida

Takahashi

et al. 2003

Neurol. Med. Chir.(Tokyo)

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Head and neck osteosarcoma at the University of Washington

Oda¹,

Bavisotto²,

Schmidt³

et al. 1997

Head Neck

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Background Head and neck osteosarcoma is a comparatively rare and aggressive malignancy. Our goal was to examine the experience of head and neck osteosarcoma patients seen over a 15‐year period at the University of Washington Medical Center and compare this with the published experience of other centers in terms of demographics, histology, treatment, and survival rate. Methods We reviewed surgical pathology slides and clinical treatment records of 13 patients who were treated at the University of Washington Medical Center between 1981 and 1996. A total of 17 cases from 13 patients (13 primary tumors and 4 recurrences) were studied. Results There was a slight male predominance, with a male:female ratio of 1.6:1, and median age at diagnosis of 40.9 years (range 22 to 75 years), both slightly higher than has been generally reported. Three of 13 patients had recognized risk factors for the development of osteosarcoma: 2 with a history of prior radiotherapy and 1 with Paget's disease. All surgical pathology specimens were examined independently by two pathologists for histologic grading and typing. At initial presentation, 9/13 (69%) cases had conventional (osteoblastic) histology; 2/13 (15%) were fibroblastic, 1 chondroblastic (8%) and 1 parosteal (8%). Eight of 13 (62%) cases were high grade at initial presentation. Four of 13 (30%) of the primary tumors were low grade, 2 of which did not recur over a median follow‐up period of 24 months. The other 2 low‐grade tumors later recurred locally, as high‐grade osteosarcomas, after disease‐free intervals of 1 year and 14 years, respectively. One patient had an intermediate‐grade tumor which has not recurred as of last follow‐up. Combined‐modality treatment, including surgery with or without radiotherapy and/or chemotherapy, was given depending on the histologic grade, surgical margins, and recurrence. Some patients with low‐grade tumors had surgery only. There were 5 local recurrences, 1 of these following a disease‐free interval of 14 years. One patient had 3 separate recurrences at the same site. Ten of 13 (77%) are alive and disease‐free. Of the 3 deaths, 1 was related to radiation‐induced brain necrosis, without evidence of recurrent tumor. The projected 5‐year overall survival in this series is 72%, with a mean follow‐up of 58 months (median, 36 months). Of those receiving neoadjuvant chemotherapy, 6/7 have survived to the present. Conclusion Given the limitations of a small patient population, our data suggest that neoadjuvant chemotherapy may provide benefit in terms of survival. Longer follow‐up will be necessary to support this conclusion. Our data also show that our population has a higher‐than‐average age of onset, low presence of risk factors, and better survival rate in comparison with the published series from other institutions. © 1997 John Wiley & Sons, Inc. Head Neck 19:513–523, 1997.

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Primary osteosarcoma of the head and neck in pediatric patients

Gadwal

Gannon

Fanburg‐Smith

et al. 2001

Cancer

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BACKGROUND Primary osteosarcomas of the head and neck in the pediatric age group, not associated with previous irradiation or a known syndrome, are rare. The literature contains several single cases and small study series; however, to the authors's knowledge, there has been no comprehensive large study to evaluate the clinicopathologic aspects of these tumors. METHODS Twenty‐two cases of osteosarcomas of the head and neck in patients 18 years of age or younger, diagnosed between 1970 and 1997, were retrieved from the Otorhinolaryngic−Head & Neck Tumor Registry of the Armed Forces Institute of Pathology (AFIP). No secondary sarcomas (radiation‐induced or those arising after chemotherapy) or those associated with known syndromes were included. Clinical, radiographic, and histologic features were reviewed, and patient follow‐up was obtained. RESULTS The patients included 11 girls and 11 boys, 1–18 years of age (mean, 12.2 yrs). Patient symptoms related to tumor location were painless swelling, loss of teeth, headaches, or a mass lesion, present for an average of 5.9 months. No genetic abnormalities were documented. The tumors most frequently involved the mandible (n = 19), followed by the sphenoid sinus (n = 2) and the maxilla (n = 1). The tumors ranged in size from 1.1–10.0 cm (mean, 4.5 cm). All tumors were invasive and malignant by radiology and/or histology. The tumors were Grade 1 (n = 11), Grade 2 (n = 8), or Grade 3 (n = 3). All cases, except one chondroblastic osteosarcoma, were osteoblastic osteosarcomas. Thirteen patients underwent initial surgical resection with (n = 5) or without (n = 9) additional radiation and/or chemotherapy. The remaining 9 patients had an initial biopsy for diagnosis followed by surgery (n = 4) or surgery and radiation and/or chemotherapy (n = 5). Follow‐up was available for 19 patients: 13 were alive at last follow‐up with no evidence of disease (mean, 13.1 yrs); 1 was alive with disease (1.3 yrs); 3 had died without evidence of disease (mean, 23.2 yrs); and 2 had died of disease (mean, 7.8 yrs). The 3 patients with high‐grade osteosarcoma were alive without disease (mean, 20.0 yrs). CONCLUSIONS Primary head and neck osteosarcomas in the pediatric population are typically low‐ to moderate‐grade lesions in the mandible. Despite the invasive nature and high grade of a few of these tumors, there is an excellent overall long‐term prognosis for patients in this age group with tumors in these locations. Cancer 2001;91:598–605. © 2001 American Cancer Society.

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Osteosarcoma of the craniofacial bones

Cited by 78 publications

References 18 publications

Osteosarcoma Arising From the Skull. Case Report.

Osteosarcoma Arising From the Skull. Case Report.

Head and neck osteosarcoma at the University of Washington

Primary osteosarcoma of the head and neck in pediatric patients

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