Otitis Media and Obesity—An Unusual Relationship in Children

Gavrilovici, Cristina; Spoială, Elena-Lia; Ivanov, Anca; Mocanu, Adriana; Ştreangă, Violeta; Alecsa, Mirabela-Smaranda; Miron, Ingrith

doi:10.3390/healthcare9040458

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Moreover, preventive strategies may also contribute to the reduction in antibiotic overuse in AOM. As obesity was associated with a higher risk of developing AOM [ 53 ], recent studies have investigated the role of the diet in AOM and concluded that the traditional Mediterranean diet may prevent recurrent AOM in children [ 54 ]. However, in pediatrics, the investigations are rarely conducted on large samples for ethical reasons and the validity of these results may be questionable [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum?

et al. 2023

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Acute otitis media (AOM) in children is one of the leading causes of health care visits and antibiotic prescriptions worldwide. The overall aim of the current study is twofold: 1. to analyze and discuss the antibiotic prescription patterns in AOM in children without complications or risk factors and 2. to assess to what extent the watchful-waiting approach is a real practice or a mere desideratum. We performed an electronic search in the PubMed and Embase databases from 2013 to 2023 to capture original research studies investigating antibiotic prescribing patterns for AOM in children. Among the 12 papers included in the analysis, the antibiotic prescription rate ranged from 44.8% to 98%. Our study reveals similarities regarding the use of amoxicillin as a first-line antibiotic in pediatric AOM, but also discrepancies in the watchful-waiting approach attitude and in the choice of second or third-line antimicrobial agents. The proportion of cases managed with the watchful-waiting approach ranged from 7.5% (Australia) to 55.2% (Finland). Denmark was the only country reporting penicillin V as a first-choice regimen for children with AOM, which fulfils the guidelines’ recommendations. The most unsatisfying rate of amoxicillin use was recorded in Japan, contrary to the recommendations of local guidelines. The use of quinolones was reported in two out of twelve studies, with the highest proportion in Japan, where tosufloxacin was used in 21.4% of the total number of cases. The duration of the antibiotic regimens was analyzed in three out of twelve papers. Since global antibiotic overuse contributes to the emergence of antibiotic resistant bacteria, new strategies are needed to increase the rate of watchful waiting and to promote the judicious use of antibiotics.

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Section: Discussionmentioning

confidence: 99%

Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum?

et al. 2023

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“…Furthermore, obesity is a risk factor for both type 2 diabetes and otitis media, and overweight or obese children are more susceptible to ear infections than their non-obese counterparts. [18] Although current evidence regarding the association between type 2 diabetes and otitis media is limited, additional research is necessary to fully explore potential links. Nonalcoholic fatty liver disease (NAFLD), marked by fat accumulation within the liver, has been correlated with an increased risk of diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Discovering potential pathways between type 2 diabetes mellitus and diabetic retinopathy: A big data analysis of the South Korean National Sample Cohort

2023

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Diabetes mellitus, a prevalent metabolic disorder, is associated with a multitude of complications that necessitate vigilant management post-diagnosis. A notable complication, diabetic retinopathy, could lead to intense ocular injury, including vision impairment and blindness, due to the impact of the disease. Studying the transition from diabetes to diabetic retinopathy is paramount for grasping and halting the progression of complications. In this study, we examine the statistical correlation between type 2 diabetes mellitus and retinal disorders classified elsewhere, ultimately proposing a comprehensive disease network. The National Sample Cohort of South Korea, containing approximately 1 million samples and primary diagnoses based on the International Statistical Classification of Diseases and Related Health Problems 10th Revision classification, was utilized for this retrospective analysis. The diagnoses of both conditions displayed a statistically significant correlation with a chi-square test value of P < .001, and the t test for the initial diagnosis date also yielded a P < .001 value. The devised network, comprising 27 diseases and 142 connections, was established through statistical evaluations. This network offers insight into potential pathways leading to diabetic retinopathy and intermediary diseases, encouraging medical researchers to further examine various risk factors associated with these connections.

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“…Accordingly, our study shows a trend towards higher BMI (P=0.07) among LDE. The main mechanisms for developing otitis media in obese patients include gastroesophageal reflux and/or alteration in cytokine profile [29]. The importance of circadian rhythm in the pathophysiology of diseases of the airways that are subject to systemic inflammation such as chronic obstructive pulmonary disease, chronic sinusitis, idiopathic pulmonary fibrosis or asthma, has been reported many times [30].…”

Section: Discussionmentioning

confidence: 99%

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Díez¹,

Verd²,

Ponce‐Taylor³

et al. 2022

Preprint

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Running at odds with the timing imposed by the circadian clock plays an important role in the process that leads to communicable and non communicable diseases. The primary objective of this study was to analyse whether early dinner eater children were at lower risks of acute respiratory infections than late dinner eater children, during the COVID-19 pandemic. Methods: This cross sectional study was conducted from July to December 2020 on children attending Majorcan emergency services. Clinical data collected included timing, symptoms, laboratory tests and imaging studies of current illness. Each diagnosis was validated by general paediatricians. Our survey on dinner time habits was carried out by using self-administered questionnaires. Results: A total of 669 children under age 18 were included in the study. The median of dinner time was 8:30 pm. Late dinner eaters accounted for a higher proportion of acute otitis media than early dinner eaters (7% vs 3%; P=0.028). Other infectious diseases were not associated with dinner time habits. Conclusions: We make a preliminary estimate of the link between late dinner habits and acute otitis media in children. However, no conclusions about causality can be established due to the observational design of the study.

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Otitis Media and Obesity—An Unusual Relationship in Children

Cited by 9 publications

References 39 publications

Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum?

Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum?

Discovering potential pathways between type 2 diabetes mellitus and diabetic retinopathy: A big data analysis of the South Korean National Sample Cohort

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

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