Outbreak of Pichia kudriavzevii fungaemia in a neonatal intensive care unit

Nagarathnamma, T; Chunchanur, Sneha K; Rudramurthy, Shivaprakash M.; Vineetha, K. R.; Ramamurthy, Karthik; Jillwin, Joseph; Ambica, R.

doi:10.1099/jmm.0.000645

Cited by 23 publications

(19 citation statements)

References 22 publications

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“…13) Although C. albicans is the most prevalent species involved in mucocutaneous and disseminated infections, the incidence of candidiasis due to non-albicans Candida spp. is increasing, [57][58][59][60][61][62][63] among which C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei are the major isolates. These species are inherently resistant or acquire resistance, or both, to commonly used antifungal drugs, such as fluconazole, and, thus, the identification of species of Candida is important for selecting therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

“…anamorph) of the corresponding sexual form (teleomorph) of P. kudriavzevii. Strains of P.kudriavzevii are recognized as fermenting, not pathogenic, fungi, are widely distributed in nature, and are often encountered in spontaneous fermentations and used to produce traditional fermented foods [61][62][63][64]. Recent studies strongly suggested that clinical andBiological and Pharmaceutical Bulletin Advance Publicationenvironmental strains are similar.…”

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confidence: 99%

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Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

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Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as the hot water extract of C. albicans (CADS) and Candida water-soluble fraction (CAWS), induced coronary vasculitis similar to KD in mice. An increasing proportion of deep-seated candidiasis cases are caused by non-albicans Candida and are often resistant to antifungal drugs. We herein investigated whether the hot water extract of C. krusei, inherently resistant to fluconazole, induces vasculitis in mice. Three strains of C. krusei, NBRC1395, NBRC1162, and NBRC10737, were cultured in natural (Y) and chemically defined (C) media and cell wall mannoprotein (MN) fractions were prepared by autoclaving cells (CKY1395MN, CKC1395MN, CKY1162MN, CKC1162MN, CKY10737MN, and CKC10737MN). All MN fractions reacted strongly with Con A and dectin-2 and induced anaphylactoid shock in ICR mice. MNs induced severe coronary vasculitis in DBA/2 mice, resulting in cardiac hypertrophy. MNs also induced coronary vasculitis in C57Bl/6 mice. These results suggest that the MNs of non-albicans Candida, such as C. krusei, induce similar toxicity to those of C. albicans.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

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“…Here, we utilized the most robust and reproducible typing method, FAFLP technique to establish genetic relatedness among blood and environmental isolates. Previously, we reported the effectiveness of AFLP in determining genetic relatedness of isolates due to other fungi from our centre [8,9,29,[34][35][36]. Clustering of environmental isolates with the majority of the blood isolates indicates the hospital environment as the major source of infection.…”

Section: Discussionmentioning

confidence: 94%

Prolonged Outbreak of Candida krusei Candidemia in Paediatric Ward of Tertiary Care Hospital

et al. 2020

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Background A sudden rise of Candida krusei candidemia cases was noticed in our hospital within 1 year with maximum cases from paediatric unit. The present study reports the results of epidemiological investigation of possible outbreak of candidemia by C. krusei in paediatric unit at our tertiary care centre. Methods Clinical characteristics and risk factors associated with C. krusei candidemia were evaluated. Yeast identification and antifungal susceptibility testing was performed according to standard protocol. To find the potential source of C. krusei in hospital environment and hand colonization, swabs were collected from different fomites (n = 40) and hand washings from 24 health care workers (HCW), respectively. Infection control and prevention practices were intensified following the recognition of outbreak. Genetic typing was done by fluorescent amplified fragment length polymorphism (FAFLP) technique. Case-control comparison was performed with C. tropicalis and C. pelliculosa cases.

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“…Non-albicans Candida or other species including Pichia kudriavzevii, Kodamaea ohmeri Candida tropicalis or Cryptococcus albidus have been more frequently isolated from hospitalized patients [1,2,3,4,7,9]. These species seem to be very virulent and often show resistance to the commonly used antifungal treatments [5,7,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…In order to find yeast species which are able to inhibit cell division of the disease-associated species, such as Pichia kudriavzevii, Kodamaea ohmeri, Candida tropicalis, Cryptococcus albidus [1,2,3,4,5,6,7,8], several yeasts were investigated. The test yeast strains were divided into two groups.…”

Section: Metschnikowia Andauensis Pichia Anomala Candida Tropicalismentioning

confidence: 99%

Yeasts are able to inhibit growth of disease-associated fungi

Horváth

Sipiczki

Csoma

et al. 2019

Preprint

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Background Fungal sepsis is often caused by non-albicans Candida or other species. These disease-associated species have strong virulence and often show resistance to the commonly used antifungal treatments. Therefore, finding new inhibitory agents nowadays is increasingly urgent.Results Our screening revealed that although the pathogenic fungi were much more tolerant to yeast-produced bioactive agents than the non-disease-associated yeasts, growth of Kodamaea ohmeri and Candida tropicalis could be inhibited by Metschnikowia andauensis , while Cryptococcus albidus can be controlled by Pichia anomala and Candida tropicalis. The size of the inhibitory zone formed by yeasts was depended on media, pH and temperature. However, extensive studies were carried out, we failed to find inhibitory yeast against Pichia kudriavzevii, suggesting that it must have high natural resistance.Conclusions Certain yeast species can contribute to the future solutions of problems caused by fungal resistance and can be good candidates for finding new bioactive agents which inhibit growth of disease-associated fungi.

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Outbreak of Pichia kudriavzevii fungaemia in a neonatal intensive care unit

Abstract: This study emphasizes the importance of accurate identification of the aetiological agent of sepsis and vigilant monitoring for the possibility of an outbreak in NICUs.

Cited by 23 publications

References 22 publications

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Prolonged Outbreak of Candida krusei Candidemia in Paediatric Ward of Tertiary Care Hospital

Yeasts are able to inhibit growth of disease-associated fungi

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