Our approach to follicular-patterned lesions of the thyroid

Baloch, Zubair W.; LiVolsi, Virginia A.

doi:10.1136/jcp.2006.038604

Cited by 121 publications

(75 citation statements)

References 80 publications

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“…Follicular thyroid carcinoma (FTC), the second most common differentiated thyroid cancer, shows more aggressive clinicopathological features and a greater rate of recurrence than papillary thyroid carcinomas (PTCs). Additionally, FTCs are more prone to metastasize to the lung, bone, brain, and liver in comparison with PTCs (Baloch & LiVolsi 2007, Witt 2008. Moreover, FTC can only be diagnosed if capsule and vascular invasion are found in the surgical resection specimens, making it difficult to diagnose by fine needle aspiration (FNA) biopsy (Baloch & LiVolsi 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, FTCs are more prone to metastasize to the lung, bone, brain, and liver in comparison with PTCs (Baloch & LiVolsi 2007, Witt 2008. Moreover, FTC can only be diagnosed if capsule and vascular invasion are found in the surgical resection specimens, making it difficult to diagnose by fine needle aspiration (FNA) biopsy (Baloch & LiVolsi 2007). Understanding the genetic alterations in FTCs and their mechanisms is fundamentally important in developing new molecular markers for earlier diagnosis and novel therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

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Proteomic analysis of differentially expressed proteins in normal human thyroid cells transfected with PPFP

Li¹,

Wang²,

Liu³

et al. 2012

Endocrine-Related Cancer

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The fusion gene encoding the thyroid-specific transcription factor PAX8 and peroxisome proliferator-activated receptor g (PPARg (PPARG)) (designated as the PPFP gene) is oncogenic and implicated in the development of follicular thyroid carcinoma (FTC). The effects of PPFP transfection on the biological characteristics of Nthy-ori 3-1 cells were studied by MTT assay, colony formation, soft-agar colony formation, and scratch wound-healing assays as well as by flow cytometry. Furthermore, the differentially expressed proteins were analyzed on 2-DE maps and identified by MALDI-TOF-MS. Validation of five identified proteins (prohibitin, galectin-1, cytokeratin 8 (CK8), CK19, and HSP27) was determined by western blot analysis. PPFP not only significantly increased the viability, proliferation, and mobility of the Nthy-ori 3-1 cells but also markedly inhibited cellular apoptosis. Twenty-eight differentially expressed proteins were identified, among which 19 proteins were upregulated and nine proteins were downregulated in Nthy-ori 3-1 PPFP (Nthy-ori 3-1 cells transfected with PPFP). The western blot results, which were consistent with the proteome analysis results, showed that prohibitin was downregulated, whereas galectin-1, CK8, CK19, and HSP27 were upregulated in Nthy-ori 3-1 PPFP . Our results suggest that PPFP plays an important role in malignant thyroid transformation. Proteomic analysis of the differentially expressed proteins in PPFP-transfected cells provides important information for further study of the carcinogenic mechanism of PPFP in FTCs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of differentially expressed proteins in normal human thyroid cells transfected with PPFP

Li¹,

Wang²,

Liu³

et al. 2012

Endocrine-Related Cancer

View full text Add to dashboard Cite

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“…None of them showed conclusive results [22,23]. It has to be mentioned that DNA microarray gene analysis on thyroid tumors successfully discriminated benign and malignant tumors including borderline lesions [24]. Continuous progress in molecular studies on thyroid tumors hopefully will determine the emergence of a useful diagnostic tool in the future.…”

Section: Case Examplementioning

confidence: 99%

Endocrine Dysfunction in Neurofibromatosis Type 1 – An Update

Pop

Neagoe

Kolcsár

et al. 2016

Acta Medica Marisiensis

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Background: Neurofibromatosis type 1 is an autosomal dominant disorder associated with multiple neoplasms particularly those of ectodermal origin. Various endocrine pathologies are often present, among them, hyperparathyroidism and follicular thyroid lesion are very rare described and their coincidence in the same patient has not been described in the literature reviewed. Subject: A 59-years-old woman with clinical manifestation of neurofibromatosis type 1 developed dysphagia, dysphonia, choking sensation. Physical and imagistic examination revealed a multinodular goiter with microfollicular lesion on fine needle aspiration biopsy (FNAB), elevated parathormone levels and severe osteoporosis. The surgically removed thyroid contained a nodule with follicular architecture of uncertain malignant potential; the parathyroid tissue appeared normal. Discussion and conclusion: This case serves as a reminder to look for non-neurogenic tumors in patients with neurofibromatosis. Clinicians must be aware of the diverse clinical features of this genetic disorder.

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“…3,7 Follicular carcinomas represent approximately 5% of all thyroid malignancies in the United States.…”

Section: This Article Is Part Of the Five Top Stories In Anatomicmentioning

confidence: 99%

“…3,4 The differential diagnoses of a lesion with this pattern include, but are not limited to, FC, follicular adenoma (FA), goiter or hyperplasic nodule, follicular variant of papillary thyroid carcinoma (FVPTC), and Hürthle cell tumor. 3,[5][6][7] The distinction between these entities, based on the morphologic and immunohistochemical (IHC) characteristics, is not always easy and even more disappointingly, there is no general consensus about the criteria based on which a pathologist could make the appropriate diagnosis. 4 No wonder some have referred to these lesions as ''bane of the pathologist.…”

Section: This Article Is Part Of the Five Top Stories In Anatomicmentioning

confidence: 99%

Five Top Stories in Thyroid Pathology

Moghaddam

Virk

Sakhdari

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Thyroid carcinoma is the most common malignant tumor of endocrine organs, yet it only accounts for approximately 1% of all cancers in the United States with more than 35 000 new cases diagnosed each year and more than 450 000 people living with this disease. While most tumors can be diagnosed without much difficulty, a few tumor types, especially tumors with follicular pattern, sometimes pose a diagnostic challenge.Objective.-To discuss morphologic, immunohistochemical, and molecular features of thyroid tumors. We also explore the clinicopathologic features of papillary microcarcinoma and medullary microcarcinoma and how the latter is related and differentiated from C-cell hyperplasia.Finally with the ever-growing list of organ systems involved in immunoglobulin (Ig) G4-related diseases, we discuss the still not completely explored IgG-4-related thyroid disease.Data Sources.-Data were obtained from review of the pertinent peer-reviewed literature and institutional experience.Conclusions.-Histomorphologic evaluation still remains the gold standard for diagnosis in most cases of thyroid diseases. The application of ancillary studies such as immunohistochemistry and molecular diagnosis, including next-generation sequencing, is becoming more common.

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Our approach to follicular-patterned lesions of the thyroid

Cited by 121 publications

References 80 publications

Proteomic analysis of differentially expressed proteins in normal human thyroid cells transfected with PPFP

Proteomic analysis of differentially expressed proteins in normal human thyroid cells transfected with PPFP

Endocrine Dysfunction in Neurofibromatosis Type 1 – An Update

Five Top Stories in Thyroid Pathology

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