Outbreak of Bloodstream Infection With the Mold <i>Phialemonium</i> Among Patients Receiving Dialysis at a Hemodialysis Unit

Clark, Thomas A.; Huhn, Gregory; Conover, Craig; Cali, Salvatore; Arduino, Matthew J.; Hajjeh, Rana; Brandt, Mary E.; Fridkin, Scott K.

doi:10.1086/508822

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…They are both rare causes of disease in humans, although they can cause skin lesions, keratitis, onychomycosis, fungemia, endocarditis, sinusitis and pulmonary infections. 12,14,[21][22][23] Anti-fungal susceptibility data are very limited, but often the minimal inhibitory concentration (MIC) of amphotericin, fluconazole, itraconazole and echinocandins is high, whereas the MIC of voriconazole and posaconazole is low. 23 Despite the high proportion of positive isolates, we did not observe any invasive disease subsequent to isolation of these organisms, which suggests that, when isolated from the BAL, these organisms likely do not require any specific prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Post-transplant Colonization With Non-Aspergillus Molds and Risk of Development of Invasive Fungal Disease in Lung Transplant Recipients

Silveira¹,

Kwak²,

Paterson³

et al. 2008

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Post-transplant Colonization With Non-Aspergillus Molds and Risk of Development of Invasive Fungal Disease in Lung Transplant Recipients

Silveira¹,

Kwak²,

Paterson³

et al. 2008

The Journal of Heart and Lung Transplantation

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“…Water quality, membrane reuse, and infection control are key areas of safety risk, and adverse events have been reported in each area (7)(8)(9)(10)(11)(12)(13)(14)(15). Infection control risks, such as design flaws (9), inadequate hand hygiene, and faulty machine and equipment disinfection (7,8,15,16), have been associated with outbreaks of unusual biopathogens (8,9,13), as well as transmission of vancomycin-resistant enterococcus and hepatitis B and C viruses. The regulations and safety guidelines for water quality, reuse, and infection control are established and readily available (14,17).…”

Section: Dialysis Safety Prioritiesmentioning

confidence: 99%

“…In addition to clinical safety, failure to follow protocol has also contributed to technical mistakes and lapses in infection control (1,2,(4)(5)(6)(7)(8)(9). Among other risks, protocol departures can result in critical errors in dialysis reuse, dialysate composition, and water purification, with catastrophic effects on an entire facility (7)(8)(9)(10)(11)(12)(13).…”

Section: Failure To Follow Policies and Protocolsmentioning

confidence: 99%

Patient and Facility Safety in Hemodialysis

Garrick

Kliger

Stefanchik

2012

Clinical Journal of the American Society of Nephrology

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SummaryPatient safety is the foundation of high-quality health care. More than 350,000 patients receive dialysis in the United States, and the safety of their care is ultimately the responsibility of the facility medical director. The medical director must establish a culture of safety in the dialysis unit and lead the quality assessment and performance improvement process. Several lines of investigation, including surveys of patients and dialysis professionals, have helped to identify important areas of safety risk in dialysis facilities. Among these are lapses in communication, medication errors, patient falls, errors in machine and membrane preparation, failure to follow established policies, and lapses in infection control. The quality assessment and performance improvement process should include a dedicated safety team to focus on specifically identified areas of risk and to establish outcome goals guided by best practices and agreed-upon measures of success. A safety questionnaire can be given to patients and staff and the responses evaluated to improve understanding of the prevailing attitudes and concerns about safety. By sharing these results, openly acknowledging the challenges, and using a blame-free root cause process to identify action plans, the facility can begin to establish a culture of safety.

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“…[ 30 ], Phialemonium spp. [ 31 – 34 ], and Scedosporium spp. [ 35 – 37 ], have been particularly associated with HAI in patients with hematologic diseases.…”

Section: Etiologic Agents Of Haimentioning

confidence: 99%

CouldHistoplasma capsulatumBe Related to Healthcare-Associated Infections?

Carreto-Binaghi

Damasceno

Pitangui

et al. 2015

BioMed Research International

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Healthcare-associated infections (HAI) are described in diverse settings. The main etiologic agents of HAI are bacteria (85%) and fungi (13%). Some factors increase the risk for HAI, particularly the use of medical devices; patients with severe cuts, wounds, and burns; stays in the intensive care unit, surgery, and hospital reconstruction works. Several fungal HAI are caused by Candida spp., usually from an endogenous source; however, cross-transmission via the hands of healthcare workers or contaminated devices can occur. Although other medically important fungi, such as Blastomyces dermatitidis, Paracoccidioides brasiliensis, and Histoplasma capsulatum, have never been considered nosocomial pathogens, there are some factors that point out the pros and cons for this possibility. Among these fungi, H. capsulatum infection has been linked to different medical devices and surgery implants. The filamentous form of H. capsulatum may be present in hospital settings, as this fungus adapts to different types of climates and has great dispersion ability. Although conventional pathogen identification techniques have never identified H. capsulatum in the hospital environment, molecular biology procedures could be useful in this setting. More research on H. capsulatum as a HAI etiologic agent is needed, since it causes a severe and often fatal disease in immunocompromised patients.

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Outbreak of Bloodstream Infection With the Mold Phialemonium Among Patients Receiving Dialysis at a Hemodialysis Unit

Cited by 14 publications

References 19 publications

Post-transplant Colonization With Non-Aspergillus Molds and Risk of Development of Invasive Fungal Disease in Lung Transplant Recipients

Post-transplant Colonization With Non-Aspergillus Molds and Risk of Development of Invasive Fungal Disease in Lung Transplant Recipients

Patient and Facility Safety in Hemodialysis

CouldHistoplasma capsulatumBe Related to Healthcare-Associated Infections?

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