Outcome and Predictors of Treatment Failure in Total Hip/Knee Prosthetic Joint Infections Due to Staphylococcus aureus

Senneville, Éric; Joulie, Donatienne; Legout, L.; Valette, M.; Dezèque, Hervé; Beltrand, E.; Roselé, Bernadette; d’Escrivan, Thibaud; Loïez, Caroline; Caillaux, M.; Yazdanpanah, Yazdan; Maynou, C.; Migaud, Henri

doi:10.1093/cid/cir402

Cited by 226 publications

(184 citation statements)

References 32 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…This success rate corresponds closely to those cited in the current literature, where similar studies report rates of 67 % and 94 % [12][13][14][15][16]. However, being so diverse, these studies are difficult to compare.…”

Section: Discussionsupporting

confidence: 88%

Periprosthetic joint infection—effect on quality of life

Helwig

Morlock

Oberst

et al. 2014

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Purpose Relatively little is known about the extent to which periprosthetic joint infections (PJI) affect the patient's longterm quality of life (QoL). Our study aim was to assess the effect of a periprosthetic infection on our patients' QoL. Methods We collected data retrospectively of patients who had undergone surgery in our institution between 2006 and 2011. To capture their overall QoL, we telephoned the patients who could be reached and asked them the questions on the SF-12 questionnaire. Results In 84 patients (53 male, 31 female, 43 TKA and 41 THA), 88 % of the hip infections and 62 % of the knee infections had been successfully treated. The hip infections' cure rate was significantly higher than that of the knee joint infections.The average SF-12 score was 36.2 points on the physical scale and 52 on the mental scale. The difference in QoL between patients with and without successful infection therapy was not significant, nor did the site of the infection (knee or hip) influence QoL significantly.Comparison of our patients' QoL data to that from the general population revealed a significant difference in the physical scale but not the mental scale. Conclusion From these results QoL is substantially reduced after a prosthetic infection. We did however observe that postGirdelstone procedure patients or those with an arthrodesis attained an acceptable QoL, and that those methods remain therapeutic alternatives as far as patient-perceived QoL is concerned.

show abstract

Section: Discussionsupporting

confidence: 88%

Periprosthetic joint infection—effect on quality of life

Helwig

Morlock

Oberst

et al. 2014

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…For this reason, it is considered the drug of choice for the treatment of S. aureus PJI in combination with an appropriate anti-staphylococcal agent to prevent acquisition of resistance [1,2]. However, little data has clearly demonstrated the superiority of rifampicin-based regimens in comparison with other combinations in patients presenting with S. aureus PJI, and there is a debate on the adequate dose for patients presenting with PJI [9,[14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure

Bouaziz

Uçkay

Lustig

et al. 2018

Médecine et Maladies Infectieuses

View full text Add to dashboard Cite

Please cite this article in press as: Bouaziz A, et al. Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure. AbstractObjective. -The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known.Patients and methods. -Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure.Results. -Eighty-nine patients with a mean follow-up of 2.8 years were included. Non-compliance with IDSA surgical guidelines was associated with treatment failure (hazard ratio 2.157; 95% CI [1. 022-4.7]). The American Society of Anesthesiologists score, inadequate antimicrobial therapy, and a rifampicin-based regimen did not significantly influence patient outcome.Conclusion. -Based on the IDSA guidelines, if a patient presenting with MSSA PJI is not eligible for implant retention, complete implant removal is needed to limit treatment failure.

show abstract

“…The majority of implanted medical device infections are caused by staphylococcal species, including methicillin-resistant Staphylococcus aureus (MRSA) (1,2,4). Systemic administration of vancomycin (Van) plus rifampin (Rif) is recommended in clinical practice guidelines to treat these infections (14-16) because combinatorial therapy with Rif has an added therapeutic benefit (27,28). Newer antistaphylococcal agents such as linezolid (Lin) and daptomycin (Dap) are also used to cover MRSA (29).…”

Section: Resultsmentioning

confidence: 99%

Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo

Ashbaugh

Jiang

Zheng

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Bacterial biofilm formation is a major complication of implantable medical devices that results in therapeutically challenging chronic infections, especially in cases involving antibiotic-resistant bacteria.As an approach to prevent these infections, an electrospun composite coating comprised of poly(lactic-coglycolic acid) (PLGA) nanofibers embedded in a poly(e-caprolactone) (PCL) film was developed to locally codeliver combinatorial antibiotics from the implant surface. The release of each antibiotic could be adjusted by loading each drug into the different polymers or by varying PLGA:PCL polymer ratios. In a mouse model of biofilm-associated orthopedic-implant infection, three different combinations of antibiotic-loaded coatings were highly effective in preventing infection of the bone/joint tissue and implant biofilm formation and were biocompatible with enhanced osseointegration. This nanofiber composite-coating technology could be used to tailor the delivery of combinatorial antimicrobial agents from various metallic implantable devices or prostheses to effectively decrease biofilm-associated infections in patients.nanofiber | biofilm | infection | antibiotic | delivery

show abstract

Outcome and Predictors of Treatment Failure in Total Hip/Knee Prosthetic Joint Infections Due to Staphylococcus aureus

Abstract: The results of the present study suggest that ASA score ≤ 2 and use of rifampin-combination therapy are two independent factors associated with favorable outcome of patients treated for total hip or knee prosthetic infections due to S. aureus.

Cited by 226 publications

References 32 publications

Periprosthetic joint infection—effect on quality of life

Periprosthetic joint infection—effect on quality of life

Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure

Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo

Contact Info

Product

Resources

About