Otitis media with effusion

Atkinson, Helen; Wallis, Sebastian; Coatesworth, A P

doi:10.1080/00325481.2015.1028317

Cited by 70 publications

(47 citation statements)

References 33 publications

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“…In many cases, the only symptom of OME is fluctuating hearing status [8]. OME is often undetected until doctors raise suspicion of it or not until a child shows delayed speech development or presents with behavioural or attentional problems [8,10]. To assess hearing sensitivity in children with OME, pure tone audiometry is a key assessment tool.…”

Section: Introductionmentioning

confidence: 99%

Otitis media with effusion in children: Cross-frequency correlation in pure tone audiometry

et al. 2019

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Different guidelines are adopted in clinics and countries to assess pure tone hearing sensitivity in children with otitis media with effusion (OME). Some guidelines specify a broad range of audiometric frequencies that must be tested and from which average thresholds determined, while others leave test frequencies unspecified. For guidelines that suggest specific frequencies there are various pure tone frequencies and frequency ranges given. The present study investigated whether (1) a full range of audiometric frequencies is required to evaluate hearing loss caused by OME in children, or if neighboring frequencies provide essentially the same threshold information, and (2) if different combinations of test frequency pure tone averaging calculations may affect decision criteria for surgical treatment. In a retrospective cohort study, right and left ear air conduction pure tone threshold data were obtained, from 125 Hz to 8 kHz, for 96 children with OME aged 4 to 12 years. Paired t-tests, correlation tests (Pearson’s r, Cronbach’s alpha, intraclass correlation) and absolute differences were used to examine the relationships among pure tone audiometric (PTA) frequencies for all ears with hearing loss. 168 ears were found to have OME-related hearing loss. Only the 125 Hz—250 Hz comparison showed no statistically significant difference between neighboring thresholds. However, only the 4 kHz and 8 kHz comparison showed a clinically significant mean difference of ≥ 10 dB. When viewing individual differences, comparison between 250 Hz and 500 Hz, 125 Hz and 500 Hz, and 4 kHz and 8 kHz, showed a large number of ears with clinically significant differences between test frequencies. Comparisons among low frequency 3 PTA average (500 Hz, 1 kHz, 2 kHz), high frequency 3 PTA average (1 kHz, 2 kHz, 4 kHz), and 4 frequency PTA average (500 Hz, 1 kHz, 2 kHz, 4 kHz) showed no statistically significant differences, with very strong correlations for all comparisons. In addition, for all the combinations of PTA averages, no clinically significant differences were found for the various comparisons or among individual results. Clinically, testing hearing sensitivity in the 125 Hz to 8 kHz range is worthwhile in evaluating hearing sensitivity in children with OME due to large individual variability across audiometric frequencies. However, frequencies tested for criterion averages for surgical treatments of children with OME may be restricted to 3 frequency PTA averages, either an average of 500 Hz, 1 kHz, 2 kHz or an average of 1 kHz, 2 kHz, 4 kHz, as no clinically significant differences were found using these or a 4 frequency averaging technique. For research purposes, 250 Hz can proxy for hearing thresholds at 125 Hz; and the low frequency 3 PTA average, high frequency 3 PTA average and 4 frequency PTA average may be used interchangeably, as no statistically significant differences were found among these measures.

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Section: Introductionmentioning

confidence: 99%

Otitis media with effusion in children: Cross-frequency correlation in pure tone audiometry

et al. 2019

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“…Otitis media (OM) of the middle ear is one of the most common diseases observed in otorhinolaryngology [1], [2]. OM can be further classified as chronic OM (COM), OM with effusion (OME), and acute OM (AOM); AOM is an acute infection/inflammation of the middle ear mucosa, which also involves the mastoid hair cells [3]- [6]. Streptococcus pneumoniae (pneumococcus) is the most frequently identified bacterial organism in patients with OM.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Optical Screening of Streptococcus Pneumonia Based Inflammatory Changes of the Tympanic Membrane and Mastoid Mucosa in Guinea Pig Otitis Media Using Optical Coherence Tomography

et al. 2020

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The accurate screening of otitis media (OM) lies in clarifying the numerous confounding and quantitative factors that are discovered during primary inspections. Increased awareness about bacterial biofilms and inflammation has allowed researchers to develop a better understanding of the bacterial infections that occur in the middle ear. In this study, four live guinea pigs were inoculated with Streptococcus pneumonia to induce OM-related inflammatory changes. Since optical techniques have been effectively used for diagnosis in medicine, low-coherence interferometry-based optical coherence tomography (OCT) was employed for depth-resolved high-resolution data screening. Multiple locations of the tympanic membrane (TM), mastoid mucosa, and round window membrane were examined to assess inflammatory changes. We performed qualitative assessments and thickness quantifications and investigated the variations due to adverse inflammatory affects. The findings of the present study provide a better understanding of S. pneumonia bacteria caused inflammatory changes in middle ear and it further provides a fundamental platform for future clinical utility.

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“…Recurrent and chronic middle ear diseases are frequently encountered in otorhinolaryngological and pediatric clinical practice, and they often require specialist consultations and antibiotic prescriptions (1–3). The most frequent of these is acute otitis media (AOM), which may also be the most frequent bacterial disease affecting infants and young children (4) as almost all children have experienced at least one episode by the age of 3 years, and about one-third have experienced three or more episodes (5).…”

Section: Introductionmentioning

confidence: 99%

Phenotype Profiling and Allergy in Otitis-Prone Children

et al. 2018

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Background: Otitis-prone children can present some distinctive clinical patterns and although a number of known risk factors for recurrent acute otitis media (RAOM) are known, no dedicated epidemiological models have been developed to explain clinical heterogeneity.Methods: A preliminary retrospective pilot study was planned to evaluate the possible effect of allergic disease in the development of different disease phenotypes in otitis-prone children aged 3–10 years, particularly the absence (simple RAOM), or presence of episodes of otitis media with effusion between acute infections (RAOM with OME).Results: Analysis was based on the data contained in 153 charts (55.6% males, mean age of 59.4 ± 16.4 months). 75.8% of children had a simple RAOM and 24.2% a RAOM with OME. Atopy or allergy were documented in respectively 47.7 and 41.3% of children considered as a whole. The prevalence of atopy or allergy was significantly higher in the children with a RAOM with OME (atopy: 73.0 vs. 39.5%, p < 0.001; allergy: 60.0 vs. 36.1%, p = 0.049), who also more frequently showed adenoidal hypertrophy (p = 0.016), chronic adenoiditis (p = 0.007), conductive hearing loss (p = 0.004), and impaired tympanometry (p < 0.001).Conclusions: These data suggest that children with a RAOM with OME are clinically different from children with simple RAOM, as they have a more complex clinical presentation that includes not only adenoidal disease and audiological impairment, but also an underlying allergy or atopy. The possibility that the factors mentioned above may be differently involved in the heterogeneous clinical manifestations occurring in otitis-prone children needs to be further investigated in ad hoc epidemiological studies.

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Otitis media with effusion

Cited by 70 publications

References 33 publications

Otitis media with effusion in children: Cross-frequency correlation in pure tone audiometry

Otitis media with effusion in children: Cross-frequency correlation in pure tone audiometry

Non-Invasive Optical Screening of Streptococcus Pneumonia Based Inflammatory Changes of the Tympanic Membrane and Mastoid Mucosa in Guinea Pig Otitis Media Using Optical Coherence Tomography

Phenotype Profiling and Allergy in Otitis-Prone Children

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