Introduction: Heavy menstrual bleeding (HMB) or menorrhagia is the most common form of dysfunctional uterine bleeding (DUB). In spite of medical treatment for DUB, many women will eventually require a hysterectomy, which is an invasive treatment option. NovaSure ablation offers a same-day non-invasive alternative to hysterectomy and hysteroscopic ablation. Case description: A 38-year-old woman presented with HMB in 2015. The attacks of HMB interrupted her lifestyle , and she refused to continue with medical treatment, which failed to resolve her symptoms. The patient was admitted to the hospital four times in 2015, due to anemia caused by the DUB. Medroxyprogesterone acetate and oral contraceptive pills failed to control the patient's bleeding episodes. Hysteroscopic examination of the uterine cavity showed a normal cavity, and the endometrial biopsy showed proliferative endometrium. She was counseled about NovaSure ablation as the last treatment option before hysterectomy. The NovaSure ablation procedure took 90 s, and the patient was discharged from the hospital 6 h after the procedure. At follow-up, the patient is completely amenorrheic, and she is satisfied with the NovaSure ablation results. Conclusions: This case report demonstrates that NovaSure endometrial ablation is a safe, effective, non-invasive alternative to hysteroscopic endometrial ablation for treatment of DUB.