In this paper, we proposed a technique to mitigate the Inter-Carrier Interference (ICI) in Multiple-Input Multiple-Output OFDM Systems (MIMO-OFDM) which is a major bottleneck in wireless communication system. Previously the number of frame architectures and different models of channels are used to diminish this drawback of OFDM but the calculations for these models are more difficult. Therefore, we implemented low complexity ICI mitigation for MIMO-OFDM systems beneath the acceptance of channels which are linear time varied. It decreases the complication of ICI suppression from2 log O K M NM NM MK K + + + to ( ) ( ) ( ) 3 2 2 2 2 2 log , O K M NM NM N M K + + + + here K indicates subcarrier number, N indicates transmitters number and M indicates receivers number. Depends on Timevariant channel methods, channel estimation is needed. Linear time-invariant channels are easily estimated by the time-domain synchronous OFDM receiver. Therefore, these receivers are convenient for our implemented work. An experimental result provides a comparative analysis by using QPSK and 16-QAM modulation techniques to prove the implemented methodology performance. Keywords: inter carrier interference (ICI), multiple-input multiple-output OFDM systems (MIMO-OFDM), OFDM, time domain synchronous OFDM