Outcome after renal transplantation. Part I: Intellectual and motor performance

Falger, Jutta; Latal, Bea; Landolt, Markus A.; Lehmann, Phaedra; Neuhaus, Thomas J.; Laube, Guido F.

doi:10.1007/s00467-008-0795-0

Cited by 38 publications

(40 citation statements)

References 18 publications

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“…This result differs from those of other studies in which patients under dialysis, especially HD, presented an increased prevalence of psychosocial disturbances [41,48]. Nevertheless, Falger et al [14,52], in a comprehensive evaluation of both HRQOL and psychosocial adjustment in children and adolescents after renal transplant, have recently shown that psychosocial adjustment in this group was impaired when compared to healthy children. Our analysis showed a negative correlation between PedsQL and SDQ scores, suggesting that the presence of behavior and emotional disorders can account for a considerable impairment of HRQOL in children and adolescents.…”

Section: Discussioncontrasting

confidence: 72%

Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease

et al. 2010

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Recent years has seen an increasing interest in the quality of life (QOL) of children with chronic kidney disease (CKD). The objective of this cross-sectional study was to investigate the prevalence of behavioral disorders and to assess the health-related QOL (HRQOL) in 136 patients with CKD. To estimate the prevalence of behavior disorders and analyze HRQOL, we used the Strengths and Difficulties Questionnaire (SDQ) and Pediatric Inventory of Quality of Life (PedsQL) Core Scales as assessment tools for both the patients and caregivers. When compared to healthy controls, the CKD group had significantly lower scores in almost all PedsQL domains. After adjustment, only absence of religion/other religions remained significantly associated with a lower global HRQOL score [odds ratio (OR) 6.2, P=0.009]. Among the parents, two factors remained significantly associated with a lower global HRQOL score: patients' age >10 years (OR 5.4, P=0.033) and absence of religion/other religions (OR 3.2, P=0.038). The CKD group demonstrated a higher proportion of behavioral and emotional disorders in all SDQ domains. There was a negative correlation between the presence of behavior and emotional disorders and HRQOL score (r= -0.552, P<0.001). Our findings suggest the importance of evaluating behavioral and social repercussions of CKD in order to improve the life quality of this pediatric population.

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Section: Discussioncontrasting

confidence: 72%

Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease

et al. 2010

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“…A recent study found cognitive impairment in 49 children after kidney transplantation with a reported Total IQ of M ¼ 83.9, SD ¼ 20.0 (37). Older studies mainly showed deficits regarding nonverbal abilities (38,39). IQs of children after heart transplantation are relative consistently reported to be 10-15 IQ points below nonclinical comparison groups (40,41).…”

Section: Discussionmentioning

confidence: 99%

Cognitive Performance in Pediatric Liver Transplant Recipients

Kaller

Langguth

Petermann

et al. 2013

American Journal of Transplantation

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To date, the course of cognitive development in children after liver transplantation (Ltx) is poorly understood. Cognitive performance, however, is crucial in all developmental stages and for educational achievement. This cross‐sectional single‐center study examined the prevalence of long‐term cognitive impairment in a cohort of 64 pediatric patients after Ltx. Median age at Ltx was 12 months. The revised Wechsler Intelligence Scale IV was administered to assess cognitive performance. Patients were compared with an age‐ and gender‐matched group of children without a chronic health condition. Liver transplanted children performed significantly worse in three of four cognitive domains as well as in the Total Intelligence Quotient (Total IQ) (p = 0.017 to p = 0.005). Liver transplant recipients showed substantially more “serious delays” (IQ < 70) compared to the reference group (9.4% vs. 4.7%). Children with a genetic–metabolic disease performed worse than the other groups in three of the four WISC Indices and in the Total IQ (p = 0.05 to p = 0.01). The strongest association was revealed between height at Ltx and Verbal Comprehension (R2 = 0.21), Perceptual Reasoning (R2 = 0.30), Working Memory (R2 = 0.23) and Total IQ (R2 = 0.25). Our results indicate a high impact of primary diagnosis and height percentile at Ltx even on children's long‐term cognitive performance.

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“…A number of studies have identified lower nonverbal intelligence quotient (IQ) and motor performance in children with kidney disease compared with healthy age-matched controls (6)(7)(8)(9)(10)(11). Some have found no significant differences in memory (verbal and nonverbal) between children with and without CKD (11).…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive and Educational Outcomes in Children and Adolescents with CKD

Chen¹,

Didsbury²,

Zwieten³

et al. 2018

CJASN

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Background and objectives Poor cognition can affect educational attainment, but the extent of neurocognitive impairment in children with CKD is not well understood. This systematic review assessed global and domainspecific cognition and academic skills in children with CKD and whether these outcomes varied with CKD stage.Design, setting, participants, & measurements Electronic databases were searched for observational studies of children with CKD ages 21 years old or younger that assessed neurocognitive or educational outcomes. Risk of bias was assessed using a modified Newcastle-Ottawa scale. We used random effects models and expressed the estimates as mean differences with 95% confidence intervals stratified by CKD stage.Results Thirty-four studies (25 cross-sectional, n=2095; nine cohort, n=991) were included. The overall risk of bias was high because of selection and measurement biases. The global cognition (full-scale intelligence quotient) of children with CKD was classified as low average. Compared with the general population, the mean differences (95% confidence intervals) in full-scale intelligence quotient were 210.5 (95% confidence interval, 213.2 to 27.72; all CKD stages, n=758), 29.39 (95% confidence interval, 212.6 to 26.18; mild to moderate stage CKD, n=582), 216.2 (95% confidence interval, 233.2 to 0.86; dialysis, n=23), and 211.2 (95% confidence interval, 217.8 to 24.50; transplant, n=153). Direct comparisons showed that children with mild to moderate stage CKD and kidney transplants scored 11.2 (95% confidence interval, 2.98 to 19.4) and 10.1 (95% confidence interval, 21.81 to 22.0) fullscale intelligence quotient points higher than children on dialysis. Children with CKD also had lower scores than the general population in executive function and memory (verbal and visual) domains. Compared with children without CKD, the mean differences in academic skills (n=518) ranged from 215.7 to 21.22 for mathematics, from 29.04 to 20.17 for reading, and from 214.2 to 2.53 for spelling.Conclusions Children with CKD may have low-average cognition compared with the general population, with mild deficits observed across academic skills, executive function, and visual and verbal memory. Limited evidence suggests that children on dialysis may be at greatest risk compared with children with mild to moderate stage CKD and transplant recipients.

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Outcome after renal transplantation. Part I: Intellectual and motor performance

Cited by 38 publications

References 18 publications

Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease

Behavioral disorders and low quality of life in children and adolescents with chronic kidney disease

Cognitive Performance in Pediatric Liver Transplant Recipients

Neurocognitive and Educational Outcomes in Children and Adolescents with CKD

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