Sigmoid sinus septic thrombosis is an infrequent complaint that may lead to extensive morbidity and mortality. We report a case with septic thrombosis of the sigmoid sinus caused by chronic mastoiditis and otitis media. A 29-year-old male presented with a 14-day history of tinnitus and true vertigo with a gradually developing swelling on the right side of the neck. Neck computerized tomography (CT) scan found a mastoid abscess. Also, magnetic resonance imaging (MRI) showed an enlargement of the sigmoid sinus veins that was characteristic of septic thrombophlebitis (SSST). The patient's condition and his symptoms and signs improved under antibiotic therapy and his mastoid mass size decreased gradually. In sigmoid sinus septic thrombosis, timely diagnosis and quick management, using broad-spectrum intravenous antibiotics, are critical for case recovery.