Other Extrahepatic Manifestations of Hepatitis C Virus Infection (Pulmonary, Idiopathic Thrombocytopenic Purpura, Nondiabetes Endocrine Disorders)

Segna, Daniel; Dufour, Jean–François

doi:10.1016/j.cld.2017.03.014

Cited by 8 publications

(7 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LIP and alveolar protreinosis were depicted only in 3.7% of patients each; the latter showed characteristic (crazy-paving pattern). Segna et al [14]. simply stated that HCV patients showed a high incidence for the development of ILD and El-Badrawy et al [13] also declared the presence of ILD and variable idiopathic interstitial pneumonias (IIPs) among those patients with high viremia.…”

Section: Ilds Were Depicted In 27% Of Group [B] Patientsmentioning

confidence: 99%

Viral hepatitis and interstitial lung diseases: can HRCT assess their relation and characterize its pattern?

Samir

ElBeheiry

Gharraf

et al. 2020

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: Clinical and pathological studies suggested the presence of a relation between active viral hepatitis and interstitial lung diseases (ILD) ranging from mild to moderate relation. Most studies attribute this relation to viral geno-physiological characteristics. The purpose of the study is first to assess the role of high-resolution computed tomography (HRCT) in evaluating the relation between viral hepatitis and ILDs, then to characterize the predominant pattern of ILD that affects patient management and prognosis. Results: This prospective study was conducted on 300 patients with viral hepatitis. They were divided into three groups of patients according to blood viremia assessed by polymerase chain reaction (PCR) as well as the diffusing capacity of carbon monoxide (DL CO) in examined pulmonary function tests (PFT). Group [A] included 100 patients with low or moderate viremia and showing normal or low to moderate DL CO decline (> 50%). Group [B] included 100 patients with high viremia and showing normal or low to moderate DL CO decline (> 50%). Group [C] included 100 patients with high viremia and showing a restrictive DL CO decline pattern (< 50%). The study included 182 males and 118 females with a ratio of 3:2, while the age ranged between 40 and 70 years (mean age of 55 years). No ILD was found among the group [A] patient. Meanwhile, 27% of patients in the group [B] showed a non-fibrotic pattern of ILD and 50% of patients in the group [C] showed a fibrotic pattern of ILD. Among patients in group [B] and group [C] together, 77 patients showed ILD accounting for 38.5%. Conclusion: In concordance with the results of the previous clinicopathological and geno-physiological studies, our HRCT results further established a mild to moderate relation between active hepatitis and ILD regardless of the pulmonary functions. The fibrotic pattern of ILD with poor response to therapy and poor prognosis was found in those patients with concomitant restrictive PFT and rapidly progressive symptoms.

show abstract

Section: Ilds Were Depicted In 27% Of Group [B] Patientsmentioning

confidence: 99%

Viral hepatitis and interstitial lung diseases: can HRCT assess their relation and characterize its pattern?

Samir

ElBeheiry

Gharraf

et al. 2020

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

show abstract

“…HCV infection is associated with several extrahepatic manifestations (EHMs), although the level of causality has not been definitely proven for all of them (Table 1; Lodi et al 2010;Negro et al 2015;Younossi et al 2016a;Balakrishnan et al 2017;Ramos-Casals et al 2017;Sayiner et al 2017;Segna and Dufour 2017;Cacoub et al 2018a). These EHMs add significantly to the HCV-related morbidity and mortality.…”

Section: Hcv-associated Extrahepatic Diseasesmentioning

confidence: 99%

Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy

Negro¹

2019

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

The hepatitis C virus (HCV) infects 71.1 million persons and causes 400,000 deaths annually worldwide. HCV mostly infects the liver, causing acute and chronic necroinflammatory damage, which may progress toward cirrhosis and hepatocellular carcinoma. In addition, HCV has been associated with several extrahepatic manifestations. The advent of safe and effective direct-acting antivirals (DAAs) has made the dream of eliminating this public health scourge feasible in the medium term. Prospective studies using DAA-based regimens have shown the benefit of HCV clearance in terms of both liver-and non-liver-related mortality.

show abstract

“…Bal et al, reported that patients having high doses of serum chronic hepatitis C RNA levels were 14.2 times more likely to show pulmonary dysfunction than non-viremic patients [ 57 ]. Segna and Dufour also reviewed the association between the hepatitis C virus (HCV) and endocrine and pulmonary manifestations [ 58 ]. Therefore, the fact that chronic hepatitis C infection can affect the lungs and other parts of the respiratory system has been well studied, but here we revealed an important finding at the cellular level, the main target cell type for chronic hepatitis C is the pulmonary neuroendocrine cell.…”

Section: Resultsmentioning

confidence: 99%

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Das

Qian

Naghavi

et al. 2022

IJMS

View full text Add to dashboard Cite

Several disease risk variants reside on non-coding regions of DNA, particularly in open chromatin regions of specific cell types. Identifying the cell types relevant to complex traits through the integration of chromatin accessibility data and genome-wide association studies (GWAS) data can help to elucidate the mechanisms of these traits. In this study, we created a collection of associations between the combinations of chromatin accessibility data (bulk and single-cell) with an array of 201 complex phenotypes. We integrated the GWAS data of these 201 phenotypes with bulk chromatin accessibility data from 137 cell types measured by DNase-I hypersensitive sequencing and found significant results (FDR adjusted p-value ≤ 0.05) for at least one cell type in 21 complex phenotypes, such as atopic dermatitis, Graves’ disease, and body mass index. With the integration of single-cell chromatin accessibility data measured by an assay for transposase-accessible chromatin with high-throughput sequencing (scATAC-seq), taken from 111 adult and 111 fetal cell types, the resolution of association was magnified, enabling the identification of further cell types. This resulted in the identification of significant correlations (FDR adjusted p-value ≤ 0.05) between 15 categories of single-cell subtypes and 59 phenotypes ranging from autoimmune diseases like Graves’ disease to cardiovascular traits like diastolic/systolic blood pressure.

show abstract

Other Extrahepatic Manifestations of Hepatitis C Virus Infection (Pulmonary, Idiopathic Thrombocytopenic Purpura, Nondiabetes Endocrine Disorders)

Cited by 8 publications

References 77 publications

Viral hepatitis and interstitial lung diseases: can HRCT assess their relation and characterize its pattern?

Viral hepatitis and interstitial lung diseases: can HRCT assess their relation and characterize its pattern?

Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes

Contact Info

Product

Resources

About