Out-of-hospital deliveries: A case-control study

Diana, Lima; Glaucia, Lima; Adriana, Cersosimo; Figueiredo, Israel

doi:10.5152/turkpediatriars.2018.6269

Cited by 11 publications

(10 citation statements)

References 23 publications

(14 reference statements)

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“…Risk factors for planned or unplanned out-of-hospital births have been widely explored, highlighting contribution of factors including ethnic group, age, parity, prenatal care, education, labour duration, smoking or distance to maternity center [3, 11, 12, 20]. Perinatal morbidity and mortality in planned and unplanned out-of-hospital births was associated with several factors, including postpartum hemorrhage, puerperal complications, low birth weight, polycythemia, and hypothermia [9, 10, 12, 13, 19]. Unsurprisingly, as reported in our cohort, prematurity worsens perinatal prognosis [21].…”

Section: Discussionmentioning

confidence: 99%

“…Hypothermia is the most frequently described adverse outcome [7, 8]. However, knowledge is limited by the small sample size of the previous studies, and most of them had insufficient power to accurately assess adverse events [12, 13]. Thus, perinatal outcome in unplanned out-of-hospital births remains unclear and large multicentric cohorts are needed to examine perinatal morbidity and mortality and their determinants.…”

Section: Introductionmentioning

confidence: 99%

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Unplanned out-of-hospital birth and risk factors of adverse perinatal outcome: findings from a prospective cohort

Javaudin

Hamel

Legrand³

et al. 2019

Scand J Trauma Resusc Emerg Med

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Background In France, while most babies are delivered at hospital, emergency medical services (EMS) weekly manage calls for unplanned out-of-hospital births. The objective of our study was to describe neonatal morbidity and mortality, defined as death or neonatal intensive care unit hospitalization at Day 7, in a prospective multicentric cohort of unplanned out-of-hospital births. Methods We prospectively analyzed out-of-hospital births from 25 prehospital EMS units in France. The primary outcome was neonatal morbidity and mortality, and the secondary outcome was risk factors associated with neonatal morbidity and mortality. A univariate logistic regression was first made, followed by a multivariate logistic regression with backward selection. Results From October 2011 to August 2018, a total of 1670 unplanned out-of-hospital births were included. Of these, 1652 (99.2%) were singleton and 1537 (93.5%) had prenatal care. Maternal mean age of the study population was 30 ± 5.5 (range 15 to 48). The majority of women were multiparous, but 13% were nulliparous. Overall, 45.3% of these unplanned out-of-hospital births were medically-driven, either by phone during medical regulation (12.5%) or on scene by the prehospital emergency medical service units (32.9%). The prevalence of neonatal morbidity and mortality was 6.3% ( n = 106) after an unplanned out-of-hospital birth (death before Day 7: n = 20; 1.2%). The multivariate logistic regression found that multiparity (adjusted Odds Ratio = 70.7 [4.7–1062]), prematurity (adjusted Odds Ratio = 6.7 [2.1–21.4]), maternal pathology (adjusted Odds Ratio = 2.8 [1.0–7.5]) and hypothermia (adjusted Odds Ratio = 2.8 [1.1–7.6]) were independent predictive factors of neonatal morbidity and mortality. Conclusions Our study assessed for the first time risk factors for adverse perinatal outcome in a large and multicenter cohort of unplanned out-of-hospital births. We have to improve temperature management in the out-of-hospital field and future trials are required to investigate strategies to optimize newborns management in the prehospital area. Electronic supplementary material The online version of this article (10.1186/s13049-019-0600-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unplanned out-of-hospital birth and risk factors of adverse perinatal outcome: findings from a prospective cohort

Javaudin

Hamel

Legrand³

et al. 2019

Scand J Trauma Resusc Emerg Med

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“…Although childbirth care in health facilities or accompanied by skilled health personnel is encouraged, in various regions of the world, especially in low-income countries, home births represent more than 50% of the total number of births [ 9 , 10 ]. Higher rates of maternal and perinatal complications and deaths have been described in home births, as well as difficulties in managing complications due to the need for transfer to a health facility [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with home births in Peru 2015–2017: A cross-sectional population-based study

Hernández-Vasquéz

Chacón-Torrico

Vargas-Fernández

et al. 2021

Heliyon

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Background Higher rates of maternal complications and deaths have been described in home births. However, few local studies have evaluated factors associated with home births in Peru. The study aims to determine the prevalence and factors associated with home birth in the Peruvian population. Methods A population-based analytical cross-sectional study was conducted using pooled data from the 2015–2017 Peruvian Demographic and Health Surveys. A logistic regression model was performed to calculate crude and adjusted odds ratios (aOR) for the association between sociodemographic and mother-related factors and home births. Results Seven out of every 100 births were home births. Living in a rural area (aOR = 3.10; 95% CI: 2.52–3.81), having a primary or secondary educational level, belonging to a medium or low wealth tertile, being from the rest of the Coast, Andean or Amazon regions, the second or greater number of birth order and considering the distance to the health center as problematic (aOR: 1.32; 95% CI: 1.17–1.48) were found to be associated with a higher probability of home births. Contrarily, being in the age groups of 25–34 and 35–39 years old, having a multiple pregnancy and giving birth to a medium (aOR: 0.88; 95% CI: 0.78–1.00) or large-sized newborn (aOR = 0.81; 95% CI: 0.72–0.93) were associated with a lower probability of presenting home births. Conclusions Sociodemographic factors are associated with home births in Peru. Further study of these factors is required to develop strategies specific to the needs of the population of childbearing age.

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“…Data for blood PBMC differential cell counts and animal study were displayed as boxplots, which indicate the median, interquartile range, and the largest and smallest values for the number of experiments indicated. The normality of distribution was determined using the Kolmogorov–Smirnov or Shapiro–Wilk tests ( Diana et al, 2018 ). Correlations were determined using Pearson’s correlation analysis.…”

Section: Methodsmentioning

confidence: 99%

Increased expressions of CD123, CD63, CD203c, and Fc epsilon receptor I on blood leukocytes of allergic asthma

Xie

Chen

Zhang

et al. 2022

Front. Mol. Biosci.

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Background: Altered basophil identification markers have been discovered to associate with allergic asthma (AA) in recent years. However, little is known about the expression of basophil markers in blood granulocytes.Aim: To parallel test blood basophils in peripheral blood mononuclear cell (PBMC) and granulocyte populations of patients with AA and AA combined with allergic rhinitis (ARA)Methods: The expressions of surface molecules were determined via flow cytometry. CD123 expressing cells in blood were isolated using a cell sorting technique, and mouse AA models were employed for in vivo study.Results: The numbers of CD123+HLA-DR− cells in the granulocytes of AA and ARA patients markedly increased. However, only 49.7% of CD123+HLA-DR− cells in granulocytes and 99.0% of CD123+HLA-DR− cells in PBMCs were basophils. Almost all CD123+HLA-DR− cells expressed CD63 regardless in granulocytes or PBMC. The numbers of CD63, Fc epsilon receptor I (FcεRI), and CD203c expressing cells markedly enhanced in CD123+HLA-DR− granulocytes of AA and ARA patients. Mean fluorescence intensity (MFI) of CD63 and CD203c expressions on CD123+HLA-DR− PBMC and granulocytes of AA and ARA patients dramatically elevated. House dust mite extract (HDME) and Artemisia sieversiana wild allergen extract (ASWE) enhanced the numbers of CD63+CD123+HLA-DR− granulocytes and PBMC and the MFI of CD203c expression on CD123+HLA-DR− granulocyte of AA and ARA patients. Histamine, tryptase, and PGD2 enhanced proportions of CD123+ KU812 cells. ASWE- and HDME-induced AA mice showed upregulated CD63 expression on basophils. In conclusion, upregulated expressions of CD123, CD203c, CD63, and FcεRIα in PBMC and granulocytes of patients with AA and ARA suggest that CD123+HLA-DR− cells may contribute to the development of AA and ARA.

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Out-of-hospital deliveries: A case-control study

Cited by 11 publications

References 23 publications

Unplanned out-of-hospital birth and risk factors of adverse perinatal outcome: findings from a prospective cohort

Unplanned out-of-hospital birth and risk factors of adverse perinatal outcome: findings from a prospective cohort

Factors associated with home births in Peru 2015–2017: A cross-sectional population-based study

Increased expressions of CD123, CD63, CD203c, and Fc epsilon receptor I on blood leukocytes of allergic asthma

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