Otteliones A and B:  Potently Cytotoxic 4-Methylene-2-cyclohexenones from Ottelia alismoides

Synthesis of the Otteliones A and B: Use of a Cyclopropyl Group as Both a Steric Shield and a Vinyl Equivalent

“…[1] For example, total growth inhibition was observed against one breast cancer cell line and one CNS cancer cell line in the nm to pm range. [1] Additionally, it has been established that ottelione A inhibits tubulin polymerization.…”

Recent Developments on Domino Metathesis Reactions in India

“…4). [20,21] Otteliones, isolated from the freshwater plant Ottelia alismoides, [20] display antitubercular activity and cytotoxicity at sub-nanomolar levels against a panel of 60 human cancer cell lines. Loloanolides [21] have been isolated from the extract of aerial parts of Camchaya loloana, and exhibit cytotoxicity against the HepG2 cell line, with GI50 values at a nanomolar level.…”

An Eventful Synthetic Approach Towards the Biologically Potent Natural Product Ottelione A: Enantio-, Regio- and Stereoselective Construction of the Bicyclic Core

“…1 Extensive and incisive NMR studies led to the formulation of ottelione B as 1 but definitive stereostructure to ottelione A could not be arrived at and both 2a and 2b were considered as the likely structures for this natural product. 1 Otteliones exhibit quite remarkable biological activity profiles.…”

“…1 Extensive and incisive NMR studies led to the formulation of ottelione B as 1 but definitive stereostructure to ottelione A could not be arrived at and both 2a and 2b were considered as the likely structures for this natural product. 1 Otteliones exhibit quite remarkable biological activity profiles. 2,3 During in vitro screening against a panel of 60 human cancer cell lines at the National Cancer Institute (NCI), both 1 and 2 have been shown to exhibit cytotoxicity at nM-pM concentration.…”