Outbreak of Burkholderia cepacia complex bacteremia in a chemotherapy day care unit due to intrinsic contamination of an antiemetic drug

Abstract

This outbreak was thus linked to intrinsic contamination of medication vials. We acknowledge a delay in identifying the source as we were concentrating more on human errors in medication preparation and less on intrinsic contamination. We recommend that in an event of an outbreak, unopened vials be cultured at the outset.

Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit

“…Although pulsed field gel electrophoresis (PFGE) has historically been used to define outbreaks and clusters (Dizbay et al, 2009;De Smet et al, 2013), the technique is cumbersome, requiring dedicated equipment that is not widely available (Machado et al, 2014). Many recent studies have explored the potential of MLST as a tool for detailed investigation of outbreaks (Mali et al, 2017;Singhal et al, 2015;Wang et al, 2015;Sails et al, 2003). Also, studies comparing the results of MLST schemes to PFGE have shown 100% agreement between the two techniques (Machado et al, 2014).…”

An Outbreak of Burkholderia cepacia Bacteremia in a Neonatal Intensive Care Unit

“…In a study presented at the 15th International Congress on Infectious Diseases, an outbreak of hospital-acquired B. cepacia bloodstream infections was traced to the use of intravenous solution as multiple-dose for catheter flushing in Cambodia [17]. Burkholderia cepacia, as a cause of nosocomial outbreaks has also been isolated from unused antiemetic for IV use [18], moisturizing body milk used in ICUs [19], mannitol solution used for irrigation in urologic surgery [20], sink drains [21], water for injection [22] and ultrasound gel [23].…”

RefractoryBurkholderia cepaciabacteraemia from a consolidation pneumonia lasting more than 7 weeks, successfully treated with systemic antibiotics and nebulised meropenem

“…BCC survives and multiplies in aqueous hospital environments, including detergent solutions and intravenous fluids, where it may persist for long periods. Outbreaks of BCC septicemia have been documented in paediatric intensive care units,12 13 oncology units14 and haemodialysis unit 15. Furthermore, some of BCC’s virulence factors enables it to exist intracellularly, making eradication a challenge, particularly in CF patients where the high NaCl content of its pulmonary surface deactivates some of the endogenous bactericidal substances produced by the respiratory epithelium 11…”