Outbreaks Associated with Contaminated Antiseptics and Disinfectants

Weber, David J.; Rutala, William A.; Sickbert-Bennett, Emily E.

doi:10.1128/aac.00138-07

Cited by 187 publications

(152 citation statements)

References 83 publications

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“…342,343 Many healthcareassociated outbreaks of Burkholderia infections associated with contaminated skin antiseptics, mouthwashes, ultrasound gels, medications, and medical devices have been described. [344][345][346][347][348][349][350][351][352][353][354][355][356][357][358][359][360][361][362] Other products that have become contaminated during use include nasal irrigation bottles contaminated with P. aeruginosa, 363,364 multiuse albuterol vials contaminated with B. cepacia, 348,357 acupuncture devices disinfected with glutaraldehyde contaminated with M. abscessus, 365 cosmetic surgical supplies contaminated with mycobacterial spp., and supplies used for liposuction. 366 Outbreaks of Achromobacter spp.…”

Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 99%

“…Additionally, outbreaks have been related to contamination of this agent. 344 (3) Equipment should be rinsed after use of the cold disinfectant with either sterile water or filtered (less than or equal to 0.2 microns) water, as described above. Sterile water can be prepared by boiling tap water and achieving a rolling boil for 5 minutes.…”

Section: Ive3 Nonhealthcare Settings: Nebulizersmentioning

confidence: 99%

See 1 more Smart Citation

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

Self Cite

352

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 99%

Section: Ive3 Nonhealthcare Settings: Nebulizersmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

Self Cite

352

382

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“…Control III is actually a poor disinfectant because it does not have broad activity, is slow in action, and is associated with pathogenic outbreaks. 26 The Cystic Fibrosis Foundation does not recommend Control III.…”

Section: Manufacturer's Instructions: Are They Compatible With the Gumentioning

confidence: 99%

Device Cleaning and Infection Control in Aerosol Therapy

O'Malley

2015

Respir Care

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Aerosol delivery equipment used to administer inhaled medications includes the nebulizer, positive expiratory pressure devices added to the nebulizer, and valved holding chambers (spacers). These devices are semi-critical medical devices, and as such, infection prevention and control (IPC) guidelines recommend that they be cleaned, disinfected, rinsed with sterile water, and air-dried. There is confusion surrounding the care of aerosol devices because of inconsistencies in the various published IPC guidelines, lack of a standard of practice among institutions and respiratory therapists (RTs), and manufacturer's instructions for use of these devices are not always compatible with guidelines or practice. Challenges lie in awareness of IPC guidelines and establishing a standard for the care of aerosol delivery devices among all stakeholders/manufacturers, governments, vendors, and users. The latest IPC guideline from the Cystic Fibrosis Foundation, reviewed and endorsed by the Society for Healthcare Epidemiology of America and the Association for Professionals in Infection Control, has a recommendation for disposable nebulizers and a recommendation for reusable nebulizers. Reusable nebulizers should be cleaned, disinfected, rinsed with sterile water (if using a cold disinfectant), and air-dried between uses. The mouthpiece/mask of disposable nebulizers should be wiped with an alcohol pad, the residual volume should be rinsed out with sterile water after use, and the nebulizer should be replaced every 24 h. The RT plays a significant and responsible role in providing and teaching aerosol therapy to patients. The RT and all stakeholders need to work together to provide a standard of care for the safe use of aerosol delivery devices.

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“…The core of these policies is to determine the appropriate concentrations, implementation methods, and application areas of disinfectants (7,17). Despite all these activities, infection epidemics caused by the wrong use of biocides have still been reported (18,19). In our study, the MIC values and bactericidal activities were determined for a total of 120 strains (82 gram-negative and 38 gram-positive) belonging to 7 bacterial types isolated from patients admitted to the Hacettepe University Adult Hospital.…”

Section: Discussionmentioning

confidence: 99%