Otopathology in Congenital Toxoplasmosis

Şalvız, Mehti; Montoya, José G.; Nadol, Joseph B.; Santos, Felipe

doi:10.1097/mao.0b013e31828297b6

Cited by 38 publications

(25 citation statements)

References 11 publications

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“…Infection with T. gondii has been associated with hearing loss in congenital toxoplasmosis. This hearing loss is likely caused by inflammation induced by tachyzoites of T. gondii [ 29 ]. Congenital hearing loss has not always been associated with primary infection during pregnancy [ 30 ], and very little is known about hearing loss caused by T. gondii in adults.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii infection in interstate truck drivers: a case–control seroprevalence study

Alvarado‐Esquivel¹,

Pacheco-Vega²,

Hernández‐Tinoco³

et al. 2015

Parasites & Vectors

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BackgroundInfection with Toxoplasma gondii can be acquired via the ingestion of undercooked or raw meat containing tissue cysts, or via ingestion of water contaminated with oocysts. Professional long distance truck driving may have epidemiological importance for food-borne infections since drivers eat out of home and in places where hygiene and cooking practices are uncertain. We aimed to determine whether interstate truck drivers in Durango, Mexico have an increased risk of infection with T. gondii as indicated by seropositivity; and to determine the socio-demographic, work, clinical, and behavioral characteristics associated with T. gondii seropositivity in interstate truck drivers.MethodsThrough a case–control study design, 192 truck drivers and 192 controls from the general population of the same region matched by gender and age were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies. Socio-demographic, work, clinical and behavioral characteristics from the truck drivers were obtained.ResultsAnti-T. gondii IgG antibodies were found in 23 (12.0%) of 192 truck drivers and in 13 (6.8%) of 192 controls (OR = 21.0; 95% CI: 1.23-358.38; P = 0.002). Anti-T. gondii IgM antibodies were found in 7 (3.6%) cases and in 7 (3.6%) controls (P = 1.00). The seroprevalence of T. gondii infection was higher in drivers with reflex impairment than in those without this impairment (4/13, 30.8% vs 19/179, 10.6%, respectively; P = 0.05), and in drivers with hearing impairment than in those without this impairment (3/7, 42.9% vs 20/185, 10.8%, respectively; P = 0.03). Multivariate analysis of work and behavioral characteristics of truck drives showed positive associations of T. gondii exposure with trips to the south of Mexico (OR = 3.11; 95% CI: 1.02-9.44; P = 0.04) and consumption of horse meat (OR = 5.18; 95% CI: 1.62-16.55; P = 0.005).ConclusionsResults suggest that interstate truck drivers may have an increased risk for T. gondii infection, and that T. gondii exposure may be impacting neurological functions in truck drivers. Contributing factors for T. gondii exposure should be taken into account for the design of optimal prevention measures against T. gondii infection.

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Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii infection in interstate truck drivers: a case–control seroprevalence study

Alvarado‐Esquivel¹,

Pacheco-Vega²,

Hernández‐Tinoco³

et al. 2015

Parasites & Vectors

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“…Such an immunological reaction would damage the vestibulocochlear nerve, which is found in the internal acoustic meatus, and would justify the greater occurrence of retrocochlear alterations in the SG 24 .…”

Section: Discussionmentioning

confidence: 99%

Alterações auditivas em crianças expostas à toxoplasmose durante a gestação

et al. 2017

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RESUMO Objetivo: verificar a ocorrência e o tipo mais frequente de alteração auditiva em crianças expostas a toxoplasmose durante a gestação. Métodos: estudo retrospectivo longitudinal realizado em instituição pública de saúde de São Paulo. Análise de prontuários de crianças nascidas entre 2010 e 2015 distribuídos em dois grupos: grupo estudo, composto por 48 crianças de mães com diagnóstico de toxoplasmose durante a gestação; e grupo controle, composto por 43 crianças sem infecção congênita que foram acompanhadas por apresentar baixo peso ao nascimento. As crianças foram avaliadas de duas a quatro vezes durante os dois primeiros anos de vida, por meio de testes que avaliam a função auditiva periférica e central. Resultados: 47 crianças fizeram apenas duas avaliações e apenas 11 completaram todas as avaliações até 24 meses. No grupo controle 58,1% apresentaram audição normal, 37,2% perda condutiva, 4,7% perda coclear e ausência de alteração retrococlear, enquanto o grupo estudo apresentou 56,3% de audição normal, 20,8% de perda condutiva, 2,1% de perda coclear e 20,8% de alteração retrococlear. Conclusão: crianças expostas à toxoplasmose durante a gestação não diferiram das não expostas em relação à ocorrência de perda auditiva coclear e condutiva. Entretanto, apresentaram maior ocorrência de alteração retrococlear.

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“…The association of infection and hearing impairment in applicants of medical certificates found in the present study may also be critical for occupational health since this impairment may hamper the performance in work and study. Both retinochoroiditis and otopathology have been found in newborns with congenital toxoplasmosis [ 27 ]. However, ear disease due to T. gondii infection in adults has been poorly studied.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of Toxoplasma Gondii Infection in People Applying for Medical Certificates

Alvarado‐Esquivel

Sánchez‐Anguiano

Hernández‐Tinoco

et al. 2016

EuJMI

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Medical certificates are documents that state the health status of a person. This study aimed to determine the seroprevalence and risk factors for Toxoplasma gondii infection in applicants of medical certificates and to investigate seroprevalence association with characteristics of these individuals. We examined 404 applicants in a public health center in Durango City, Mexico for the presence of anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays. Of the 404 subjects (mean age of 35.94 ± 13.01) studied, 29 (7.2%) were positive for anti-T. gondii IgG antibodies and 9 (31.0%) of them were also positive for anti-T. gondii IgM antibodies. IgG and IgM seropositivities were associated with vision impairment (P = 0.04) and a history of surgery (P = 0.03), respectively. Prevalence of high (>150 IU/ml) IgG antibody levels was associated with hearing impairment (P = 0.03), and histories of lymphadenopathy (P = 0.04) and miscarriages (P = 0.03). Multivariate analysis showed that T. gondii seropositivity was associated with being born out of Durango State (odds ratio [OR] = 4.65; 95% confidence interval [CI]: 1.25–17. 29; P = 0.02) and soil contact (OR = 4.27; 95% CI: 1.71–10.67; P = 0.002) and negatively associated with consumption of sheep meat (OR = 0.12; 95% CI: 0.02–0.65; P = 0.01). These results could be used for the design of optimal preventive measures against toxoplasmosis and its sequelae.

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Otopathology in Congenital Toxoplasmosis

Cited by 38 publications

References 11 publications

Toxoplasma gondii infection in interstate truck drivers: a case–control seroprevalence study

Toxoplasma gondii infection in interstate truck drivers: a case–control seroprevalence study

Alterações auditivas em crianças expostas à toxoplasmose durante a gestação

Seroepidemiology of Toxoplasma Gondii Infection in People Applying for Medical Certificates

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