Osthole alleviates MPTP-induced Parkinson’s disease mice by suppressing Notch signaling pathway

Wang, Yu; Zhou, Yong; Wang, Xiang; Zhen, Fei; Chen, Rui; Geng, Deqin; Yao, Ruiqin

doi:10.1080/00207454.2019.1573171

Cited by 23 publications

(12 citation statements)

References 34 publications

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“…Our results showed a significant decrease in SOD, GSH-Px, and T-AOC contents, along with a marked increase in MDA contents, indicating oxidative stress. Osthole treatment resulted in a marked assuagement of oxidative stress by bringing the abnormal oxidant levels to nearly normal, thus confirming that osthole has promising antioxidant effects [27,28,34,61].…”

Section: Discussionmentioning

confidence: 85%

“…It is commonly called “She-Chuang-Zi,” which is derived from the dried fruit of Cnidium monnieri (Fructus cnidii) [26]. It has anti-inflammatory, anti-osteoporotic, anti-tumor [27], anti-oxidant, and anti-apoptotic properties [28], and is used in the management of allergies and asthma [29], inflammation, and vascular diseases [30]. In view of such eminent therapeutic potential, we hypothesized that osthole may prove to be an excellent alternative to synthetic drugs for the treatment of different ailments with special reference to tibial dyschondroplasia in chickens.…”

Section: Introductionmentioning

confidence: 99%

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Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens

Waqas

Wang

et al. 2019

Antioxidants

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Avian tibial dyschondroplasia affects fast growing broiler chickens accounting for almost 30% of leg ailments in broilers. The present project was designed to assess the efficacy of osthole against avian tibial dyschondroplasia (TD). Two hundred and forty chickens were equally allocated into control, TD and osthole groups (n = 80). The TD and osthole group chickens were challenged with tetramethylthiuram disulfide (thiram) at 50 mg/kg of feed from 4–7 days, followed by osthole administration at 20 mg/kg orally to the osthole group only from 8–18 days. Thiram feeding resulted in lameness, increased mortality, and decreased production parameters, alkaline phosphatase (ALP), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-PX) levels, along with significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA) levels, and growth plate size. Moreover, the genes and protein expressions of BMP-2 and RUNX-2 were significantly down-regulated in TD affected chickens (p < 0.05). Osthole administration showed promising results by alleviating lameness; increased ALP, SOD, T-AOC, and GSH-Px levels; and decreased the AST, ALT, and MDA levels significantly. It restored the size of the growth plate and significantly up-regulated the BMP-2 and RUNX-2 expressions (p < 0.05). In conclusion, the oxidative stress and growth plate anomalies could be assuaged using osthole.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens

Waqas

Wang

et al. 2019

Antioxidants

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“…Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic PD, which may negatively regulate the Notch signaling pathway, accelerate neural stem cell differentiation, and modulate the function and survival of differentiated dopaminergic neurons in PD [15]. Also, a previous study showed that osthole, a natural coumarin compound, reduced MPTP-induced PD in a mouse model by inhibiting the Notch signaling pathway [16]. e920846-9 Wnt proteins are required for basic cell developmental processes, including cell senescence, cell proliferation, and cell division.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of mRNA expression profiling in Parkinson’s Disease

Wang

2020

Med Sci Monit

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Departmental sources Background: Parkinson's disease (PD) is a degenerative neurologic disease. This study aimed to undertake bioinformatics analysis using the publicly available Gene Expression Omnibus (GEO) database to integrate mRNA expression data from patients with PD and to compare differentially expressed genes (DEGs) in tissue from the substantia nigra and whole blood from patients with PD and normal controls. Material/Methods: Integrated network analysis included GEO datasets to identify DEGs in the substantia nigra and whole blood of patients with PD. Bioinformatics analysis was used to identify the roles of the DEGs and included the development of protein-protein interaction (PPI) networks and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Expression levels of DEGs were validated using GSE100054. Results: In patients with PD, there were 1,076 upregulated DEGs and 1,075 down-regulated DEGs in the substantia nigra tissue, and 699 upregulated and 930 down-regulated DEGs in whole blood samples. The apoptotic process, the mitogen-activated protein kinase (MAPK) signaling pathway, the Wnt signaling pathway, and the Notch signaling pathway were significantly enriched in DEGs in the substantia nigra in PD. In both the substantia nigra and whole blood, the most common DEGs were significantly enriched in lysosomes, PD, Alzheimer's disease, Huntington's disease. SORT1 and CRYAB were the hub proteins in the network of the substantia nigra; PSMA1 and SDHA were the hub proteins in the network of whole blood in PD. Conclusions: DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways.

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“…Osthole was shown to attenuate Parkinson's disease symptoms in mice induced by 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP) through the suppression of the Notch signaling pathway [98]. Mei et al demonstrated that osthole had a protective effect against 6-hydroxydopamine (6-OHDA) induced ER stress and oxidative stress injuries in PC12 cells, which involved the AktiGSK-311 pathway [99].…”

Section: Neuroprotective Activitymentioning

confidence: 99%

Osthole: an overview of its sources, biological activities, and modification development

Sun

Zhang

2021

Med Chem Res

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Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and separation from plants or total synthesis. Plenty of experiments have suggested that osthole exhibited multiple biological activities covering antitumor, anti-inflammatory, neuroprotective, osteogenic, cardiovascular protective, antimicrobial, and antiparasitic activities. In addition, there has been some research done on the optimization and modification of osthole. This article summarizes the comprehensive information regarding the sources and modification progress of osthole. It also introduces the up-to-date biological activities of osthole, which could be of great value for its use in future research.

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Osthole alleviates MPTP-induced Parkinson’s disease mice by suppressing Notch signaling pathway

Cited by 23 publications

References 34 publications

Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens

Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens

Integrated analysis of mRNA expression profiling in Parkinson’s Disease

Osthole: an overview of its sources, biological activities, and modification development

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