Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011

Abstract

Between July 2011 and August 2011, the New Delhi metallo-beta-lactamase 1 (NDM-1) gene was detected in Klebsiella pneumoniae and Escherichia coli isolates obtained from six patients hospitalised in four healthcare facilities in northern Italy. The patient who had been hospitalised in New Delhi, India, from February to May 2011 and subsequently in the Bologna area, Italy, from May to July 2011, may have been the source of the outbreak. Our findings suggest ongoing spread of this carbapenem-resistance gene in Italy and highlight the need for intensive surveillance.

Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011

“…Production of other carbapenemases and non-carbapenemase-mediated mechanisms were also detected, but remained in the background. However, continuous surveillance should be enforced, considering a recent outbreak caused by NDM-1-producing K. pneumoniae [18].…”

“…In Europe, individual cases or outbreaks of CRE have been reported in several countries [6] but data from the EARS-NET database show that, until 2009, the proportion of CRE has remained overall low in most countries except Greece and Cyprus, where high-level endemicity of carbapenem-nonsuscetible Klebsiella pneumoniae has been reported since the mid-2000s [10]. In Italy, sporadic cases or outbreaks caused by CRE of various species and with different resistance mechanisms have been reported since the early 2000s [11][12][13][14][15][16][17][18][19][20][21][22][23][24], but only since 2010 an abrupt and notable increase in the proportion of carbapenem-non-susceptible K. pneumoniae has ben reported by the EARS-NET surveillance system [10]. This trend has recently been confirmed by data from the Micronet sentinel surveillance network [25].…”

Isolation of bla NDM -producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil

“…Enterobacteria that carry resistance gene to carbapenems, including bla NDM , are considered an important public health problem because of the possibility of expansion of the genes and the clinical impact on the management of infections associated with these microorganisms, which are typically resistant to almost all antibiotics. 12 …”

Επιδημιολογική μελέτη και διερεύνηση πλασμιδιακών AmpC β-λακταμασών και καρβαπενεμασών στα εντεροβακτηριοειδή στην ελληνική επικράτεια

“…Την αρχική εµφάνιση του ενζύµου στην ινδική/πακιστανική χερσόνησο ακολούθησε η επιτυχής παγκόσµια διασπορά του µε αναφορές από την Αγγλία και άλλες Ευρωπαϊκές χώρες, Ρωσία, Καναδά, Αυστραλία, Βόρια και Νότια Αµερική, Νέα Ζηλανδία, Κίνα, Ταιβάν και την Αραβική Χερσόνησο (Ageevets et al, 2014;Bushnell et al, 2013;Johnson and Woodford, 2013;Kumarasamy et al, 2010;Liu et al, 2014;Patel and Bonomo, 2013;Wang et al, 2013). Στην Ευρώπη οι επιδηµίες παραµένουν λίγες και µε περιορισµένο αριθµό περιστατικών (Decousser et al, 2013;Gaibani et al, 2011;Koo et al, 2012;Poirel et al, 2014). Εκτός από την ινδική/πακιστανική χερσόνησο, τα Βαλκάνια αποτελούν µια περιοχή εντός του Ευρωπαϊκού χώρου που ενδέχεται να υποκρύπτει ένα δεύτερο θύλακα διασποράς καθώς τα περιστατικά που έχουν αναφερθεί δεν συσχετίστηκαν µε περιοχές γνωστής ενδηµικότητας (Gecaj-Gashi et al, 2011;Nordmann et al, 2011a;Patel and Bonomo, 2013;Struelens et al, 2010).…”