Osteotomy of dorsally displaced malunited fractures of the distal radius: No loss of radiographic correction during healing with a minimally invasive fixation technique and an injectable bone substitute

Abramo, Antonio Carlos; Tägil, Magnus; Geijer, Mats; Kopylov, Philippe

doi:10.1080/17453670710015085

Cited by 27 publications

(28 citation statements)

References 23 publications

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“…The pain and quality of life also improved significantly to reach VAS 2.4 and DASH 20 at 1 year. All the follow-up results were similar to previous reported results using pure calcium phosphate paste (Norian SRS, Synthes GmbH, Switzerland) [68]. The HA/calcium sulfate material was replaced by bone over the follow-up time (FIGURE 5; 3 months and 1 year), and all osteotomies were classified as healed at 1 year.…”

Section: Wrist Osteotomiesmentioning

confidence: 54%

“…The HA/calcium sulfate material was replaced by bone over the follow-up time (FIGURE 5; 3 months and 1 year), and all osteotomies were classified as healed at 1 year. The pure calcium phosphate material used was considered by the authors to be an almost nonresorbable material [68] (FIGURE 6). They concluded that the biphasic material is a safe alternative to autogenous bone graft.…”

Section: Wrist Osteotomiesmentioning

confidence: 99%

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The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications

Nilsson

Zheng

Tägil

2013

Expert Review of Medical Devices

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Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future.

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Section: Wrist Osteotomiesmentioning

confidence: 54%

Section: Wrist Osteotomiesmentioning

confidence: 99%

The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications

Nilsson

Zheng

Tägil

2013

Expert Review of Medical Devices

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“…Concerning the use of a synthetic material, such products come with an inherent advantage of no donor site morbidity; however their use also come with a high cost of production and sometimes a potentially low, but real, risk of disease transmission. Abramo et al [18] evaluated 25 consecutive patients with a dorsal malunion after a distal radius fracture treated with corrective osteotomy using a dorsal approach. A TriMed buttress pin and a radial pin plate were used, and calcium phosphate mixture (Norian SRS) as bone substitute.…”

Section: Pain (Vas) Complicationsmentioning

confidence: 99%

“…Mesenchymal stem cells have been seen to differentiate into chondrocytes and osteoblasts driven by the primitive induction of the BMPs, which are members of the transforming growth factor-b. Preclinical effectiveness investigation on BMPs took to subsequent clinical introduction of the most powerful BMPs, BMP-2 and BMP-7 [18,19] . OP-1, which also goes under the name of recombinant BMP-7, has been known for its osteoinductive properties.…”

Section: Osteoconductive Bone Graft Substitutesmentioning

confidence: 99%

Corrective osteotomies of the radius: Grafting or not?

Mugnai¹,

Tarallo²,

Lancellotti³

et al. 2016

WJO

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osteotomies to provide the best evidence of the rule of bone grafting. METHODS:Our MEDLINE literature search included 280 studies using the following key words "Malunited distal radius fracture" and 150 studies using key words "Corrective osteotomy of the distal radius". Inclusion criteria were: Malunited distal radial, extra articular fracture, volar locking plate, use of iliac bone graft (cancellous or corticocancellous), non-use of bone graft. Twelve studies met the inclusion criteria. RESULTS:Seven of the 12 studies considered, described the use of a graft; the remaining five studies didn't use any graft. Type of malunion was dorsal in most of the studies. The healing time was comparable using the graft or not (mean 12.5 wk), ranging from 7.5 to 16 wk. The mean disabilities of the arm, shoulder and hand score improvement was 23 points both in the studies that used the graft and in those not using the graft. CONCLUSION:This review demonstrated that corrective osteotomy of extra-articular malunited fractures of the distal radius treated by volar locking plate does not necessarily require bone graft. Core tip: The aim of this study was to review the current literature regarding corrective osteotomies in malunion of the distal radius to provide the best evidence of the rule of bone graft. Author contributions: Mugnai R, Catani F and Adani R designed the research; Lancellotti E and Di Giovine E performed the research; Mugnai R, Tarallo L and Zambianchi F wrote the paper. Conflict-of-interest statement:The authors declare that they have no conflicts of interest concerning this article. SYSTEMATIC REVIEWS 128February 18, 2016|Volume 7|Issue 2|

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“…Norian SRS has the most peer-reviewed literature with accompanying Level I evidence. 13,59,61,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84] Preformed granules and blocks of calcium phosphate are composed of tricalcium phosphate and/or hydroxyapatite. They are manufactured using a high-temperature sintering process to produce a material with a highly crystalline structure and interconnecting porosity similar to bone.…”

Section: Resultsmentioning

confidence: 99%

Bone graft substitutes currently available in orthopaedic practice

Kurien

Pearson

Scammell

2013

The Bone & Joint Journal

202

168

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We reviewed 59 bone graft substitutes marketed by 17 companies currently available for implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to facilitate informed decision-making regarding their use in clinical practice. After critical analysis of the literature, only 22 products (37%) had any clinical data. Norian SRS (Synthes), Vitoss (Orthovita), Cortoss (Orthovita) and Alpha-BSM (Etex) had Level I evidence. We question the need for so many different products, especially with limited published clinical evidence for their efficacy, and conclude that there is a considerable need for further prospective randomised trials to facilitate informed decision-making with regard to the use of current and future bone graft substitutes in clinical practice.

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Osteotomy of dorsally displaced malunited fractures of the distal radius: No loss of radiographic correction during healing with a minimally invasive fixation technique and an injectable bone substitute

Cited by 27 publications

References 23 publications

The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications

The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications

Corrective osteotomies of the radius: Grafting or not?

Bone graft substitutes currently available in orthopaedic practice

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