Outcome and risk factors of hepatic artery thrombosis after orthotopic liver transplantation in adults

El-Ella, K. Abou; Sebayel, Mohammed Al; Ramirez, Carlo B.; Hussien, Rania Maher

doi:10.1016/s0041-1345(01)02157-1

Cited by 26 publications

(26 citation statements)

References 2 publications

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“…In this group of livers, we have demonstrated that pSCS‐NMP is safe and feasible with a 30‐day graft survival rate of 94%. The 6% incidence of acute HAT observed in this study is in keeping with other published series wherein an incidence of up to 9% is quoted . Neither case of HAT appeared to be related to the perfusion process, and the cases are discussed later.…”

Section: Discussionsupporting

confidence: 92%

Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology

et al. 2019

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Clinical adoption of normothermic machine perfusion (NMP) may be facilitated by simplifying logistics and reducing costs. This can be achieved by cold storage of livers for transportation to recipient centers before commencing NMP. The purpose of this study was to assess the safety and feasibility of post–static cold storage normothermic machine perfusion (pSCS‐NMP) in liver transplantation. In this multicenter prospective study, 31 livers were transplanted. The primary endpoint was 30‐day graft survival. Secondary endpoints included the following: peak posttransplant aspartate aminotransferase (AST), early allograft dysfunction (EAD), postreperfusion syndrome (PRS), adverse events, critical care and hospital stay, biliary complications, and 12‐month graft survival. The 30‐day graft survival rate was 94%. Livers were preserved for a total of 14 hours 10 minutes ± 4 hours 46 minutes, which included 6 hours 1 minute ± 1 hour 19 minutes of static cold storage before 8 hours 24 minutes ± 4 hours 4 minutes of NMP. Median peak serum AST in the first 7 days postoperatively was 457 U/L (92‐8669 U/L), and 4 (13%) patients developed EAD. PRS was observed in 3 (10%) livers. The median duration of initial critical care stay was 3 days (1‐20 days), and median hospital stay was 13 days (7‐31 days). There were 7 (23%) patients who developed complications of grade 3b severity or above, and 2 (6%) patients developed biliary complications: 1 bile leak and 1 anastomotic stricture with no cases of ischemic cholangiopathy. The 12‐month overall graft survival rate (including death with a functioning graft) was 84%. In conclusion, this study demonstrates that pSCS‐NMP was feasible and safe, which may facilitate clinical adoption.

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Section: Discussionsupporting

confidence: 92%

Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology

et al. 2019

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“…In only two centers routine DUS was not performed (3,46 (12,27,28,33,42,44,48,51,52,54,62,65,71,84 (12,16,17,21,25,27,28,33,35,(41)(42)(43)(45)(46)(47)(48)(53)(54)(55)57,59,67,(70)(71)(72)(73)80,82,(84)(85)(86)(87) (12,27,28,33,42,…”

Section: Doppler Ultrasound Screening Protocolsmentioning

confidence: 99%

“…7 Only manuscripts mentioning the outcome are included. I 2,12,16,17,21,27,28,30,35,41,42,45,46,48,[51][52][53][54][55][56][57][58][59]61,62,64,65,[67][68][69][70][71][72][73]77,80,82,[84][85][86][87]16,17,21,25,27,28,33,35,[41][42][43]…”

Section: Doppler Ultrasound Screening Protocolsmentioning

confidence: 99%

Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk Factors

Bekker¹,

Ploem

Jong³

2009

American Journal of Transplantation

507

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To clarify inconsistencies in the literature we performed a systematic review to identify the incidence, risk factors and outcome of early hepatic artery thrombosis (eHAT) after liver transplantation. We searched studies identified from databases (MEDLINE, EMBASE, Science Citation Index) and references of identified studies. Seventy-one studies out of 999 screened abstracts were eligible for this systematic review. The incidence of eHAT was 4.4% (843/21, 822); in children 8.3% and 2.9% in adults (p < 0.001). Doppler ultrasound screening (DUS) protocols varied from 'no routine' to 'three times a day.' The median time to detection was at day seven. The overall retransplantation rate was 53.1% and was higher in children (61.9%) than in adults (50%, p < 0.03). The overall mortality rate of patients with eHAT was 33.3% (range: 0-80%). Mortality in adults (34.3%) was higher than in children (25%, p < 0.03). The reported risk factors for eHAT were, cytomegalovirus mismatch (seropositive donor liver in seronegative recipient), retransplantation, arterial conduits, prolonged operation time, low recipient weight, variant arterial anatomy, and low volume transplantation centers. eHAT is associated with significant graft loss and mortality. Uniform definitions of eHAT and uniform treatment modalities are obligatory to confirm these results and to obtain a better understanding of this disastrous complication.

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“…Hepatic artery thrombosis can result in the need for re-transplantation if changes are advanced (Abou El-Ella et al 2001 ;Stringer et al 2001 ). (Fig.…”

Section: Pathologymentioning

confidence: 99%

Pathology of Pediatric Gastrointestinal and Liver Disease

2014

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Outcome and risk factors of hepatic artery thrombosis after orthotopic liver transplantation in adults

Cited by 26 publications

References 2 publications

Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology

Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology

Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk Factors

Pathology of Pediatric Gastrointestinal and Liver Disease

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