Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection

Tange, R. A.; Dreschler, Wouter A.; Claessen, F. A. P.; Perenboom, R. M.

doi:10.1016/s0385-8146(96)00031-4

Cited by 39 publications

(18 citation statements)

References 7 publications

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“…Quinine induced ototoxicity is characterized by reversible hearing loss mainly at ultrahigh frequencies and mainly in patients with Plasmodium falciparum malaria as compared to healthy individuals [8]. Our patient did not suffer from malaria and has hearing loss at low frequencies.…”

Section: Discussionmentioning

confidence: 57%

Bilateral superior semicircular canal dehiscence in a child with sensorineural hearing loss and without vestibular symptoms

Kanaan

Raad

Hourani

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 57%

Bilateral superior semicircular canal dehiscence in a child with sensorineural hearing loss and without vestibular symptoms

Kanaan

Raad

Hourani

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…This was indeed the case in a study where quinine was given to 12 healthy and 10 faciparum-infected subjects. 26 None of the healthy group reported a hearing loss or associated tinnitus/dizziness. On audiometric assessment, hearing loss (,25 dB) was noted, especially in the high frequencies in nine of the 12 volunteers (2-4 h after infusion).…”

Section: Pre-treatment Assessment Of Hearing Lossmentioning

confidence: 90%

Deafness: malaria as a forgotten cause

Zhao

Mackenzie

2011

Annals of Tropical Paediatrics

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Evidence from this review suggests that the falciparum parasite is a potential cause of hearing loss. Malaria is a disease of such high prevalence that even if only a small proportion of survivors develop this impairment the effects on children's education could be detrimental. More attention should be focussed on investigating this association as the clinical and pathophysiological implications are potentially considerable.

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“…Comúnmente, se le atribuye a la quinina y sus derivados efectos ototóxicos que producen hipoacusia neurosensorial acompañada de síntomas como zumbidos, vértigo, náuseas y vómito, y alteraciones de la visión. La quinina y sus derivados causan ototoxicidad cualquiera que sea la vía de administración, debido a una degeneración de las células ciliadas del órgano de Corti (44,45). En un estudio dirigido a evaluar los efectos ototóxicos del tratamiento antipalúdico en 725 pacientes, en Mozambique, se encontró que 78% de los pacientes tratados con antipalúdicos desarrolló hipoacusia neurosensorial, y la quinina y la cloroquina fueron los dos fármacos con mayor capacidad de lesionar el vestíbulo (46).…”

Section: Discussionunclassified

Estudio piloto de la eficacia y de los efectos sobre los gametocitos del esquema artesunato-mefloquina-primaquina para la malaria por Plasmodium falciparum

et al. 2009

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Introducción. El tratamiento de la malaria por P. falciparum requiere de un esquema seguro, eficaz y de impacto en la transmisión. En 2006, se implementó en Antioquia el esquema artesunato-mefloquina y se adicionó primaquina para eliminar los gametocitos. Objetivo. Evaluar la eficacia y acción gametocida de los esquemas artesunato-mefloquinaprimaquina y artesunato-mefloquina en pacientes con malaria no complicada por P. falciparum de Turbo, Antioquia. Materiales y métodos. Ensayo clínico aleatorio; los tratamientos se suministraron de forma supervisada y se realizó seguimiento clínico-parasitológico en los días 1, 2, 3, 7, 14, 21, 28, 35, y 42, para evaluar la respuesta según el protocolo OMS-2003 modificado. Resultados. Entre abril de 2007 y febrero de 2008, 50 pacientes fueron reclutados; los resultados mostraron una eficacia de 100% (IC95% 86,3%-100%) para el esquema artesunato-mefloquina (con/sin primaquina); la parasitemia y la fiebre fueron eliminadas completamente al tercer día de tratamiento en todos los pacientes. La eliminación de gametocitos fue mayor con el uso de primaquina; al tercer día de seguimiento, el 92% (IC95% 74%-99%) de los pacientes que recibieron primaquina no tuvieron gametocitos, en comparación con 78,3% (IC95% 59%-93%) de pacientes del grupo artesunato-mefloquina. Además, el esquema artesunato-mefloquinaprimaquina eliminó la gametocitemia una semana antes que el esquema sin primaquina. Conclusión. Se recomienda el uso del esquema artesunato-mefloquina para la malaria por P. falciparum por su alta eficacia y se sugieren futuras evaluaciones del beneficio de la PQ en la reducción de la densidad y prevalencia de gametocitos.Palabras clave: Plasmodium falciparum, malaria, artesunato, mefloquina, primaquina, resultado del tratamiento. Therapeutic efficacy of a regimen of artesunate-mefloquine-primaquine treatment for Plasmodium falciparum malaria and treatment effects on gametocytic developmentIntroduction. The treatment of Plasmodium falciparum malaria requires a safe and effective therapeutic treatment regimen, which in turn has high impact on the transmission. In 2006, an artesunate (AS)-mefloquine (MQ) treatment program was implemented in Antioquia. In addition, primaquine (PQ) was added to eliminate malaria gametocytes in the bloodstream. Objective. The efficacy and gametocytocidal activity was evaluated for two treatment regimens, AS-MQ-PQ and AS-MQ, in patients with uncomplicated P. falciparum malaria. Materials and methods. Between April 2007 and February 2008, 50 patients were recruited for the trial in Turbo, Antioquia. A randomized clinical trial was conducted. Treatment compliance was supervised, with a clinical and parasitological assessment on days 1,2,3,7,14,21,28,35, and 42 to evaluate response rate according to the WHO 2003 protocol. Results. Clinical response and parasite elimination efficacy of AS-MQ (with or without PQ) was 100% (95% CI 86.3%-100%), and parasitemia and fever were absent on day 3 of treatment in all patients. Gametocyte elimination was superior when PQ w...

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Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection

Cited by 39 publications

References 7 publications

Bilateral superior semicircular canal dehiscence in a child with sensorineural hearing loss and without vestibular symptoms

Bilateral superior semicircular canal dehiscence in a child with sensorineural hearing loss and without vestibular symptoms

Deafness: malaria as a forgotten cause

Estudio piloto de la eficacia y de los efectos sobre los gametocitos del esquema artesunato-mefloquina-primaquina para la malaria por Plasmodium falciparum

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