Ototoxicity Induced by Furosemide

Schwartz, Gabriel H.; David, David S.; Riggio, Robert R.; Stenzel, Kurt H.; Rubin, Albert L.

doi:10.1056/nejm197006182822506

Cited by 108 publications

(19 citation statements)

References 13 publications

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“…Reversible changes in EP also have been demonstrated in the chinchilla, where a dose-related fall in EP was observed following injection of furosemide, and the levels of EP recovered after less than two hours4041. Recovery of EP was noted even after furosemide was given at 100 times the typical human therapeutic dose42. In line with this experimental animal data, transient hearing loss was also found in humans after high dose furosemide treatment43.…”

Section: Discussionsupporting

confidence: 68%

Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium

Lee

Hackelberg

Green

et al. 2017

Sci Rep

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Hair cells in the mature cochlea cannot spontaneously regenerate. One potential approach for restoring hair cells is stem cell therapy. However, when cells are transplanted into scala media (SM) of the cochlea, they promptly die due to the high potassium concentration. We previously described a method for conditioning the SM to make it more hospitable to implanted cells and showed that HeLa cells could survive for up to a week using this method. Here, we evaluated the survival of human embryonic stem cells (hESC) constitutively expressing GFP (H9 Cre-LoxP) in deaf guinea pig cochleae that were pre-conditioned to reduce potassium levels. GFP-positive cells could be detected in the cochlea for at least 7 days after the injection. The cells appeared spherical or irregularly shaped, and some were aggregated. Flushing SM with sodium caprate prior to transplantation resulted in a lower proportion of stem cells expressing the pluripotency marker Oct3/4 and increased cell survival. The data demonstrate that conditioning procedures aimed at transiently reducing the concentration of potassium in the SM facilitate survival of hESCs for at least one week. During this time window, additional procedures can be applied to initiate the differentiation of the implanted hESCs into new hair cells.

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Section: Discussionsupporting

confidence: 68%

Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium

Lee

Hackelberg

Green

et al. 2017

Sci Rep

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“…Schwartz et al [113] reported transitory hearing loss in five adult patients who received high doses of furosemide intravenously. Heidland and Wigand [14] found that among patients with severe renal failure, infusion of furosemide at a constant rate of 25 mg/min caused noticeable hearing loss in two thirds of their patients.…”

Section: Resultsmentioning

confidence: 99%

Clinical Pharmacology of Furosemide in Neonates: A Review

Pacifici

2013

Pharmaceuticals

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Furosemide is the diuretic most used in newborn infants. It blocks the Na+-K+-2Cl− symporter in the thick ascending limb of the loop of Henle increasing urinary excretion of Na+ and Cl−. This article aimed to review the published data on the clinical pharmacology of furosemide in neonates to provide a critical, comprehensive, authoritative and, updated survey on the metabolism, pharmacokinetics, pharmacodynamics and side-effects of furosemide in neonates. The bibliographic search was performed using PubMed and EMBASE databases as search engines; January 2013 was the cutoff point. Furosemide half-life (t1/2) is 6 to 20-fold longer, clearance (Cl) is 1.2 to 14-fold smaller and volume of distribution (Vd) is 1.3 to 6-fold larger than the adult values. t1/2 shortens and Cl increases as the neonatal maturation proceeds. Continuous intravenous infusion of furosemide yields more controlled diuresis than the intermittent intravenous infusion. Furosemide may be administered by inhalation to infants with chronic lung disease to improve pulmonary mechanics. Furosemide stimulates prostaglandin E2 synthesis, a potent dilator of the patent ductus arteriosus, and the administration of furosemide to any preterm infants should be carefully weighed against the risk of precipitation of a symptomatic patent ductus arteriosus. Infants with low birthweight treated with chronic furosemide are at risk for the development of intra-renal calcifications.

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“…The remaining ten non-shunted cirrhotics were selected for study from the liver clinic of this hospital. One patient in the shunted and one in the non-shunted group had received potentially ototoxic diuretics -furosemide [5] and/or ethacrynic acid [4] and were therefore excluded.…”

Section: Methodsmentioning

confidence: 99%

Sensori-Neural Hearing Loss in Alcoholic Cirrhosis

Koff¹,

Oliai²,

Sparks³

1973

Digestion

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Pure-tone audiological examination was performed in 22 neomycin-treated and untreated stable alcoholic cirrhotic patients, 10 of whom had previously undergone porta-caval shunt surgery. Severe sensori-neural hearing losses were found in the shunted group only, regardless of whether or not they had previously received neomycin. Normal audiograms were seen only among non-shunted cirrhotics. Air conduction hearing thresholds for frequencies above 3 kHz were significantly higher (poorer hearing) in the shunted compared to the non-shunted group. Thresholds were also significantly higher in shunted patients who had not received neomycin when compared to non-shunted neomycin untreated cirrhotics. These data indicate that factors other than neomycin may be contributing to the hearing loss encountered in alcoholic cirrhotics.

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Ototoxicity Induced by Furosemide

Cited by 108 publications

References 13 publications

Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium

Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium

Clinical Pharmacology of Furosemide in Neonates: A Review

Sensori-Neural Hearing Loss in Alcoholic Cirrhosis

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