Osteosarcopenic obesity is associated with reduced handgrip strength, walking abilities, and balance in postmenopausal women

Ilich, Jasminka Z.; Inglis, Julia Ellen; Kelly, Owen; McGee, Dan

doi:10.1007/s00198-015-3186-y

Cited by 86 publications

(100 citation statements)

References 34 publications

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“…We showed recently that older women suffering from osteopenic obesity, sarcopenic obesity and/or osteosarcopenic obesity (as an ultimate fate of former two) were inferior in several of the functional performance measures, compared to their obese-only counterparts. Even more so, those suffering from osteosarcopenic obesity showed significantly poorer performance in handgrip strength, balance and walking speed, compared to each other group (Ilich et al 2015).…”

Section: :1mentioning

confidence: 86%

“…Recently, some researchers and fitness professionals used body fat of 32% as the cutoff for overweight/obesity in women , Wanner et al 2016. In other studies, the 35% body fat as a cutoff was used for obesity classification (Ilich et al 2015) and that of 33% and/or 38% showed adverse influence on various skeletal sites . With an increased awareness of body fat causing derangements at many levels, we recommend a lower cutoff for obesity for women, specifically, 32-35% of body fat, than currently proposed by WHO (40%).…”

Section: :1mentioning

confidence: 99%

“…This is lower than the current cutoff for obesity being set at 40% body fat for women (Dufour et al 2013). As discussed above, different researchers used different levels for obesity classification in women, depending on the studied population and parameters examined (Ilich et al 2015, Wanner et al 2016. Moreover, Bosch and coworkers identified a cutoff of 38.3% body fat in women as an inflection point where the slope of the relation between visceral fat and percent body fat increases significantly (Bosch et al 2015).…”

Section: Interaction Among Aging Tissuesmentioning

confidence: 99%

“…Although fat infiltration is also a normal aging process, its elevation in an obesogenic environment exacerbates other processes, like loss of bone or muscle. Therefore, osteosteatosis and myosteatosis, combined with age-related loss of bone and muscle mass, contribute even more to loss of bone and muscle strength and overall function (Visser et al 2003, Lang et al 2010, Domiciano et al 2013, Ilich et al 2015.…”

Section: :1mentioning

confidence: 99%

“…Furthermore, as shown recently, myosteatosis may lead to the development of disorders such as diabetes that also increases the risk of falls secondary to impaired vision and/or neuropathy (Lang et al 2010) and contributes to increased risk for fractures (Lang et al 2010, Hamrick et al 2016. This may help explain the increased risk of frailty in older adults, not just in those who suffer from osteosarcopenic obesity, but also in those with each of the underlying conditions, osteopenic obesity and/ or sarcopenic obesity (Domiciano et al 2013, Ilich et al 2015, as indicated in Fig. 2.…”

Section: :1mentioning

confidence: 99%

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Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Jafarinasabian

Inglis

Reilly

et al. 2017

Journal of Endocrinology

225

147

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Aging affects almost all physiological processes, but changes in body composition and body phenotype are most observable. In this review, we focus on these changes, including loss of bone and muscle and increase in body fat or redistribution of the latter, possibly leading to osteosarcopenic obesity syndrome. We also address low-grade chronic inflammation, prevalent in aging adults and a cause of many disorders including those associated with body composition. Changes in dietary intake and nutritional requirements of older individuals, that all may lead to some disturbances on tissue and organ levels, are discussed as well. Finally, we discuss the hormonal changes in the aging body, considering each of the tissues, bone, muscle and fat as separate endocrine organs, but yet in the continuous interface and communication with each other. Although there are still many unanswered questions in this field, this review will enable the readers to better understand the aging human body and measures needing to be implemented toward reducing impaired health and disability in older individuals.

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Section: :1mentioning

confidence: 86%

Section: :1mentioning

confidence: 99%

Section: Interaction Among Aging Tissuesmentioning

confidence: 99%

Section: :1mentioning

confidence: 99%

Section: :1mentioning

confidence: 99%

See 3 more Smart Citations

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Jafarinasabian

Inglis

Reilly

et al. 2017

Journal of Endocrinology

225

147

View full text Add to dashboard Cite

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Dysmobility Syndrome Independently Increases Fracture Risk in the Osteoporotic Fractures in Men (MrOS) Prospective Cohort Study

Buehring

Hansen

Lewis

et al. 2018

Journal of Bone and Mineral Research

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We proposed the term "dysmobility syndrome" (DS) to identify individuals with impaired musculoskeletal health, a risk factor for falls and fractures. Whether DS is associated with increased risk of incident fracture is unknown. The Osteoporotic Fractures in Men (MrOS) study enrolled 5994 men ages ≥65 years, between March 2000 and April 2002. We used baseline data to determine whether DS increased fracture risk, independent of the Fracture Risk Assessment Tool (FRAX). Men met DS criteria at baseline if they had three or more of the following: appendicular lean mass/height <7.26 kg/m , total body fat >30%, spine or hip T-score ≤ -2.5, grip strength <30 kg, gait speed <1.0 m/s, and one or more fall within 12 months. We examined whether baseline DS increased the risk of hip and major osteoporotic fractures (MOFs) over a median of 14 years (IQR, 9 to 15 years). Among 5834 men mean age 74 ± 6 years, 471 (8%) had DS and 635 (11%) experienced an MOF, including 274 (5%) hip fractures. Age (per SD increase) conferred an HR of 1.72 (95% CI, 1.59 to 1.86), DS conferred an HR of 3.45 (95% CI, 2.78 to 4.29) and FRAX calculated with BMD (per %) conferred an HR of 1.10 (95% CI, 1.08 to 1.11) for MOF. Prediction of MOF using the FRAX score provided a concordance value of 0.67 ± 0.012 (concordance values are mean ± SE). Concordance increased to 0.69 ± 0.012 by adding DS and to 0.70 ± 0.012 by adding DS and age to the multivariate model. Kaplan-Meier curves indicated that men with both DS and a FRAX risk above the National Osteoporosis Foundation (NOF) treatment thresholds had higher MOF (HR 6.23; 95% CI, 3.10 to 12.54) and hip (HR 7.73; 95% CI, 5.95 to 10.04) fracture risk than men with neither condition. We suggest further studies to determine the optimal criteria for DS, and to test DS as a predictor of falls and fractures, especially in women. © 2018 American Society for Bone and Mineral Research.

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Bone mineral density predicts posttransplant survival among hepatocellular carcinoma liver transplant recipients

Sharma

Parikh

Yu³

et al. 2016

Liver Transpl

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Hepatocellular carcinoma (HCC) is a common indication for liver transplantation (LT). Recent data suggest that body composition features strongly affect post-LT mortality. We examined the impact of body composition on post-LT mortality in patients with HCC. Methods: Data on adult LT recipients who received MELD exception for HCC between 2/29/02-12/31/13 and had CT scan anytime 6 months prior to LT were reviewed (N=118). All available CT scan DICOM (Digital Imaging and Communications in Medicine) files were analyzed using a semiautomated high throughput methodology with algorithms programmed in MATLAB®. Analytic morphomics measurements including dorsal muscle group (DMG) area, visceral and subcutaneous fat and bone mineral density (BMD) were taken at the bottom of the 11th thoracic vertebral level. Results: Thirty-two patients (28%) died during the median follow up of 4.4 years. Number of HCC lesions (HR=2.72; P<0.001), BMD (HR=0.90/HU; P=0.03), pre-LT loco-regional therapy (HR=0.34; P<0.001) and donor age (HR=1.05; P<0.001) were the independent predictors of post-LT mortality. DMG area did not affect post-LT survival. Conclusion: In addition to number of HCC lesions and pre-LT loco-regional therapy, low BMD, a surrogate for bone loss rather than DMG area, was independently associated with post-LT mortality in HCC patients. Bone loss may be an early marker of deconditioning that precedes sarcopenia and may affect transplant outcomes.

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Osteosarcopenic obesity is associated with reduced handgrip strength, walking abilities, and balance in postmenopausal women

Abstract: These findings indicate a poorer functionality in women presenting with OSO, particularly compared to OB women, increasing the risk for bone fractures and immobility from the combined decline in bone and muscle mass, and increased fat mass.

Cited by 86 publications

References 34 publications

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Dysmobility Syndrome Independently Increases Fracture Risk in the Osteoporotic Fractures in Men (MrOS) Prospective Cohort Study

Bone mineral density predicts posttransplant survival among hepatocellular carcinoma liver transplant recipients

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