I also received a lot of support outside of work from my family, family-in-law and friends. I want to thank them for their genuine interest in my research, for sharing my enthusiasm when I published a paper or reached another milestone in my Ph.D., for offering me distraction from the Ph.D. and for cheering me up when necessary. A special word of thanks goes out to my parents and sisters, Leen and Tine, for all their heartfelt encouragements which often kept me going and for actively supporting me all my life. And finally, I would like to thank my soon to be husband, Wouter, for always believing in me, for putting up with me at times when I was totally stressed out, for your understanding, your support and your insights whenever I needed them. Thank you for everything. Hanne Pollaris Hasselt, March 2017 A Results insertion methods B Detailed results: ILS algorithm on small-size instances C Detailed results: minimization of total distance D Detailed results: minimization of total transport cost