Osteosarcoma of the jaws.Analysis of 56 cases

Abstract

Fifty‐six cases of osteosarcoma of the maxilla or mandible are analyzed for clinical, roentgenographic and histologic character, therapy and prognosis. The mean age at the onset of symptoms for osteosarcoma of the jaws is about a decade later than for osteosarcoma of other bones. Pain is less often associated with osteosarcoma in the jaws than it is in the long bones. Roentgenographic evidence of a symmetrically widened periodontal membrane space may be a significant early finding. There is no correlation between the histologic character of the tumors and prognosis but prognosis does appear to vary depending upon the specific site of origin within the bones. The worst prognosis is associated with maxillary antral osteosarcomas and mandibular symphysis osteosarcomas have the best prognosis. Radical surgery is the treatment of choice. Approximately one third of the patients had biopsy‐proved metastasis, with the lung being the most common site.

Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults

“…First, the median age is at least 2 decades higher 4. Second, although patients with extremity osteosarcoma have a very high risk of metastatic disease of the lungs (44% to 49%),5 pulmonary metastases are less common in patients with osteosarcoma of the head and neck (4% to 43%) 6, 7. Furthermore, local recurrences predominate in osteosarcoma of the head and neck with a reported incidence of 17% to 70%2, 8 compared with 5% to 7% in extremity osteosarcoma 5.…”

Chondroblastic osteosarcoma of maxilla: a case report and review of literature

“…Craniofacial osteosarcoma is a relatively rarer entity and osteosarcomas of the jaws (OSJ) constitute only about 6.5-7% of all osteosarcomas [3]. OSJ differs from OS of long bones in its biological behaviour, though they share common histological features.…”

“…The predominant histological variants described are osteoblastic, fibroblastic and chondroblastic varieties [10]. The jaw lesions are predominantly chondroblastic [2,3]. Although histopathological subtypes have not been shown to have prognostic significance [4], Broder's grading of the tumor based on the degree of cellular anaplasia is prognostically significant.…”

“…Although it is the most common malignancy of long bones after multiple myeloma [2], it is a relatively rarer entity in the craniofacial region. Craniofacial osteosarcomas constitute only about 6.5-7% of all osteosarcomas [3]. Despite sharing common histopathological features, Osteosarcoma of Jaw bones (OSJ) and Osteosarcoma of Long bones (OSL) are distinct biological entities.…”

Rare tumors of sinonasal track

“…The most effective single therapeutic measure appears to be radical resection. If palpable nodes are present, neck dissection does apparently improve survival [10]. CT scan was superior to conventional radiography, including panoramic radiography, for detecting the extent of bone destruction and new bone formation in the lesion, allowing more accurate evaluation of the osteosarcoma [11].…”