Outbreak of pneumococcal disease in a nursing home in Spain

Guimbao, Joaquín; Vergara, A; García-Montero, J I; Alberto, Jorge; Lázaro, A. M.; Varona, Wenceslao; Aldea, Juan José Poza; Aspíroz, Carmen; Toledo, Mariana Tâmara Teixeira de

doi:10.2807/esw.06.09.02034-en

Cited by 3 publications

(4 citation statements)

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“…Of the 42 outbreaks reported, 24 occurred in the USA, 10,11,13,14,25,26,38,39,42,44 10 in the UK, 9,12,15,17,20,21,24,33,36 three in Canada, 30 two in France 28,35 and one each in Israel, 34 the Netherlands 32 and Spain. 27 The majority of outbreaks 14 occurred in hospital settings 12,13,15,20e22,31e34,36,43,45 followed by long term care facilities (LTCF) in which 12 were reported. 10,14,25e 27,38,39,42,44,46 Five outbreaks of serious pneumococcal disease in household settings were reported in three papers, 17,24,30 three papers reported pneumococcal outbreaks of S. pneumoniae in child care settings 16,18,40 and three further papers reported four outbreaks involving military personnel.…”

Section: Resultsmentioning

confidence: 98%

“…27,38 In eight of the 12 outbreaks pneumococcal polysaccharide vaccine (PPV) coverage was reported among the population living in the facility 14,25,38,39,42,44,48 ; coverage was less than 10% in six. 11,25,38,39,42 In the other two outbreaks 14,44 PPV coverage was 58% and 49%, respectively.…”

Section: Outbreaks Of Serious Pneumococcal Disease In Hospitalsmentioning

confidence: 99%

“…Nasopharyngeal swabbing of residents and staff was undertaken in five of the 12 reported outbreaks 14,27,38,39,42 leading to the identification of carriers of the same strain among patients in three of these outbreaks 14,38,39 and among staff in two of them. 27,38 In eight of the 12 outbreaks pneumococcal polysaccharide vaccine (PPV) coverage was reported among the population living in the facility 14,25,38,39,42,44,48 ; coverage was less than 10% in six.…”

Section: Outbreaks Of Serious Pneumococcal Disease In Hospitalsmentioning

confidence: 99%

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Outbreaks of serious pneumococcal disease in closed settings in the post-antibiotic era: A systematic review

Ihekweazu¹,

Basarab²,

Wilson³

et al. 2010

Journal of Infection

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Section: Resultsmentioning

confidence: 98%

Section: Outbreaks Of Serious Pneumococcal Disease In Hospitalsmentioning

confidence: 99%

Section: Outbreaks Of Serious Pneumococcal Disease In Hospitalsmentioning

confidence: 99%

See 1 more Smart Citation

Outbreaks of serious pneumococcal disease in closed settings in the post-antibiotic era: A systematic review

Ihekweazu¹,

Basarab²,

Wilson³

et al. 2010

Journal of Infection

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“…In other contexts, such as nursing homes, more adult-adult transmission likely occurs as this would explain nursing home based pneumococcal disease outbreaks. 45 To adequately investigate this however, the establishment and appropriate application of more sensitive methods for pneumococcal carriage surveillance are imperative. Despite some limitations, the results of our study contribute to our understanding of pneumococcal carriage and can inform future policy decisions and preventive strategies aimed at reducing pneumococcal disease burden in children and adults.…”

Section: Discussionmentioning

confidence: 99%

Contact with young children is a major risk factor for pneumococcal colonization in older adults

Wyllie,

Yolda-Carr,

Hislop

et al. 2024

Preprint

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BackgroundImportant questions remain about the sources of transmission of pneumococcus to older adults in the community. This is a critical question for understanding the potential indirect effects of using pneumococcal conjugate vaccines (PCVs) in children and older adults. For non-institutionalized individuals, the most likely source of adult-to-adult transmission is in the household. The goal of this study was to characterize the dynamics and risk factors for acquisition of pneumococcus in older adults.MethodsWe designed a longitudinal study to sample adults >60 years of age living in the same household (New Haven, CT, USA), and without younger contacts residing in the household. Saliva samples and questionnaires regarding social behaviors and health status were obtained every 2 weeks for a period of 10 weeks. DNA extracted from culture-enriched saliva was tested using qPCR for pneumococcus genespiaBandlytA.ResultsAcross two study seasons (November 2020-August 2021, November 2021-September 2022), 121 individuals from 61 households were followed for 6 study visits; 62 individuals were enrolled in both seasons. Overall, 52/1088 (4.8%) samples tested positive for pneumococcus based onpiaB, with 27/121 (22.3%) individuals colonized on at least one time point. Several individuals were colonized at multiple timepoints including two individuals who were colonized throughout the 10-week sampling period; two others were colonized at 5 of 6 time points. In 5 instances, both members of the household were carriers in the same season, though not necessarily at the same time point. Pneumococcal carriage was substantially higher among individuals who had contact with children (10.0% vs 1.6%). Participants who reported recent contact with <5-year-olds and 5-9-year-olds had particularly elevated prevalence (13.8%; 14.1%, respectively).ConclusionsContact with young children was the most important factor that influenced pneumococcal acquisition rates. While there were several instances where both adult household members were colonized at the same time or at sequential visits, these individuals also both typically had contact with children.

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Contact with young children is a major risk factor for pneumococcal colonization in older adults

Wyllie,

Yolda-Carr,

Hislop

et al. 2024

FEMS Microbes

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Background Important questions remain about the sources of transmission of pneumococcus to older adults in the community. This is critical for understanding the potential effects of using pneumococcal conjugate vaccines (PCVs) in children and older adults. For non-institutionalized individuals, we hypothesized that the most likely source of adult-to-adult transmission is within the household. Methods We designed a longitudinal study to sample adults ≥60 years of age living in the same household (New Haven, CT, USA), without younger residents in the household. Saliva samples and social and health questionnaires were obtained every 2 weeks for a period of 10 weeks. DNA extracted from culture-enriched saliva was tested using qPCR for pneumococcus genes piaB, lytA, and serotype. Results Across two study seasons (November 2020-August 2021, November 2021-September 2022), 121 individuals from 61 households completed all 6 visits; 62 individuals were enrolled in both seasons. Overall, 52/1088 (4.8%) samples tested positive for pneumococcus, with 27/121 (22.3%) individuals colonized at least once. Several individuals were colonized at multiple timepoints; two individuals were colonized at 5/6 time points and two at all six. In 5 instances, both household members were carriers in the same season, though not necessarily at the same time. Pneumococcal carriage was substantially higher among individuals who had contact with children (10.0% vs 1.6%). Conclusions Contact with young children was the most important factor that influenced pneumococcal acquisition rates. While there were several instances where both adult household members were colonized at the same time or at sequential visits, these individuals typically had contact with children. As such, PCV immunization can directly protect older adults who have contact with children.

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Outbreak of pneumococcal disease in a nursing home in Spain

Cited by 3 publications

References 0 publications

Outbreaks of serious pneumococcal disease in closed settings in the post-antibiotic era: A systematic review

Outbreaks of serious pneumococcal disease in closed settings in the post-antibiotic era: A systematic review

Contact with young children is a major risk factor for pneumococcal colonization in older adults

Contact with young children is a major risk factor for pneumococcal colonization in older adults

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