Otoneurological Findings in Inner Ear Syphilis

Kobayashi, Hideto; Mizukoshi, Kanemasa; Watanabe, Yukio; Nagasaki, Takatoshi; Ito, Muneharu; Aso, Shin

doi:10.3109/00016489109131468

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…The basic screening includes TPHA, VDRL and FTA absorption tests 15 . The symptoms in otosyphilis range from acute or fluctuating hearing loss, hearing difficulty, tinnitus, vertigo, giddiness and/or unsteadiness to spontaneous or provoked nystagmus 16–18 . Menière‐like symptoms may occur 19 but Menière's disease in its early stages is completely reversible and lasts only for hours.…”

Section: Discussionmentioning

confidence: 99%

“…In congenital syphilis malformations of the endolymphatic duct and sac, and anomalies of the semicircular canals have been observed 18 . In adult patients endolymphatic hydrops was noted 17 . Late syphilis is characterized by formation of gummata that can also cause sensorineuronal hearing loss, tinnitus and vertigo 20 …”

Section: Discussionmentioning

confidence: 99%

“…15 The symptoms in otosyphilis range from acute or fluctuating hearing loss, hearing difficulty, tinnitus, vertigo, giddiness and / or unsteadiness to spontaneous or provoked nystagmus. [16][17][18] Menière-like symptoms may occur 19 but Menière's disease in its early stages is completely reversible and lasts only for hours. In the present study, hearing loss or impairment were the most common complaints mostly associated with stage II syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…18 In adult patients endolymphatic hydrops was noted. 17 Late syphilis is characterized by formation of gummata that can also cause sensorineuronal hearing loss, tinnitus and vertigo. 20 Early treatment is mandatory for excellent outcome.…”

Section: Discussionmentioning

confidence: 99%

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Otosyphilis: report on six cases

Klemm

Wollina

2004

Acad Dermatol Venereol

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Syphilis is a multisystemic disease that may also affect the inner ear. The objective of this study was to investigate the frequency, clinical presentation and outcome of otosyphilis. A retrospective analysis of inpatients seen by a team of ENT specialists and dermatologists at a teaching hospital in Dresden, Germany, during 1986-2000. Six cases of otosyphilis had been diagnosed. None was related to risk factors such as HIV infection or drug abuse. We identified four female and two male patients, age range 25-58 years. Four patients suffered from syphilis stage II, one from syphilis stage and another from congenitial syphilis. ENT complaints included loss or impairment of hearing, tinnitus and nystagmus. All were treated with penicillin G. Adjuvant therapy included systemic corticosteroids oral pentoxifillin in two patients each. Improvement of ENT symptoms was achieved in all but one patient, who suffered from congenitial syphilis. This study confirms that otosyphilis is still a complication of syphilis in developed countries. The first line therapy is systemic penicillin G. There is a lack of controlled trials for adjuvant treatments such as corticosteroids and pentoxifillin. Clinical cooperation between dermatologists/venereologists and ENT specialists supports the best outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Otosyphilis: report on six cases

Klemm

Wollina

2004

Acad Dermatol Venereol

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“…Otologic involvement in neurosyphilis generally presents with hearing loss, but in case series it is reported that from 42 39 to 52% 40 of patients also experience vertigo. Many of these cases appear to have bilateral vestibular weakness, 40,41 with some case series reporting electronystagmographic abnormalities (typically vestibular weakness) in as high as 80% of patients. 42 Neurosyphilis has almost disappeared due to increased use of antibiotics.…”

Section: Neurosyphilismentioning

confidence: 99%

Bilateral Vestibular Loss

2013

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Bilateral vestibular loss is a rare cause of visual disturbance (oscillopsia) and imbalance. When severe, the most common cause is iatrogenic-gentamicin ototoxicity. Bilateral loss is easily diagnosed at the bedside with the dynamic illegible E test. If this test is omitted, it can easily be misdiagnosed as a cerebellar syndrome. Treatment is largely supportive. Care should be taken to avoid medications that suppress vestibular function, and to encourage activity.

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Miscellaneous vestibular nerve and labyrinthine disorders

Brandt¹

1999

Vertigo

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Otoneurological Findings in Inner Ear Syphilis

Cited by 9 publications

References 10 publications

Otosyphilis: report on six cases

Otosyphilis: report on six cases

Bilateral Vestibular Loss

Miscellaneous vestibular nerve and labyrinthine disorders

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