Osthole, a Coumadin Analog from &lt;b&gt;&lt;i&gt;Cnidium monnieri&lt;/i&gt;&lt;/b&gt; (L.) Cusson, Ameliorates Nucleus Pulposus-Induced Radicular Inflammatory Pain by Inhibiting the Activation of Extracellular Signal-Regulated Kinase in Rats

Wu, Haixuan; Wang, Yimin; Xu, Hui; Wei, Ming Q.; He, Qiulan; Li, Meina; Sun, Leina; Cao, Minghui

doi:10.1159/000475599

Cited by 20 publications

(13 citation statements)

References 30 publications

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“…Osthole, a natural coumarin extract from the fruit of Cnidium monnieri (L.) [ 21 ], has several beneficial pharmacological properties, such as antiseizure [ 22 ], antiosteoporosis [ 23 ], and antitumour [ 24 ] activities. Recently, studies found that osthole attenuates chronic kidney failure by inhibition of inflammation [ 25 ]. It also suppresses acute inflammatory responses in acute mechanical brain injury and kidney injury [ 26 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Jin

Qian

et al. 2018

Mediators of Inflammation

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Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.

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Section: Introductionmentioning

confidence: 99%

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Jin

Qian

et al. 2018

Mediators of Inflammation

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“…Paeonol inhibits the production of NO, PGE2, and IL-6 induced by LPS via prevention of ERK activation in RAW264.7 macrophages. Meanwhile, paeonol decreased protein expression of iNOS and COX-2 and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, NO and PGE2, and increased production of IL-10 in rat paw exudates of rat model of carrageenan-evoked thermal hyperalgesia (50,79).…”

Section: Affect Purinergic Receptorsmentioning

confidence: 99%

“…The various classes of flavonoids differ in the level of oxidation and the pattern of substitution of the C ring, whereas individual compounds within a class differ in the pattern of substitution of the A and B rings (11). Flavonoids (41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55) in TCM play an important role in analgesia, and have high application value and prospect.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Studies showed that the natural coumarin osthole has a variety of pharmacological effects, such as anti-tumor, anti-convulsant, antiinflammatory, osteogenic, anti-hepatitis, neuroprotective, and analgesic activities, and has a obvious effect on nucleus pulposus-evoked pain by inhibiting overexpression of acid-sensitive ion channel 3 in rat dorsal root ganglion and inhibiting the activation of extracellular signal-regulated kinase in rats (49,50) Inhibit of glutamate receptor Glutamate receptors, which are the major excitatory neurotransmitter receptors in the brain and play an important role in analgesia, has different subtypes of glutamate receptors each of which can be divided into several subtypes, such as NMDA receptors (GluN1 to GluN3), AMPA receptors (GluA1 to GluA4), kainate receptors (GluK1 to GluK5), and mGlu receptors (mGluR1 to mGluR8). Almost all types of glutamate receptors are involved in the formation of hyperalgesia (51).…”

Section: Regulate Ion Channelsmentioning

confidence: 99%

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Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review

et al. 2018

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Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients’ suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on. Traditional Chinese medicine and its active ingredients have unique advantages in the treatment of pain for quite a long time, and many analgesic drugs directly or indirectly were isolatiedfrom Chinese medicine or natural products, such as Liu Suan Yan Hu Suo Yi Su Pian and aspirin. With the development and modernization of research on herbal medicine more and more studies have been conducted on the active ingredients and mechanisms of traditional Chinese medicine analgesics. However, no review has been done on analgesic active components and their mechanisms. In this paper, 81 active components with clear chemical structure and definite analgesic effects in vivo and in vitro of traditional Chinese medicine and mechanisms of action reported in recent literatures are reviewed and summarized to provide reference for clinical analgesia and analgesics research.

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“…Fructus Cnidii is the dried ripe fruit of Cnidium monnieri (L.) Cuss. with some pharmacological effects, such as sedative effect [8], hypnotic action [8], anti-nociceptive effect [9], anti-cancer [10], and anti-inflammation [11]. Radix Glycyrrhizae is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.…”

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confidence: 99%

Analgesic and Anti-Inflammatory Effects of Herbal Mixture Extracts in Mice

Chien¹,

Chuang²,

Lin³

et al. 2018

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Herbal mixture extracts (HME) comprised of Semen Sojae Nigrum, Fructus Cnidii, Radix Glycyrrhizae, and Cornu Cervi. Herein, we employed three mouse models, including hot-plate test, acetic acid (AA)-induced writhing test and AA-induced vascular permeability test, to determine analgesic and anti-inflammatory effects of HME. Results revealed that HME exhibited analgesic effects in hot-plate test and in AA-induced writhing test, as evidenced by increasing the latency to lick paws and decreasing AA-induced writhing counts, respectively. HME also significantly and dose-dependently decreased AA-induced vascular permeability, indicating HME exhibited anti-inflammatory effects. Similar improvement can be observed in aspirin treatment that used as positive control in this study. Most of medicinal effects of Fructus Cnidii are considered to attribute to coumarins, such as osthol (OST) and imperatorin (IMP) with several pharmacological activities. We then used OST and IMP as bioactive components in HME. The content of OST and IMP in HME was 3.57 ± 0.10 mg/g and 1.20 ± 0.02 mg/g, respectively, from three independent batches. Only OST possessed inhibitory effects in three mouse models, suggesting that OST may partially involve in protective effects of HME. These results demonstrated that HME has a potential on anti-analgesic effects and anti-inflammatory actions.

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Osthole, a Coumadin Analog from <b><i>Cnidium monnieri</i></b> (L.) Cusson, Ameliorates Nucleus Pulposus-Induced Radicular Inflammatory Pain by Inhibiting the Activation of Extracellular Signal-Regulated Kinase in Rats

Cited by 20 publications

References 30 publications

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review

Analgesic and Anti-Inflammatory Effects of Herbal Mixture Extracts in Mice

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