Otologic Manifestations of Immunoglobulin G4-Related Disease

Fujimoto, Shannon; Kim, Cherine H.; Green, Tedean; Xu, Helen

doi:10.1177/0145561319842852

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…Depending on the site of involvement, IgG4-RD occurring in the nasal cavity can accompany with runny nose, nasal congestion, and dull headache ( 9 ), and occurring in the throat can exhibit persistent cough, swallowing pain, and dysphonia ( 10 , 11 ). While otologic symptoms as initial manifestations may reveal tinnitus, progressive sensorineural hearing loss, serous otitis media, and even dizziness ( 12 , 13 ). Few studies, however, described nasopharyngeal symptoms as individual clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

IgG4-related disease with nasopharyngeal malignancy-like manifestations

Lin,

Fan

et al. 2024

Front. Immunol.

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BackgroundIgG4-related disease (IgG4-RD) was characterized by single or multiple masses in organs, which may mimic various inflammatory and malignant diseases. Here, we summarize 4 patients with aggressive manifestations of IgG4-RD that mimic nasopharynx cancer to provide some new sights for the diagnosis of IgG4-RD.Case summaryFour patients were included in our series. The age ranged from 53 to 64 years old, and the duration of the disease ranged from 4 to 6 months. The chief complaints included headache, rhinorrhea, or diplopia. All patients had more than 10 IgG4+ plasma cells/HPF in immunohistochemistry with plasma lgG4 levels ranging from 218 mg/dL to 765 mg/dL. All of them met the diagnostic criteria of lgG4-RD.ConclusionThe described case is highly similar to the clinical manifestations of nasopharyngeal carcinoma. Although pathology is the gold standard, there are still limitations. Serological IgG4 can help confirm the diagnosis. Timely diagnosis of IgG4-RD is of great significance in preventing secondary organ damage in patients with active diseases.

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Section: Introductionmentioning

confidence: 99%

IgG4-related disease with nasopharyngeal malignancy-like manifestations

Lin,

Fan

et al. 2024

Front. Immunol.

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Secondary autoimmune immune ear disease (AIED): a systematic review and meta-analysis on vestibular manifestations of systemic autoimmune and inflammatory disorders

et al. 2023

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IgG4-related disease presenting as otogenic skull base osteomyelitis

Yim

Ahn

et al. 2021

Auris Nasus Larynx

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IgG4-related disease (IgG4-RD) is an emerging clinical disease entity characterized by tumefactive lesions at multiple sites with a dense lymphoplasmacytic infiltrate rich in IgG4 + plasma cells.Although almost any organ can be affected, IgG4-RD is most likely to involve the submandibular, lacrimal, or parotid glands in the head and neck region. However, skull base involvement presenting as otogenic skull base osteomyelitis (SBO) is rare. We encountered a 70-year-old male with IgG4-RD presenting primarily with severe otalgia and otorrhea. He had uncontrolled diabetes mellitus and showed clinical manifestations of otogenic SBO. Tissue immunostaining revealed typical features of increased IgG4-positive plasma cells, and hematological examination showed elevated serum IgG4 concentrations. Treatment with corticosteroids significantly improved wellbeing and partially resolved the lesion based on computed tomography (CT) scan.

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Otologic Manifestations of Immunoglobulin G4-Related Disease

Cited by 6 publications

References 5 publications

IgG4-related disease with nasopharyngeal malignancy-like manifestations

IgG4-related disease with nasopharyngeal malignancy-like manifestations

Secondary autoimmune immune ear disease (AIED): a systematic review and meta-analysis on vestibular manifestations of systemic autoimmune and inflammatory disorders

IgG4-related disease presenting as otogenic skull base osteomyelitis

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