Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study)

Association between plasma-free hemoglobin levels, lactate dehydrogenase and hemolysis-index in patients with and without mechanical circuit support - a retrospective data analysis

“…LDH is an enzyme existing in multiple cell types and serum levels rise in acute phase reactions as well as following lysis or necrosis not only of blood cells but of any cell in the body, therefore multiple reasons for LDH increases exist in patients after operative procedures or during critical illness. [11][12][13] Our cost analysis showed a relevant cost e ciency of HI over fHb in ICU patients on ECLS 4.347.25 (794.21-5350.46) USD per ECLS patient due to a median number of 104 measurements performed per patient. Thus, in a ctional 10 bed ICU with 2 patients being on ECLS (4 daily measurements) and 8 patients without ECLS support (1 daily measurements), preferring HI over fHb would save 20.064.24 USD per month and preferring HI over LDH measurements would save 1.769.04 USD per month.…”

“…15 Unlike fHb and LDH, HI is not routinely displayed as a lab result since it is considered an internal parameter evaluating the preanalytical condition of blood samples but can be made readily available for clinicians free of charge. [11][12][13] Previous investigations show good correlation of several quantitative and qualitative measurements of various analytical devices measuring HI to fHb concentrations in healthy volunteers or arti cial plasma. 14,16,17 Bosma et.…”

“…Lactate dehydrogenase (LDH) is an intracellular enzyme involved in the conversion of lactate to pyruvate which is released into the serum when erythrocytes or other cells undergo lysis and thus levels of LDH have been associated with clinically signi cant hemolysis in patients suffering from hematological or infectious diseases. [11][12][13] HI and fHb are unavailable in situations with very high serum bilirubin since hyperbilirubinemia interferes with photospectrometic HI and fHb measurement by altering light absorption by plasma. Unlike HI and fHb, LDH measurement is performed by measuring its catalytic activity via reduction of NAD to NADH, despite also involving absorption of light of NADH (photospectometry), it is very robust also in severe icterus and lipemia.…”

Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group

“… 4 , 14 Owing to various reasons, some trial groups mainly conducted retrospective studies to review the outcome of standard treatment or report on specific issues related to a treatment protocol, such as complications or late effects. 19 , 25 , 38 Recognizing challenges in accessing care, INPHOG has a subcommittee focused on multicenter research in access to care and is enrolling patients in extensive multicenter studies that are examining out-of-pocket expenditure, pathways to diagnosis, and the effects of COVID-19 on treatment access. The reasons leading to the slow development of clinical trial groups are multifactorial, and some are due to local regulatory issues.…”

Hemolysis Index Correlations with Plasma-Free Hemoglobin and Plasma Lactate Dehydrogenase in Critically Ill Patients under Extracorporeal Membrane Oxygenation or Mechanical Circulatory Support—A Single-Center Study

“…PFH levels serve as a valuable tool for the early detection of subclinical thrombosis [5] and pump thrombosis in patients under ECMO or mechanical circulatory support with VAD [5][6][7][8]. Additionally, plasma LDH levels are used to aid in the identification of hemolysis [9][10][11]. It is important to note that the measurements of both laboratory parameters come at a considerable cost, and the reliability of plasma LDH levels may be compromised in patients with hyperbilirubinemia, a condition often observed in patients undergoing mechanical circulatory support.…”