Östrogenfeedback-Tests bei Frauen mit Larynxkarzinomen

Kleemann, D.; Kunkel, S; Bellin, Tobias

doi:10.1055/s-2007-997541

Cited by 3 publications

(4 citation statements)

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“…Additionally, the first clinical studies have been undertaken [8,23,29]. Similar studies also were conducted on a possible therapy with a testosterone substitute or a block of the 5α-reductase [14]. However, in most clinical trails, no benefit was seen for the patients [25,29].…”

Section: Discussionmentioning

confidence: 99%

“…They occur with an incidence of about 5 to 7 cases per 100,000 individuals each year [15], mainly affecting men between the ages of 55 and 65 years. The male-to-female ratio has been determined to range between 20 to 1 [6] and 32 to 1 [14]. In our clinic, of the 1,770 laryngeal carcinomas treated within the last 20 years, the proportion of male to female patients was 12.4 to 1.…”

Section: Introductionmentioning

confidence: 99%

“…It is known that androgens control the growth of the laryngeal muscles [11], while testosterone causes temporary hypertrophy of the squamous epithelium of the vocal cords [11]. On the other hand, some suggest that the paucity of laryngeal carcinomas in women results from some kind of a hormonal "protection" [14]. However, no concept has been offered about whether these effects are directly transmitted via hormone receptors in the mucosa or represent indirect effects.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Hagedorn¹,

Nerlich

2002

European Archives of Oto-Rhino-Laryngology

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There are significant differences in how laryngeal cancer affects the two genders, with cases occuring predominantly in males. This has been speculated to result from the different susceptibilities of the tumor cells to steroid sex hormones. Since the sex hormone action is mediated by specific cellular receptors, several previous studies have analyzed the presence of these sex-hormone receptors. However, the data on the receptor status for androgen, estrogen and progesterone receptors in laryngeal carcinomas are controversial. Since some authors have suggested antiandrogen or antiestrogen therapy as an adjuvant treatment for laryngeal carcinoma, we performed a comprehensive study using immunomorphological and biochemical techniques on both in-vivo and in-vitro tumor cells in order to clarify whether major sex-hormone receptors are present or not. We performed an immunohistochemical analysis on 13 patients with laryngeal carcinomas, 8 males and 5 females, using monoclonal antibodies against androgen, estrogen and progesterone receptors. In addition, the presence of estrogen and progesterone receptors was tested biochemically using an enzyme immune assay (EIA). Furthermore, we analyzed immunohistochemically the expression of the hormone receptors in five keratinocyte cell lines originating from laryngeal carcinomas. In all of our tumor samples, as well as in the five tumor cell lines tested, we did not detect any specific immunohistochemical staining for androgen, estrogen and progesterone receptors in the laryngeal carcinoma cells when compared to the positive controls of breast and prostate cancer samples. Similarly, the biochemical analysis did not demonstrate any significant amount of receptor protein in the analyzed cases. In conclusion, the absence of male and female sex-hormone receptors strongly argues against laryngeal carcinomas being sex-hormone-dependent tumors. Therefore, we do not see any rational indication to use a specific antiandrogen or antiestrogen therapy for the adjuvant treatment of laryngeal carcinomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Hagedorn¹,

Nerlich

2002

European Archives of Oto-Rhino-Laryngology

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“…[7,8] Many research teams focused on the fact that hormone receptors are expressed in hormone independent tissues. [9]…”

Section: Introductionmentioning

confidence: 99%

Sex hormones in head and neck cancer: Current knowledge and perspectives

Singh¹,

Kumar²,

Goel

et al. 2012

Clin Cancer Investig J

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Head and neck cancer (HNC) is an increasing problem worldwide. Oral carcinogenesis is a highly complex multifocal process. Molecular mechanisms contributing to initiation and progression of head and neck squamous cell carcinoma are still poorly known. Endocrine microenvironment is another imperative factor beside other well-documented risk factors like tobacco smoking, alcohol and infections in causing cancers of head and neck. These endocrine hormones play a role in tumor progression in case of cancers characteristically expressing sex hormone receptors, and it has been proven that these receptors also reside outside the sex organs in the larynx and lungs. However, the role of sex hormones in HNC is controversial, and few studies have been conducted to delineate their role in HNC. So, this review article is an attempt to draw an attention towards the potential role of sex hormones in pathogenesis of HNC and potential therapeutic modalities to prevent onset and progression of cancer.

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