Outcome and medical management in dogs with lower motor neuron disease undergoing mechanical ventilation: 14 cases (2003–2009)

Abstract

High euthanasia rates and iatrogenic complications limit the ability to accurately prognosticate for affected dogs in this retrospective study, but in dogs with LMND that is severe enough to require IIPV, support may be required days to weeks.

A retrospective study of positive pressure ventilation in 58 dogs: indications, prognostic factors and outcome

“…In previous veterinary reports, dogs undergoing PPV due to inadequate ventilation had a higher survival rate compared with those with oxygenation failure (King et al ; Campbell et al ; Beal et al ; Vasillev et al ; Lee et al ; Hopper et al ; Rutter et al ). Among the aetiologies in dogs with PPD in the present study, dogs with pulmonary contusions showed the highest survival rate, as previously reported (Hopper et al ).…”

“…The indications for PPV include pulmonary parenchymal disease (PPD), which results in inadequate blood oxygenation and ventilatory failure, leading to inadequate pulmonary carbon dioxide elimination (Mellema et al , Clare et al , Hopper et al ). The survival rates of ventilated human and veterinary patients with oxygenation or ventilatory failures are 20 to 30% and 50 to 70%, respectively (King et al , Macintyre , Campbell et al , Beal et al , Meade et al , Brower et al , Vasillev et al , Lee et al , Boles et al , Hopper et al , Esteban et al , Rutter et al ).…”

Anti‐GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis

“…Both GBS and ACP are characterized by a bilateral symmetrical ascending weakness of the limbs which can culminate in a generalized paralysis and require the patient to be ventilated (Winer , ; Cuddon , ; Rutter et al ., ) . Additionally, an involvement of CNs VII, X, or XII might be observed (Cummings and Haas , ; Asbury et al ., ; Northington and Brown , ; McKhann et al, 1991; van Doorn et al ., ) .…”

Diseases of the Motor Unit

“…However, treatment with human IV immunoglobulin may shorter its clinical course. 22 Close observation for respiratory muscle paresis is important, and the patient may require intubation and mechanical ventilation if the respiratory function becomes severely compromised (see Chapter 30).…”