Introduction: Low back ache is the most common problem seen in orthopedic clinic. Low backache with lumbosacral radiculopathy remains the most challenging musculoskeletal problem for its therapeutic management. In around 90% patients, the cause of low back with radiculopathy is a prolapsed disc. Epidural steroid injections are used in the management of patients with subacute or chronic low backache with radiculopathy, not responding to conservative treatment. The aim of study was to check the efficacy of epidural steroid injection in patients of subacute or chronic low backache with radiculopathy due to herniated disc. Material and Methods: The study was conducted over 100 patients reporting to our OPD with chief complaints of LBA with radiculopathy, not responding to conservative treatment. Maximum of three epidural steroid injections were given with two weeks of interval in between. The patients were assessed before and after the procedure and assessment was done using VAS scoring system. Results: In our study, 80% patients got a significant improvement in symptoms according to VAS scoring system. Out of them, 70% improved with only a single dose of ESI, 20% with the second dose and the remaining 10% after third dose. Also the procedure was found to be more effective in treating patients of subacute low backache with radiculopathy rather than the chronic one. Conclusion: ESI is a safe, cost effective and minimally invasive method of treating patients of subacute or chronic LBA with radiculopathy due to herniated disc. The procedure decreases analgesic use and allows early return to work.