Outcome after surgery for invasive intraductal papillary mucinous neoplasia compared to conventional pancreatic ductal adenocarcinoma – A Swedish nationwide register-based study

Holmberg, Marcus; Radkiewicz, Cecilia; Strömberg, C.; Öman, Mikael; Ghorbani, Poya; Löhr, Matthias; Sparrelid, Ernesto

doi:10.1016/j.pan.2022.12.003

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…After adjusting for potential confounders using a propensity score-matched analysis, the results showed that the clinical outcomes of iIPMN were still better than those of PDAC. However, subgroup analysis found that the survival differences were not significant in patients with advanced neoplasms (T4, N2, or M1), which is consistent with several recent studies [ 11 , 12 ]. Hence, to improve clinical outcomes, long-term monitoring is crucial for the early detection of iIPMN.…”

Section: Discussionsupporting

confidence: 91%

Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades

Song,

Li,

Cui

et al. 2023

World J Surg Onc

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Purposes Invasive pancreatic cystic neoplasms (iPCNs) are an uncommon and biologically heterogeneous group of malignant neoplasms. We aimed to investigate the clinicopathological characteristics of iPCN patients and to develop nomograms for individual survival prediction after radical surgery. Methods Data of patients diagnosed with iPCN and pancreatic ductal adenocarcinoma (PDAC) between 2000 and 2018 from the SEER database were retrieved. The differences in clinical outcomes were evaluated using the Kaplan–Meier analysis. Nomograms were proposed based on the Cox regression model and internally validated by C-index, area under the curve (AUC) value, and calibration plot. Results A total of 7777 iPCN patients and 154,336 PDAC patients were enrolled. Most neoplasms were advanced, with 63.1% at stage IV. The 3-year overall survival (OS) and cancer-specific survival (CSS) rates in surgical patients were as follows: 45.7% and 50.1% for invasive intraductal papillary mucinous neoplasm (IPMN), 54.8% and 59.3% for invasive mucinous cystic neoplasm (MCN), 97.8% and 98.2% for invasive solid pseudopapillary neoplasm (SPN), 88.9% and 88.9% for invasive serous cystic neoplasm (SCN), and 27.3% and 30.5% for PDAC. Subgroup analyses showed no clinical benefit from chemotherapy or radiotherapy in lymph node-negative iPCN patients who underwent surgery. The following variables associated with OS and CSS were identified: age, race, chemotherapy, radiotherapy, histologic type, pathological grade, regional nodes examined, and T, N, and M stage. The nomograms had good discrimination and calibration by internal validation, with an AUC value of 0.800 for 3-year OS and 0.814 for 3-year CSS. Conclusion Our study showed that the prognosis of iPCN patients was significantly better than PDAC patients. The proposed nomograms demonstrated substantially better discrimination and calibration.

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Section: Discussionsupporting

confidence: 91%

Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades

Song,

Li,

Cui

et al. 2023

World J Surg Onc

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“…IPMNs can be further divided into four subtypes according to histology and MUC expression: intestinal, pancreatobiliary, gastric, and oncocytic type. Over time, some of the IPMN tumors develop increasing grades of dysplasia and transform into an invasive carcinoma, invasive IPMN 1 , 2 . The risk of malignancy depends on the type and the histological subtype of IPMN.…”

Section: Introductionmentioning

confidence: 99%

N-glycosylation in non-invasive and invasive intraductal papillary mucinous neoplasm

Nieminen

Nummela

Satomaa

et al. 2023

Sci Rep

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Intraductal papillary mucinous neoplasms (IPMNs), often found incidentally, are potentially malignant cystic tumors of the pancreas. Due to the precancerous nature, IPMNs lacking malignant features should be kept on surveillance. The follow-up relies on magnetic resonance imaging, which has a limited accuracy to define the high-risk patients. New diagnostic methods are thus needed to recognize IPMNs with malignant potential. Here, aberrantly expressed glycans constitute a promising new area of research. We compared the N-glycan profiles of non-invasive IPMN tissues (n = 10) and invasive IPMN tissues (n = 10) to those of non-neoplastic pancreatic controls (n = 5) by matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry. Both IPMN subgroups showed increased abundance of neutral composition H4N4 and decrease in H3N5F1, increase in sialylation, and decrease in sulfation, as compared to the controls. Furthermore, invasive IPMN showed an increase in terminal N-acetylhexosamine containing structure H4N5, and increase in acidic complex-type glycans, but decrease in their complex fucosylation and sulfation, as compared to the controls. In conclusion, the N-glycan profiles differed between healthy pancreatic tissue and non-invasive and invasive IPMNs. The unique glycans expressed in invasive IPMNs may offer interesting new options for diagnostics.

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Pre-emptive resection for intraductal papillary mucinous neoplasia – Long-term outcome is similar between non-invasive and early invasive lesions in a tertiary single center

et al. 2023

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Outcome after surgery for invasive intraductal papillary mucinous neoplasia compared to conventional pancreatic ductal adenocarcinoma – A Swedish nationwide register-based study

Cited by 6 publications

References 41 publications

Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades

Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades

N-glycosylation in non-invasive and invasive intraductal papillary mucinous neoplasm

Pre-emptive resection for intraductal papillary mucinous neoplasia – Long-term outcome is similar between non-invasive and early invasive lesions in a tertiary single center

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