Otospondylomegaepiphyseal Dysplasia

Williams, Benjamin R.; Calhoun, Amy; Holton, Kenneth J.; Kelly, Brandon J.; Sembrano, Jonathan N.

doi:10.2106/jbjs.cc.20.00140

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Early-stage surgical repair of skeletal abnormalities in children with type 3 SS has been reported in the past, and the short-term outcome is favorable. However, as age increases and the disease symptoms worsen, the surgical intervention becomes more challenging ( Williams et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2

Ran

Liu

et al. 2023

Front. Genet.

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Background: Stickler syndrome (SS) is a group of hereditary collagenopathies caused by a variety of collagen and non-collagen genes. Affected patients have characteristic manifestations involving ophthalmic, articular, craniofacial and auditory disorders. SS is classified into several subtypes according to clinical and molecular features. Type 3 SS is an ultra-rare disease, known as non-ocular SS or otospondylomegaepiphyseal dysplasia (OSMED) with only a few pathogenic COL11A2 variants reported to date.Case presentation: A 29-year-old Chinese male was referred to our hospital for hearing loss and multiple joint pain. He presented a phenotype highly suggestive of OSMED, including progressive sensorineural deafness, spondyloepiphyseal dysplasia with large epiphyses, platyspondyly, degenerative osteoarthritis, and sunken nasal bridge. We detected compound heterozygous mutations in COL11A2, both of which were predicted to be splicing mutations. One is synonymous mutation c.3774C>T (p.Gly1258Gly) supposed to be a splice site mutation, the other is a novel intron mutation c.4750 + 5 G>A, which is a highly conservative site across several species. We also present a review of the current known pathogenic mutation spectrum of COL11A2 in patients with type 3 SS.Conclusion: Both synonymous extonic and intronic variants are easily overlooked by whole-exome sequencing. For patients with clinical manifestations suspected of SS syndrome, next-generation whole-genome sequencing is necessary for precision diagnosis and genetic counseling.

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Section: Discussionmentioning

confidence: 99%

Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2

Ran

Liu

et al. 2023

Front. Genet.

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Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2: a case report

Ran

Liu

et al. 2022

Preprint

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Background Stickler syndrome (SS) is a group of hereditary collagenopathies caused by a variety of collagen and non-collagen genes. Affected patients have characteristic manifestations involving ophthalmic, articular, craniofacial and auditory disorders. SS is classified into several subtypes according to clinical and molecular features. Type 3 SS is ultra-rare, known as non-ocular SS or otospondylomegaepiphyseal dysplasia (OSMED) with only a few ballistic COL11A2 variants reported to date. Case presentation A 29-year-old Chinese male was referred to our hospital for hearing loss and multiple joint pain. He presented a phenotype highly suggestive of OSMED, including progressive sensorineural deafness, spondyloepiphyseal dysplasia with large epiphyses, platyspondyly, degenerative osteoarthritis, and sunken nasal bridge. We detected compound heterozygous mutations in COL11A2, both of which are predicted to be splicing mutations. One of the mutations is synonymous mutation c.3774C > T (p.Gly1258Gly) whereas it may cause splicing mutation predicted by in silico analysis, the other is a novel intron mutation c.4750 + 5 G > A which is a highly conservative site across several species. The patient received medications to alleviate the joint pain and osteoporosis. We also present a review of the current known pathogenic mutation spectrum of COL11A2 in patients with type 3 SS. Conclusion For patients with characteristic manifestations of SS syndrome, next-generation genetic analysis is beneficial for precision medical care and genetic counseling.

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Otospondylomegaepiphyseal Dysplasia

Cited by 2 publications

References 14 publications

Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2

Case report: Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2

Autosomal recessive type 3 Stickler syndrome caused by compound heterozygous mutations in COL11A2: a case report

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