Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents

Nemati, Shadman; Hassanzadeh, Ramazan; Jahromi, Sina Khajeh; Abadi, Azimeh Delkhosh Nasrollah

doi:10.1007/s00405-013-2486-0

Cited by 41 publications

(39 citation statements)

References 15 publications

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“…However, in some investigations, treatment failure (9-17%) has been reported. is failure can be due to the type of drug chosen, disregarding the possibility of resistance of the organism causing this disease, not completing the therapeutic course [27,37,38], genetic variations, surgery, or use of hearing assistive technology systems [10,11,29,30]. As an important finding of the present study, of the 161 individuals with otomycosis, only 3.1% of them had relapse after completing the therapeutic course and stated complete improvement of the disease by ENT and the patient satisfaction with their treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Otomycosis is one of the relatively common diseases in the world including Iran, claiming around 30% of ear infections [1][2][3][4][5][6][7]. Among the contributing and stimulating factors for development of otomycosis are manipulating the ears, humidity, heat, age, predisposing primary bacterial infection, and immune system disorders [8][9][10][11][12]. e main clinical findings of otomycosis include pruritus, scaling, discharge, and pain [9,13].…”

Section: Introductionmentioning

confidence: 99%

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Role of Clotrimazole in Prevention of Recurrent Otomycosis

Kiakojuri

Rajabnia

Omran

et al. 2019

BioMed Research International

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Otomycosis is one of the relatively common diseases in the world which is caused by different fungi especially saprophytes. Concerning the relapse of this disease in a number of individuals, the present study was performed to evaluate the inhibitory effect of clotrimazole drop in the relapse of otomycosis. Clinical samples were taken by an ENT specialist from patients suspicious of having otomycosis. A part of these samples were stained, and others were cultured. The diagnosis of otomycosis was made on the basis of the recognizable and characteristic appearance of fungal hyphae or mycelium and fruiting bodies and/or conidiophores under microscopic examination. Patients with suspected otomycosis are not at risk of recurrence after treatment with clotrimazole drops. Out of the 161 individuals in whom definite diagnosis of otomycosis was made, the most affected individuals were, in the age range of 40–49 years, women, urban citizens, and housewives. Pruritus and diminished hearing were the main complaints of the patients. Aspergillus niger and A. flavus as well as Candida albicans were the main causes of the disease. The relapse of disease was observed in only five patients (3.1%), where A. niger was the main fungus. Most relapses were observed in women and in those with diminished hearing, manipulating the ears, ulcers in the canal, and tympanum. Our results suggested that usage of clotrimazole can be effective in reducing the relapse of otomycosis, and concerning the high cost of treating otomycosis while the low cost of using clotrimazole, usage of this drop is recommended to reduce the relapse of otomycosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Clotrimazole in Prevention of Recurrent Otomycosis

Kiakojuri

Rajabnia

Omran

et al. 2019

BioMed Research International

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“…It is generally considered to be opportunistic occurring after treatment of bacterial infection and develops unilaterally in healthy persons and in many times a pride posing problem is present [6][7][8]. It has been found that otitis externa (OE) constitutes about 5-20% of ear consultations to otorhinolaryngologists; the majority of these cases are caused by bacteria and in 9-25% fungal agents are the cause and the microorganisms which attribute for these clinical conditions are present as saprobes in nature [9][10][11]. Otomycosis can be presented with non-specific manifestations such as itching, discomfort and otalgia, aural fullness, tinnitus decrease in hearing and otorrhea [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Presentation Pattern and Fungal Agents Spectrum Causing Otommycosis

Dekhil

2018

Asian J Pharm Clin Res

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Objective: This study was aimed to identify the pattern of presentation, influencing factors, and sort of the fungal species, distribution of sex of patients with otomycosis. Methods:Eighty-six patients attended to Ad-Diwaniyah teaching hospital, Iraq were screened for identification of fungi causing otomycosis from October 2014 to November 2015. 50 patients were females while 36 patients were males. 12 patients of the total number were with bilateral involvement. Diabetes mellitus, leukemia, chemotherapy, and chemoradiation were the associated systemic diseases which were recorded in patients with otomycosis and diabetes mellitus was detected in 53.84% of patients with systemic diseases. Results:The predominant complaints were pruritus and found in 76 patients (88.73%), discomfort and pain found in 62 patients (72.09%), aural fullness in 48 patients (55.81%), tinnitus in 34 patients (39.53%), hearing impairment in 50 cases (58.31%), ear discharge in 22 patients (25.58%), and most of the symptoms seen in 36 patients (68.14%). The results showed a total of eight fungal species belong to six different genera, namely, Aspergillus, Candida, Penicillium, Rhizopus, Alternaria, and Cephalosporium were isolated during this study. Among identified fungi, Aspergillus niger was found to be the most prevalent fungal species with 35.71% followed by Candida albicans (27.55%), Aspergillus flavus (10.20%), Aspergillus fumigatus (8.16), Penicillium digitatum (6.12%) and Cephalosporium species (4.08%), and Rhizopus species (5.1%), while Alternaria alternata had the lowest percentage (6.54%). Conclusion:Otomycosis/mycotic otitis externa is still a common problem and there is a rise in the occurrence of otomycosis in latest years, especially in tropical and subtropical humid climates.

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Section: Introductionmentioning

confidence: 99%

Presentation Pattern and Fungal Agents Spectrum Causing Otommycosis

Dekhil

2018

Asian J Pharm Clin Res

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Objective: This study was aimed to identify the public pattern of presentation, influencing factors, and sort the fungal species, distribution of sex of patients with otomycosis.Results: The predominant complaints were pruritus and found in 76 patients (88.73%), discomfort and pain found in 62 patients (72.09%), aural fullness in 48 patients (55.81%), tinnitus in 34 patients (39.53%), hearing impairment in 50 cases (58.31%), ear discharge in 22 patients (25.58%), and most of the symptoms seen in 36 patients (68.14%). The results showed a total of eight fungal species belong to six different genera, namely, Aspergillus, Candida, Penicillium, Rhizopus, Alternaria, and Cephalosporium were isolated during this study. Among identified fungi, Aspergillus niger was found to be the most prevalent fungal species with 35.71% followed by Candida albicans (27.55%), Aspergillus flavus (10.20%), Aspergillus fumigatus (8.16), Penicillium digitatum (6.12%) and Cephalosporium species (4.08%), and Rhizopus species (5.1%), while Alternaria alternata had the lowest percentage (6.54%).Conclusion: Otomycosis/mycotic otitis externa is still a common problem and there is a rise in the occurrence of otomycosis in latest years, especially in tropical and subtropical humid climates.

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Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents

Cited by 41 publications

References 15 publications

Role of Clotrimazole in Prevention of Recurrent Otomycosis

Role of Clotrimazole in Prevention of Recurrent Otomycosis

Presentation Pattern and Fungal Agents Spectrum Causing Otommycosis

Presentation Pattern and Fungal Agents Spectrum Causing Otommycosis

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