Outbreak of Empedobacter brevis endophthalmitis after cataract extraction

Janknecht, P.; Schneider, Christian; Neß, Thomas

doi:10.1007/s00417-002-0435-5

Cited by 19 publications

(15 citation statements)

References 25 publications

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“…as demonstrated by its 98% similarity with GU062422.1. 49 Empedobacter is a known human pathogen . Strains of this species have been found to develop anaerobic ammonium oxidation yielding nitrate as metabolite with utilization of an electrode as terminal electron acceptor .…”

Section: Resultsmentioning

confidence: 99%

“…49 Empedobacter is a known human pathogen. 53,54 Strains of this species have been found to develop anaerobic ammonium oxidation yielding nitrate as metabolite with utilization of an electrode as terminal electron acceptor. 55 Ability of Empedobacter for undergoing this metabolism is thought to reside in the advantage this species gains over other heterotrophs when it transfers electrons directly to the electrode.…”

Section: Diversity and Relative Abundance Of Bacterial Speciesmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial community structure of a lab‐scale anammox membrane bioreactor

González‐Martínez

Osorio

Rodríguez-Sánchez

et al. 2014

Biotechnology Progress

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Autotrophic nitrogen removal technologies have proliferated through the last decade. Among these, a promising one is the membrane bioreactor (MBR) Anammox, which can achieve very high solids retention time and therefore sets a proper environment for the cultivation of anammox bacteria. In this sense, the MBR Anammox is an efficient technology for the treatment of effluents with low organic carbon and high ammonium concentrations once it has been treated under partial nitrification systems. A lab-scale MBR Anammox bioreactor has been built at the Technological University of Delft, The Netherlands and has been proven for efficient nitrogen removal and efficient cultivation of anammox bacteria. In this study, next-generation sequencing techniques have been used for the investigation of the bacterial communities of this MBR Anammox for the first time ever. A strong domination of Candidatus Brocadia bacterium and also the presence of a myriad of other microorganisms that have adapted to this environment were detected, suggesting that the MBR Anammox bioreactor might have a more complex microbial ecosystem that it has been thought. Among these, nitrate-reducing heterotrophs and primary producers, among others, were identified. Definition of the ecological roles of the OTUs identified through metagenomic analysis was discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Diversity and Relative Abundance Of Bacterial Speciesmentioning

confidence: 99%

Bacterial community structure of a lab‐scale anammox membrane bioreactor

González‐Martínez

Osorio

Rodríguez-Sánchez

et al. 2014

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…Forensic methods to determine the source of these outbreaks use a combination of phenotypic (routine culture, biochemical profiles, antibiotic susceptibility patterns) 8,10,17 and molecular (real-time polymerase chain reaction, restriction fragment length polymorphism) fingerprinting and pulsed-field gel electrophoresis (PFGE). 8,17 Conventional methods of culture and susceptibility were the most common and least reliable in comparing isolates from the patient and external sources such as solutions, lenses, or medications. Molecular fingerprinting using PFGE is the gold standard and the most reliable method for confirming isolate similarity and/or outbreak origin.…”

Section: Discussionmentioning

confidence: 99%

Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

Pathengay

Flynn

Isom

et al. 2012

Journal of Cataract and Refractive Surgery

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“…Many clusters reported in the literature tend to originate from a distinct infective source and occur over a relatively short time period of days to weeks. 7,8 With a readily identifiable source of infection, preventing further episodes simply involves eradicating that source. We present our experience of managing an atypical outbreak of endophthalmitis over a 7-month period with no identifiable source of infection.…”

Section: Introductionmentioning

confidence: 99%

A model for the management of an atypical endophthalmitis outbreak

Anderson

Lee

Shafi

et al. 2004

Eye

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Purpose of study To present a model for the assessment, investigation, and management of an atypical outbreak of infectious endophthalmitis of indeterminate aetiology. Methods A published statistical model was used to determine when the case-load constituted an outbreak. Intraocular surgery was discontinued and a multidisciplinary infection control team was formed aimed at identifying potential causative factors among the following categories: environment around theatre, preoperative preparation, intraoperative theatre practices, intraoperative surgical practices, postoperative practices, equipment maintenance guidelines, cleaning/ sterilization practices, and microbiological screening. Results Five cases of postoperative endophthalmitis developed following uncomplicated phacoemulsification cataract surgery by different surgeons over a 7-month period. Despite full investigation no single focus of infection could be determined. Four out of five cases were culture positive. Three grew Streptococcus viridans of different strains. The fourth culture grew Staphylococcus aureus. In the absence of a single causative factor, it was postulated the combined effect of multiple potential factors may have led to an increased bacterial load and subsequent infection rate. Improved practices were initiated including new cleaning protocols to combat the build-up of debris on phacoemulsification instruments. Cataract surgery was resumed with 3-monthly microbiological monitoring. There have been no further cases in the 12 months following the changes. ConclusionOutbreaks of endophthalmitis typically present over a short time period and could often be attributed to a single infective cause. We present our experience of detecting and managing this cluster and recommend a 'ground-up' multidisciplinary model to manage future outbreaks of this devastating condition.

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Outbreak of Empedobacter brevis endophthalmitis after cataract extraction

Cited by 19 publications

References 25 publications

Bacterial community structure of a lab‐scale anammox membrane bioreactor

Bacterial community structure of a lab‐scale anammox membrane bioreactor

Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

A model for the management of an atypical endophthalmitis outbreak

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