Other Blood Group Antigens and Antibodies

Reid, Marion E.; Westhoff, Connie M.

doi:10.1016/b978-0-443-06981-9.50013-2

Cited by 5 publications

(6 citation statements)

References 149 publications

(79 reference statements)

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“…Anti-M is common in antenatal patients (even when the fetus is M-negative); however, there are few reports of potent IgG anti-M that is active at 37°C and causes HDFN. [ 1 ] This holds true for our first case. Although the anti-M antibody had IgG component which was reactive at 37°C it was not potent enough to cause HDN in the fetus.…”

Section: Discussionsupporting

confidence: 63%

“…In adults, anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C. [ 1 ] It is usually clinically insignificant but can be active rarely at 37°C because of thermal amplitude of IgM component or presence of IgG component. It can cause or delayed hemolytic transfusion reactions or hemolytic disease of newborn.…”

Section: Introductionmentioning

confidence: 99%

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Report of two cases of anti-M antibody in antenatal patients

Philip¹,

Kushwaha²,

Jain³

2015

Asian J Transfus Sci

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Anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C. It is usually clinically insignificant but can be active at 37°C because of thermal amplitude of IgM component or presence of IgG component. It can cause or delayed hemolytic transfusion reactions or hemolytic disease of newborn. At our center we have encountered two cases of anti-M antibodies- one presenting as crossmatch incompatibility and other as blood grouping discrepancy in the last 8 months.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Report of two cases of anti-M antibody in antenatal patients

Philip¹,

Kushwaha²,

Jain³

2015

Asian J Transfus Sci

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“…Furthermore, cases related to anti-N are less common than anti-M. Anti-N is not clinically significant, and only a few studies have been reported to cause any haemolytic transfusion reaction or HDN (63). Anti-M alloimmunisation can be seen during delivery with severe late-onset anaemia due to haemolysis, whereas a combination with anti-MN related to HDN is rarely reported.…”

Section: Mnssmentioning

confidence: 99%

Haemolytic of Newborn Disease-Related Red Blood Cell Alloantibodies

Nahendran

Budin²,

Saat³

et al. 2022

Jurnal Teknologi

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Red cell alloimmunisation in pregnancy may result in haemolytic disease of the foetus and newborn (HDN). During pregnancy, there are possibilities of the foetal antigen being exposed to the mother’s circulation, thereby leading to the production of antibodies. The immunoglobulin G (IgG) antibodies from the mother pass through the maternal surface placenta, which is then sensitised and obstructs the formation of foetal red blood cells (RBCs). This review discusses the presence of variance alloantibodies during pregnancy, as well as the consequences of HDN and its management. This review revealed that ABO incompatibility is the most common cause of alloimmunisation in pregnancy. The Rh system (anti-D and -E) are the most common alloantibodies found in pregnant women, followed by other alloantibodies such as Kell, Duffy, Kidd and MNSs. Hyperbilirunemia (increased bilirubin levels) is commonly seen in neonatal jaundice due to HDN and it is usually manageable using the phototherapy method. Nevertheless, the clinical significance of alloantibodies can cause complications such as anaemia, and in some extreme cases, kernicterus might require a blood exchange transfusion.

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“…Не до ста так јед ног фре квент ног ан ти ге на или ви ше њих по ве зан је с рет ким фе но ти по ви ма. Од ли ке Гер бих ан ти те ла да те су у та бе ли 1 [10,11,12].…”

Section: трансфузиолошко збрињавање болесника с алоанти-гербих антителомunclassified

Transfusion management of patients with alloanti-Gerbich antibodies: Case report

et al. 2011

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In cases of emergency patients with alloantibodies against high frequency Gerbich, when autologous or compatible alogenous transfusion is unavailable, blood with the lowest positive cross-match reaction could be transfused if the biological cross-match is negative. Formation of a national register of donors with rare blood groups and their connection with international registers is of crucial significance in the management of patients requiring antigen negative blood otherwise unavailable from routine blood banks.

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Other Blood Group Antigens and Antibodies

Cited by 5 publications

References 149 publications

Report of two cases of anti-M antibody in antenatal patients

Report of two cases of anti-M antibody in antenatal patients

Haemolytic of Newborn Disease-Related Red Blood Cell Alloantibodies

Transfusion management of patients with alloanti-Gerbich antibodies: Case report

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