Outbreak of postoperative empyema caused by Serratia marcescens in a thoracic surgery unit

Ulu-Kılıç, Ayşegül; Parkan, Ömür Mustafa; Ersoy, Safiye; Koc, D.; Perçin, Duygu; Önal, Ömer; Metan, Gökhan; Alp, Emine

doi:10.1016/j.jhin.2013.07.008

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Serratia marcescens were isolated mainly from male patients with 60 or more years of age, similarly to previous studies that demonstrated advanced age male patients as presenting a higher risk of contracting S. marcescens infections (Ulu-Kilic et al, 2013;Kim et al, 2015;O'Horo et al, 2017). Samples with higher amounts of S. marcescens were those from tracheal aspirate, followed by blood, rectal swab, and wounds.…”

Section: Discussionsupporting

confidence: 82%

Characterization of KPC-Producing Serratia marcescens in an Intensive Care Unit of a Brazilian Tertiary Hospital

et al. 2020

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Serratia marcescens has emerged as an important opportunistic pathogen responsible for nosocomial and severe infections. Here, we determined phenotypic and molecular characteristics of 54 S. marcescens isolates obtained from patient samples from intensive-care-unit (ICU) and neonatal intensive-care-unit (NIUC) of a Brazilian tertiary hospital. All isolates were resistant to beta-lactam group antibiotics, and 92.6% (50/54) were not susceptible to tigecycline. Furthermore, 96.3% showed intrinsic resistance to polymyxin E (colistin), a last-resort antibiotic for the treatment of infections caused by MDR (multidrug-resistant) Gram-negative bacteria. In contrast, high susceptibility to other antibiotics such as fluoroquinolones (81.5%), and to aminoglycosides (as gentamicin 81.5%, and amikacin 85.2%) was found. Of all isolates, 24.1% were classified as MDR. The presence of resistance and virulence genes were examined by PCR and sequencing. All isolates carried KPC-carbapenemase (bla KPC) and extended spectrum beta-lactamase bla TEM genes, 14.8% carried bla OXA−1 , and 16.7% carried bla CTX−M−1group genes, suggesting that bacterial resistance to β-lactam antibiotics found may be associated with these genes. The genes SdeB/HasF and SdeY/HasF that are associated with efflux pump mediated drug extrusion to fluoroquinolones and tigecycline, respectively, were found in 88.9%. The aac(6)-Ib-cr variant gene that can simultaneously induce resistance to aminoglycoside and fluoroquinolone was present in 24.1% of the isolates. Notably, the virulence genes to (i) pore-forming toxin (ShlA); (ii) phospholipase with hemolytic and cytolytic activities (PhlA); (iii) flagellar transcriptional regulator (FlhD); and (iv) positive regulator of prodigiosin and serratamolide production (PigP) were present in 98.2%. The genetic relationship among the isolates determined by ERIC-PCR demonstrated that the vast majority of isolates were grouped in a single cluster with 86.4% genetic similarity. In addition, many isolates showed 100% genetic similarity to each other, suggesting that the S. marcescens that circulate in this ICU are closely related. Our results suggest that the antimicrobial resistance to many drugs

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Section: Discussionsupporting

confidence: 82%

Characterization of KPC-Producing Serratia marcescens in an Intensive Care Unit of a Brazilian Tertiary Hospital

et al. 2020

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“…15 This is like some other studies that showed advanced age male patients as presenting a higher risk of contracting Serratia infections. [16][17][18] In our study, Pus and Tissue specimens yielded maximum number of Serratia Specie which was then followed by blood culture samples, respiratory samples and urine. Sterile fluids including cerebrospinal fluid also accounted for the growth of this dreadful pathogen.…”

Section: Discussionmentioning

confidence: 91%

Antibiotic Sensitivity Pattern of Serratia Species from Clinical Samples at a Tertiary Care Hospital in Rawalpindi

Irfan¹,

Sadiq²,

Amer³

et al. 2022

J. Bahria Uni. Med. Dent. Coll.

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Objective. To determine the antibiotic resistance profile of Serratia spp isolated from various clinical specimens. Study Design and Settings: A descriptive cross-sectional study on antibiotic resistance profile of Serratia spp isolated from various clinical specimens was carried out in the Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi, from 1st July 2017 to 30th June 2021. Methodology: 464 clinical specimens yielding growth of Serratia spp were included in the study. Serratia spp were identified by using Standard Microbiological procedures. Modified Kirby Bauer disc diffusion method was used for Antibiotic Susceptibility testing. The clinical data was analyzed prospectively from July 2017 to June 2021 for a period of 4 years. The spectrum of diseases caused by Serratia spp along with resistance profiles were analyzed. . Data obtained was analysed using SPSS 24. Results: High yield of this bug was obtained from pus and tissue specimens 150 (32%).130(28%) isolates were retrieved from blood cultures, whereas respiratory specimens contributed to 89(19 %) isolates of Serratia spp. According to the antimicrobial susceptibility pattern, 154 (33.3%) isolates were sensitive to Meropenem, 150(32.2%) were susceptible to Doxycycline and 118 (25.5%) to Amikacin, making them the preferred antibiotics to be used in our setup. Conclusion: Serratia marcescens isolates are increasingly resistant to antibiotics. Clinical isolates of Serratia exhibited highest resistance to Ciprofloxacin, Ceftriaxone, Gentamicin and Piperacillin/tazobactam

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“…After removal of the gastroscope and establishment of safe practices, the outbreak stopped [148]. • Serratia marcescens caused increased number of patients with postoperative empyema at a thoracic-surgical intensive care unit in March 2013 in Turkey [149]. The common source of infection was a portable suction machine.…”

Section: Routine Errors Accidents and Failuresmentioning

confidence: 99%

Prevention of Postoperative Wound Infections

Andersen

2019

Prevention and Control of Infections in Hospitals

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Surgery creates most hospital infections, injuries, accidents, invalidity and death in the global healthcare system. The number of surgically treated patients per year is high and increasing. Surgical site infection (SSI) is dependent on type of operation and may occur in 5-20% after surgery, triggers 7-11 extra postoperative days in hospitals and results in 2-11 times higher risk of death than comparable, noninfected patients. Up to 60% of SSI can be prevented. Prevention of postoperative wound infection is done by good general hygiene, operative sterility and effective barriers against transmission of infections, before, during and after surgery. A basic support by hospital leaders, knowledge and skill of the surgical teams, enough resources, excellent treatment of the complete patient admission and monitoring patients after discharge may lead to significant reduction of SSIs, lower death rates and a less expensive health system.

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Outbreak of postoperative empyema caused by Serratia marcescens in a thoracic surgery unit

Cited by 9 publications

References 10 publications

Characterization of KPC-Producing Serratia marcescens in an Intensive Care Unit of a Brazilian Tertiary Hospital

Characterization of KPC-Producing Serratia marcescens in an Intensive Care Unit of a Brazilian Tertiary Hospital

Antibiotic Sensitivity Pattern of Serratia Species from Clinical Samples at a Tertiary Care Hospital in Rawalpindi

Prevention of Postoperative Wound Infections

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