Our phytochemical research on Jatropha species

Immigrants from the Dominican Republic (DR) and Haiti are among the top foreign-born communities in New York City (NYC). As people migrate to new countries, they bring their ethnomedical beliefs and practices, and adapt their plant pharmacopoeias. Haiti and the DR share a flora on the island of Hispaniola. In NYC, the flora is limited to what is available in the city. We selected plants for future laboratory research based on ethnobotanical data from two surveys among Dominicans in the DR and NYC, and a Haitian literature review. In both Dominican datasets, gynecological infections were the top women's health condition treated with plants. We identified 10 species for this purpose reported by Dominicans that are also known medicines in Haitian culture, although not yet documented for women's health. Plants for gynecological infections potentially cause dysbiosis of the vaginal microbiota, and may increase rather than prevent disease. There is a public health need to assess traditional medicines for their ability to inhibit pathogenic bacteria, while causing minimal disruption to the vaginal flora. Several species are known antibacterials, but remain to be tested for their efficacy. These results also provide a foundation for a planned ethnobotanical survey among NYC Haitian women.

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Naturally Occurring O-Heterocycles as Anticancer Agents

Avula

Das

Csük

et al. 2022

ACAMC

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: Cancer is a leading cause of death worldwide. Proper efficient drugs are required to treat this deadly disease. Natural products have long been a vital source of anticancer agents and they have generated various “lead compounds” suitable for drug developments. With the recent advancement of chemical synthesis and bioevaluation techniques these lead compounds of natural origins have been utilized for production of useful anticancer drugs. Among the naturally occurring bioactive compounds various O-heterocycles have been evaluated as remarkable cancer therapeutic agents. These compounds generally possess unique structures and novel mechanism of action. In the present review article, some selected O-heterocycles as promoting anticancer agents have been discussed in brief. Various natural sources and chemistry as well as bioactivities of these compounds have been described. The development of improved analogues of these compounds through synthetic modifications and efficient bioevaluation along with proper studies on structure-activity relationship and mechanism of actions has been mentioned. The article has demonstrated the recent relevance of naturally occurring O-heterocyclic compounds in current anticancer drug discovery and development scenario.

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Our phytochemical research on Jatropha species

Cited by 5 publications

References 27 publications

Medicinal and Aromatic Plant Species with Potential for Remediation of Metal(loid)-Contaminated Soils

Medicinal and Aromatic Plant Species with Potential for Remediation of Metal(loid)-Contaminated Soils

Caribbean Women’s Health and Transnational Ethnobotany

Naturally Occurring O-Heterocycles as Anticancer Agents

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