Outcome and prognosis in retroperitoneal soft tissue sarcoma

Catton, Charles; O’Sullivan, Brian; Kotwall, Cyrus A.; Cummings, Bernard; Hao, Yong; Fornasier, Victor

doi:10.1016/0360-3016(94)90395-6

Cited by 264 publications

(158 citation statements)

References 11 publications

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“…[2][3][4][5][6][7][8][9][10] In many series, the quality of surgery was the only significant prognostic factor for survival; therefore, extensive surgery has been advocated strongly. [2][3][4][5][6][7][8][9][10] However, even in series that produced excellent rates of resection, the local recurrence rate remained high. This most likely is related to the difficulty of ensuring truly tumor free margins in retroperitoneal sarcomas, no matter how experienced the surgeon.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of patients with STS generally is poor, especially when they are assessed over the long term. [2][3][4][5][6][7][8][9][10] The contribution of adjuvant chemotherapy to the treatment of adult patients with STS remains questionable, whereas radiation therapy in patients with retroperitoneal STS is either unfeasible or is affected strongly by anatomic constraints (mainly related to the presence of kidneys and small bowel). Therefore, the main therapeutic burden is placed on surgery.…”

mentioning

confidence: 99%

“…Therefore, the main therapeutic burden is placed on surgery. [2][3][4][5][6][7][8][9][10] However, surgery alone is curative in only a relatively small number of patients. Available studies vary widely with regard to estimates of cured or long-term survivors, most likely depending on strong variations in the referral pattern of the various institutions.…”

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confidence: 99%

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Retroperitoneal soft tissue sarcomas

Gronchi

Casali

Fiore

et al. 2004

Cancer

160

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BACKGROUNDThe objective of this study was to assess long‐term prognosis and patterns of failure in patients with retroperitoneal soft tissue sarcoma who underwent surgery with curative intent at a single institution. Several series of patients with retroperitoneal sarcoma were reported, providing widely variable data regarding local and distant failure.METHODSOverall, 167 consecutive patients who underwent surgery for retroperitoneal soft tissue sarcoma over a 20 year span at a single referral center were reviewed retrospectively. Eighty‐two patients presented with primary disease, whereas 85 patients had recurrent locoregional tumors. Surgical resection was considered macroscopically complete in 147 of 167 patients (88%).RESULTSOverall survival at 10 years after definitive surgery was approximately 27%, and the disease‐free survival was approximately 16%. Only a minority of patients developed distant metastases. The risk of recurrence was correlated with whether patients underwent surgery for primary disease or for recurrent disease; the 10 year disease‐free survival rate was 27% in the former group and 4.6% in the latter group. Histotype and malignancy grade were other prognostic factors, with the former found to be predictive of the pattern of failure and the latter predictive of overall survival.CONCLUSIONSLocal recurrence after primary surgery and high‐grade malignancy were associated with the worst survival. Histologic subtype appeared to influence the pattern of recurrence, which mainly was local for patients with liposarcoma but was both local and distant for patients with the other histotypes. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Retroperitoneal soft tissue sarcomas

Gronchi

Casali

Fiore

et al. 2004

Cancer

160

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“…Retroperitoneal leiomyosarcoma occurs most commonly in [2][3][4][5] the fifth to seventh decade. Retroperitoneal tumors typically have vague presenting symptoms.…”

Section: Schwarzbach Mh Et Almentioning

confidence: 99%

“…Leiomyosarcoma 1 consists of 5% to 10% of all soft tissue sarcoma. 10% to 20% [2][3][4][5][6] of soft tissue sarcomas occur in the retroperitoneum. In a population-based series reported in the Surveillance, Epidemiology, and End Results (SEER) database, the average annual incidence of retroperitoneal sarcomas was 7 approximately 2.7 cases per million population.…”

Section: Introductionmentioning

confidence: 99%

Unusual Case of Retropancreatic Mass Involving Portal Vein

Poudel

Adhikari

Basnet

et al. 2018

J Univ Coll Med Sci

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Retroperitoneal Tumors are relatively rare and usually present in locally advanced stage. They present special therapeutic challenges because of their location and frequent intimate association with major vessels in retroperitoneum. Herein, we present a case report of a patient with retropancreatic mass along with features of portal hypertension in CT scan.Intraoperatively tumor was adhered to portal vein, resection and anastomosis of Portal Vein with excision of tumor was done. Leiomysarcoma was diagnosed after histopathology and immunohistochemistry report.

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