Otomastoiditis Caused by Nocardia Farcinica: A Case Report and Literature Review

Abstract

Nocardia farcinica usually infects people with impaired immune status and usually manifests in the lungs. Otomastoiditis caused by Nocardia infection is extremely rare, with only 4 cases reported to date. This report describes a case of otomastoid N. farcinica infection in an immunocompetent patient. The case was a 10-month-old immunocompetent infant who presented with an approximately 3-month history of right ear discharge for which treatment with various antibiotics had not resulted in significant improvement. Multiple cultures of secretions and pathologic examination failed to identify the causative organism. The patient then underwent right mastoidectomy. Finally, metagenomic next-generation sequencing identified the pathogen to be N. farcinica. The patient was infection-free at the 6-month follow-up but had developed labyrinthitis ossificans. Otomastoid Nocardia infection has characteristic clinical features, namely, formation of a large amount of granulation tissue and coexistence of bone destruction and new bone formation. Traditionally, Nocardia is challenging to diagnose. Metagenomic next-generation sequencing of lesions is helpful. Complete local debridement and free drainage are key to treatment.

Disseminated nocardiosis presenting as a superinfected thyroglossal duct cyst in a patient with diabetes

“…A literature review from 2023 only reported four cases of otomastoid nocardia infections. 4 As of now, nocardial sinusitis has been reported in literature in five instances, including a paediatric patient. 5 Additionally, a case report from 1990 discussed a localised nocardial disease in the upper aerodigestive tract, more specifically in a vallecular cyst.…”