Out Come of Topical Phenytoin in the Management of Diabetic Ulcers

Kodela, Sankar Rao; Kumar, Tushar; Vivek, .

doi:10.9790/0853-1507123954

Cited by 4 publications

(5 citation statements)

References 63 publications

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“…Our study found that overall most common organism in diabetic ulcer was staph aureus with 47.5% of the total in both groups. Similar results were seen by the studies conducted by Kodela SR [17] et al, they also found that most common microorganism was staph aureus with 45% of the total and Jayalal et al found that staph aureus was the most common organism in 48.33% of the total. The efficacy of the dressing or quality of graft bed was assessed as the percentage of ulcer surface area covered by granulation tissue at 9 th day.…”

Section: Discussionsupporting

confidence: 78%

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

Sandhu¹,

Singh²,

Banga³

et al. 2018

Int. J. Orthop. Sci.

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Introduction:The stimulatory effect of phenytoin on connective tissue suggested possibility for its use in wound healing. Oral phenytoin was first introduced as an antiseizure medication in 1937. Over 60 years investigators have shown an interest in how topical phenytoin may be used to promote wound healing in a variety of chronic wounds. Materials and Methods: A sample of 40 patients with diabetic ulcers was selected using purposive sampling technique. The patients were divided into two groups: Group A (Phenytoin group) (n=20) and Group B (conventional group) (n=20). In Group A, the patient's dressing were done using phenytoin and in Group B, with povidine. The patients were followed up on a daily basis for 9 days in both study and control groups. Wound culture was obtained at the start of the treatment and on the 7 th day of treatment. Then the patients were subjected to split thickness skin grafting on 10 th day. The follow up of the patients were done at one month after discharge in outpatient department for post skin grafting complications. Result: The mean duration of hospital stay in phenytoin group was 21.35±4.71 (SD) days and that in the conventional group was 27.3±6.48 (SD) days. One month follow up complications in conventional group were more as compared to phenytoin group. Conclusion: Topical phenytoin dressing helps in better granulation tissue formation and better graft take up than the conventional dressing. Hospital stay and post-operative complications were less in topical phenytoin dressing group as compared to conventional dressing group. Conflict of interest: Nil Source of funding: Nil

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Section: Discussionsupporting

confidence: 78%

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

Sandhu¹,

Singh²,

Banga³

et al. 2018

Int. J. Orthop. Sci.

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“…This can be minimized by using phenytoin only instead of phenytoin sodium. 6,26,27 Hypertrophic granulation tissue was reported in two studies. 19,20 This can be prevented by stopping the treatment when the granulation tissue covers the wound bed.…”

Section: Discussionmentioning

confidence: 96%

“…Phenytoin improves wound healing even in these subsets of patients due to its multimodal action. The improved wound healing using topical phenytoin amongst diabetic ulcers is elaborated in a study conducted by Kodela et al 26 Topical phenytoin is well tolerated with minimal side effects.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of topical phenytoin in the management of traumatic wounds

Kumar

Vasudeva

Rao

et al. 2021

Journal of Clinical Orthopaedics and Trauma

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“…Phenytoin is well tolerated with minimal side effects, and systemic absorption of phenytoin is negligible [24,25]. No hypersensitivity reactions to phenytoin have been reported [26].…”

Section: Discussionmentioning

confidence: 97%

From Seizures to Wounds: The Potential of Phenytoin in Traumatic Wound Management

Babu

Sekhar

Vishnu

2023

Int J Pharm Pharm Sci

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Objective: Phenytoin is a medication primarily used to treat seizures, but it has been discovered to have the potential for wound healing due to its ability to increase collagen production, promote new blood vessel growth, reduce inflammation, fight infections, and encourage new skin growth. These effects are particularly useful for healing chronic wounds like pressure ulcers, diabetic ulcers, traumatic wounds, and venous ulcers. Methods: This is a two-year prospective study conducted between January 2020 and December 2022 at the Government General Hospital in Kurnool. A study was conducted on 60 patients with traumatic wounds, dividing them into two groups. One group received topical phenytoin dressing, while the other received normal saline dressing. The study compared wound surface area, granulation tissue percentage, pain ratings on the visual analog scale, and healing time between the groups on day 14 and day 21. Results: On day 0, cases and controls had similar wound surface areas (62.17±25.74 cm2 and 62.14±21.57 cm2, respectively) and VAS scores (8.81±1.22 and 8.88±1.52). By day 14, cases had significantly smaller wound surface areas (41±32.32 cm2), a higher percentage of granulation tissue (75.56±7.30%), and lower VAS scores (4.57±1.78) compared to controls (53.28±25.33 cm2, 58.45±7.01%, and 6.32±1.02, respectively). By day 21, cases had even smaller wound surface areas (28.3±31.75 cm2), a higher percentage of granulation tissue (93±3.46%), and lower VAS scores (2.78±0.42) compared to controls (40.34±34.23 cm2, 72.56±5.05%, and 4.82±1.27, respectively). The time for wound healing was significantly shorter for cases (22.76±7.28 d) compared to controls (32.64±9.31 d). On day 21, negative cultures were found in 80% of wounds in the study group and 50% of wounds in the control group, with a statistically significant difference (P-value<0.05). Conclusion: Topical phenytoin dressing had positive effects on wound healing by increasing the rate of granulation tissue formation, providing better pain relief, and shortening the healing time. It was found to be a safe, effective, and cost-effective option for wound healing due to its various mechanisms. The study highlights the significance of phenytoin in treating traumatic wounds, particularly in patients with limited access to expensive wound-healing medications.

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Out Come of Topical Phenytoin in the Management of Diabetic Ulcers

Cited by 4 publications

References 63 publications

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

Outcomes of topical phenytoin in the management of traumatic wounds

From Seizures to Wounds: The Potential of Phenytoin in Traumatic Wound Management

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