Out of Breath: Asthma in Humans and Their Animals

Hufnagl, Karin; Hirt, Reinhard; Robibaro, B.

doi:10.1007/978-3-319-47007-8_5

Cited by 6 publications

(7 citation statements)

References 26 publications

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“…This is done by whole-body plethysmography in asthma research (Fig. 1 ) [ 39 ]. In food allergy and anaphylaxis research, novel techniques were developed allowing the in-vivo monitoring of effects by allergen challenges, and, in accordance with the 3R principle, networks are formed to share tissues [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a readout for airway hyperreactivity and lung resistance, mice were exposed to increasing concentration of methacholine and monitored either by whole-body plethysmography (Fig. 1 , from [ 39 ]) [ 29 , 34 , 40 ] or by surgically implanted means [ 23 , 24 , 27 ]. Studies investigating the mechanisms at the very start of allergic sensitization demonstrated that B-cells are dispensable for the primary CD4 + T-cell response, but crucial for expansion of primed Th2 cells and generation of central memory [ 28 ▪▪ ], ILC 2 were not an early source of Th2 cytokines, but contributed to allergic inflammation [ 26 ] together with IL-33 derived from monocytes [ 24 ], IL-23 secreted by bronchial epithelial cells [ 32 ], placenta growth factor [ 27 ] and lysophophatidylcholine [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…The experimental principle is identical to the human diagnostic test. Reproduced with permission from Springer [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAnimal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed.Recent findingsWhile domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple and peach in food allergy research were used. Novel engineered mouse models such as a mouse with a T-cell receptor for house dust mite allergen Der p 1, or with transgenic human hFcγR genes, facilitated the investigation of single molecules of interest. Whole-body plethysmography has become a state-of-the-art in-vivo readout in asthma research. In food allergy and anaphylaxis research, novel techniques were developed allowing real-time monitoring of in-vivo effects following allergen challenge. Networks to share tissues were established as an effort to reduce animal experiments in allergy which cannot be replaced by in-vitro measures.SummaryNatural and artificial animal models were used to explore the pathophysiology of asthma, food allergy and anaphylaxis and to improve prophylactic and therapeutic measures. Especially the novel mouse models mimicking molecular aspects of the complex immune network in asthma, food allergy and anaphylaxis will facilitate proof-of-concept studies under controlled conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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“…In horses, allergen hypersensitivity leads to cutaneous symptoms, that is eczema or urticaria, and/or to respiratory symptoms in form of chronic coughing or recurrent airway obstruction (RAO) . In equine RAO, the exposure to allergens from hay and straw dust and induced symptoms are associated with increased plasma histamine levels; however, at least in case of the fungus Aspergillus , in vitro IgE diagnosis and intradermal IgE levels do not support IgE‐mediated mechanisms .…”

Section: Introductionmentioning

confidence: 99%

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Einhorn

Hofstetter

Brandt

et al. 2018

Allergy

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BackgroundCompanion animals are also affected by IgE‐mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles.MethodsCustom‐designed allergen microarray was produced on the basis of the ImmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity. The included horse patients were diagnosed for eczema due to insect bite hypersensitivity, chronic coughing, recurrent airway obstruction and urticaria or were clinically asymptomatic.ResultsHorses showed individual IgE‐binding patterns irrespective of their health status, indicating sensitization. In contrast to European and Japanese human sensitization patterns, frequently recognized allergens were Aln g 1 from alder and Cyn d 1 from Bermuda grass, likely due to specific respiratory exposure around paddocks and near the ground. The most prevalent allergen for 72.5% of the tested horses (37/51) was the 2S‐albumin Fag e 2 from buckwheat, which recently gained importance not only in human but also in horse diet.ConclusionIn line with the One Health concept, covering human health, animal health and environmental health, allergen microarrays provide novel information on the allergen sensitization patterns of the companion animals around us, which may form a basis for allergen‐specific preventive and therapeutic concepts.

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“…Die orale Kombinationstherapie mit Propentofyllin und Prednisolon bewirkte bei Katzen mit entzündlichen Bronchialerkrankungen nach einem Zeitraum von 8 Wochen im Vergleich zur alleinigen Behandlung mit Prednisolon eine signifikante Besserung des Hustens, des Atemmusters und der radiologischen Befunde [90]. Bronchodilatatoren können die Therapie somit gezielt ergänzen und sind auch zur Inhalation in Form von Mono-und Kombinationspräparaten verfügbar (Fluticason/Salmeterol) [ [101]. Experimentell ließ sich mit der RIT bei betroffenen Katzen zudem eine Verminderung der eosinophilen Atemwegsentzündung nachweisen [98].…”

Section: Bronchodilatatorenunclassified

Felines Asthma und chronische Bronchitis – Übersicht zu Diagnostik und Therapie

Grotheer

Schulz²

2019

Tierarztl Prax Ausg K

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ZusammenfassungFelines Asthma und feline chronische Bronchitis gelten als die häufigsten chronischen Erkrankungen der unteren Atemwege bei Katzen und werden oft als chronische Bronchialerkrankungen zusammengefasst. Beim felinen Asthma wird ursächlich eine Hypersensitivitätsreaktion Typ I vermutet, bei der chronischen Bronchitis ist die Ätiologie noch weitgehend unbekannt. Betroffene Katzen können Husten, Dyspnoe und Atemgeräusche zeigen. Beide Krankheitsbilder werden zurzeit anhand des zytologischen Zellbildes einer durch Bronchoalveolarlavage gewonnenen Probe definiert und können sich in Ursache, Behandlung und klinischem Verlauf unterscheiden. Die Diagnosestellung beinhaltet den Ausschluss anderer Grunderkrankungen in Kombination mit dem Nachweis einer nicht infektiösen, eosinophilen oder neutrophilen Entzündung der Atemwege. Neben der etablierten Therapie mit oral oder inhalativ applizierten Glukokortikoiden und Bronchodilatatoren werden in dem Artikel auch neuere therapeutische und diagnostische Ansätze vorgestellt.

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Out of Breath: Asthma in Humans and Their Animals

Cited by 6 publications

References 26 publications

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Felines Asthma und chronische Bronchitis – Übersicht zu Diagnostik und Therapie

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