Outbreak of<i>Burkholderia cepacia</i>Bacteremia Caused by Contaminated Chlorhexidine in a Hemodialysis Unit

Romero-Gómez, María Pilar; Quiles-Melero, M. I.; García, P. Peña; Altés, A. Gutiérrez; Miguel, M.aJ. García de; Jiménez, C; Valdezate, Sylvia; Nieto, Juan Antonio

doi:10.1017/s0195941700026709

Cited by 19 publications

(5 citation statements)

References 7 publications

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“…16 In addition, caution using locally prepared chlorhexidine solutions or tap water in clinical settings is needed because outbreaks associated with these preparations have been documented. 17 There are several pathways (eg, decolonization of patient skin, removal of transient flora from hands of healthcare workers who may manipulate CVCs, and decontamination of the patient's environment) 16 by which chlorhexidine cleansing may contribute to the prevention of CVC-associated BSIs. The relative impacts have not been determined, but each potential beneficial effect of chlorhexidine may help to counteract various factors that affect the risk of CVC-associated BSI.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Bloodstream Infections by Use of Daily Chlorhexidine Baths for Patients at a Long-Term Acute Care Hospital

Munoz-Price

Hota

Stemer

et al. 2009

Infect. Control Hosp. Epidemiol.

114

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Section: Discussionmentioning

confidence: 99%

Prevention of Bloodstream Infections by Use of Daily Chlorhexidine Baths for Patients at a Long-Term Acute Care Hospital

Munoz-Price

Hota

Stemer

et al. 2009

Infect. Control Hosp. Epidemiol.

114

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“…Such organisms are additionally among the major contaminants reported in nonsterile pharmaceutical product recalls (Jimenez ; Romero‐Gómez et al . ; Sandle ; Park et al . ).…”

Section: Intrinsic Resistancementioning

confidence: 99%

A review on biocide reduced susceptibility due to plasmid‐borne antiseptic‐resistant genes—special notes on pharmaceutical environmental isolates

Vijayakumar

Sandle

2018

J Appl Microbiol

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Summary Biocides (antiseptics and disinfectants) are widely used in hospitals and pharmaceutical industries for contamination control. The emergence of reduced susceptibility to biocides is the major concern and this is caused by various factors, among which plasmid‐mediated resistance is common. Many publications describe the antibiotic resistance and mechanisms in a clinical setting. However, there are only limited studies available worldwide addressing the molecular mechanisms of biocide resistance in the pharmaceutical sector. In addition, there is a considerable lack of scientific reports regarding minimum inhibitory concentration (MIC) values of typical biocides against pharmaceutical cleanroom environmental isolates. This review analyses the plasmid‐mediated resistance in typical pharmaceutical micro‐organisms and prevalence of biocide‐resistant genes among common clinical and pharmaceutical isolates. This review discusses the MIC values of biocides in pharmaceutical environmental isolates, indicating the importance of the correlation between the presence or absence of biocide‐resistant genes and reduced susceptibility of MIC values. This review recommends that pharmaceutical organizations adopt policies and test methodologies to examine the MICs of common cleanroom biocides against the most common types of cleanroom environmental isolates.

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“…However, previous studies have shown that unopened bottles of 0.5% aqueous solution chlorhexidine were a source of B cepacia infection. In addition, 2.5% chlorhexidine solutions for dialysis machines disinfection were the source of B cepacia outbreak (10,11). We did not isolate B cepacia from the hand antiseptic.…”

Section: Discussionmentioning

confidence: 84%

Repeated Burkholderia cepacia Peritonitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

et al. 2015

West Indian Med J

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Burkholderia cepacia (B cepacia) is a rare opportunistic pathogen in continuous ambulatory peritoneal dialysis (CAPD) peritonitis. We describe the first case of repeated B cepacia CAPD peritonitis, occurring in an outpatient environment, treated with antimicrobial medication without peritoneal catheter removal. B cepacia may lead to repeat infection, therefore, we should insist on catheter removal during each peritonitis episode.

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Outbreak ofBurkholderia cepaciaBacteremia Caused by Contaminated Chlorhexidine in a Hemodialysis Unit

Cited by 19 publications

References 7 publications

Prevention of Bloodstream Infections by Use of Daily Chlorhexidine Baths for Patients at a Long-Term Acute Care Hospital

Prevention of Bloodstream Infections by Use of Daily Chlorhexidine Baths for Patients at a Long-Term Acute Care Hospital

A review on biocide reduced susceptibility due to plasmid‐borne antiseptic‐resistant genes—special notes on pharmaceutical environmental isolates

Repeated Burkholderia cepacia Peritonitis in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

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