Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

Lee, Hyeongrae; Kim, E.S.; Choi, Chang Won; Seo, Hye Kyung; Shin, Myoung Jin; Bok, Jeroen; Cho, J.E.; Kim, C.J.; Shin, Ji-Hyun; Kim, T.S.; Song, Kyoung Ho; Park, Kyoung Un; Kim, B.I.; Kim, H.B.

doi:10.1016/j.jhin.2014.04.003

Cited by 20 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MRSA transmission is already known to be highly efficient in nurseries due to the routine care practices and a lower awareness by HCWs of general infection control measures. 15 Unfortunately, our ASC program was not extended to the nursery, preventing us from drawing definitive conclusions.…”

Section: Discussionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus nasal colonization in a level III neonatal intensive care unit: Incidence and risk factors

Giuffrè¹,

Amodio²,

Bonura³

et al. 2015

American Journal of Infection Control

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus nasal colonization in a level III neonatal intensive care unit: Incidence and risk factors

Giuffrè¹,

Amodio²,

Bonura³

et al. 2015

American Journal of Infection Control

View full text Add to dashboard Cite

“…Ever since its emergence in 2000 in the United States, prevalence ofST8 (USA300) has led to a high burden of SSTIs globally[ 23 ], as witnessed by S . aureus clone outbreaks among SSTIs in Japan, Korea, Singapore and Europe[ 11 , 24 – 27 ].We found one ST8 isolate from a non-native patient in our study as ST8-SCC mec I-t5160 with lukS/F-PV positive. However, CC8 (ST8, ST239, ST630 and ST1821) was found in 10 isolates, of which 2 (1 MRSA and 1MSSA) were from non-native patients and 8 (2 MRSA and 6 MSSA) were from native patients.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Staphylococcus aureus Isolated from Non-Native Patients with Skin and Soft Tissue Infections in Shanghai

Hou

Yang

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

Background Staphylococcus aureus is one predominant cause of skin and soft-tissue infections (SSTIs), but little information exists regarding the characterization of S. aureus from non-native patients with SSTIs in China.MethodsIn this study, we enrolled 52 non-native patients with S. aureus SSTIs, and 65 native control patients with S. aureus SSTIs in Shanghai. 52 and 65 S. aureus isolates were collected from both groups, respectively. S. aureus isolates were characterized by antimicrobial susceptibility testing, toxin gene detection, and molecular typing with sequence type, spa type, agr group and SCCmec type.ResultsMethicillin-resistant S. aureus (MRSA) was detected in 8 non-native patients and 14 native patients with SSTIs. Overall, antimicrobial susceptibilities of S. aureus isolated from non-native patients were found higher than those from native patients. CC59 (ST338 and ST59) was found in a total of 14 isolates (4 from non-native patients; 10 from native patients), 9 of which were carrying lukS/F-PV (3 from non-native patients; 6 from native patients). ST7 was found in 12 isolates and all 12 isolates were found in native patients. The livestock-associated clone ST398 was found in 11 isolates (6 from non-native patients; 5 from native patients), and 5 ST398 lukS/F-PV-positive methicillin-susceptible S. aureus (MSSA) were all discovered among non-native patients. The molecular epidemiology of S. aureus isolated from non-native patients was quite different from those from native patients. lukS/F-PV was more frequent in isolates originating from non-native patients with SSTIs compared to native patients (31 vs. 7, P <0.0001).ConclusionsCC59 was the most common clonal complex among patients with SSTIs in Shanghai. The other most common sequence types were ST7 and Livestock ST398. The molecular epidemiology of S. aureus isolated from non-native patients was quite different from those from native patients. S. aureus isolated from non-native patients was more likely to carry lukS/F-PV.

show abstract

“…We assumed that the contamination was rather caused by an unfavorable work process. e ad hoc discontinuation of the hydrotherapy application after the environmental samples became positive for MRSA led to a rapid outbreak cessation as in other previously reported outbreaks [14][15][16].…”

Section: Single-hospital Outbreakmentioning

confidence: 53%

Epidemiologic and Molecular Investigation of a MRSA Outbreak Caused by a Contaminated Bathtub for Carbon Dioxide Hydrotherapy and Review of the Literature

Baier

Ebadi

Mett

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Introduction. Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for infections in patients both inside and outside of the hospital and causes outbreaks. Here, we demonstrate the characteristics and control of a MRSA outbreak related to a carbon dioxide hydrotherapy bathtub. Methods. We conducted an outbreak investigation and performed a molecular typing of the outbreak strains with pulsed-field gel electrophoresis (PFGE). In addition, we reviewed PubMed and the Outbreak Database for MRSA outbreaks related to hydrotherapy or other bathing activities. Results. Four patients acquired nosocomial MRSA during the 4-week outbreak period. Environmental sampling revealed the presence of MRSA in the bathtub used for hydrotherapy. The environmental and the patients’ isolates showed an indistinguishable restriction pattern in the PFGE. Subsequent discontinuation of bathing stopped the outbreak. The literature search found 9 MRSA outbreak reports related to bathing activities or hydrotherapy. Conclusion. The epidemiologic outbreak investigation together with the molecular findings suggests monoclonal spread of MRSA due to surface contamination of the bathtub. After enhancing the disinfection and cleaning process accompanied by staff training with respect to hand hygiene, no further cases occurred. Standardized and best practice cleaning and disinfection protocols are crucial, especially in critical facilities such as hydrotherapy units. Regular environmental sampling is helpful to monitor these processes and to detect potential contamination.

show abstract

Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

Cited by 20 publications

References 37 publications

Methicillin-resistant Staphylococcus aureus nasal colonization in a level III neonatal intensive care unit: Incidence and risk factors

Methicillin-resistant Staphylococcus aureus nasal colonization in a level III neonatal intensive care unit: Incidence and risk factors

Characterization of Staphylococcus aureus Isolated from Non-Native Patients with Skin and Soft Tissue Infections in Shanghai

Epidemiologic and Molecular Investigation of a MRSA Outbreak Caused by a Contaminated Bathtub for Carbon Dioxide Hydrotherapy and Review of the Literature

Contact Info

Product

Resources

About