Outcome and Status of Microsatellite Stability in Japanese Atomic Bomb Survivors with Early Gastric Carcinoma

Abstract

The prognosis of early gastric cancer in atomic bomb survivors was poor and was related to age and sex, rather than to being an atomic bomb survivor. Furthermore, a higher rate of defective hMSH2 and/or hMLH1 expression was observed in the survivors.

Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

“…Finally, a study investigating clinicopathological and molecular features between MLH1 methylation‐positive and ‐negative MSI gastric cancers was not included. Forty‐eight studies published between 1994 and 2016, with a study interval ranging from 1980 and 2013, were included in the review ( Table S2 , supporting information). The total number of patients included was 18 612, ranging from 24 to 2959 per study.…”

“…Five of 48 studies (637 patients, 3·4 per cent) were multicentre studies from the USA, Canada, Germany, Korea, Poland, Russia, Ukraine, Vietnam, the UK, South Africa, Chile, Colombia and Japan. The other 43 studies were performed in single centres in Eastern populations (15 529 patients, 83·4 per cent) from Japan, China, Korea and Taiwan, or in Western populations (2446 patients, 13·1 per cent) from Italy, Poland, Slovenia, the UK, Portugal, Brazil and Germany.…”

“…Overall, 33 studies used MSI PCR testing alone, five employed immunohistochemistry testing, and ten used both MSI PCR and immunohistochemistry testing to determine MSI status. The overall proportion of patients with MSI was 9·2 per cent (1718 of 18 612), ranging from 5·6 per cent to 33·3 per cent.…”

“…Median follow‐up was 12 to 183·6 months; 30 studies did not clearly specify the duration of follow‐up for survival. Overall survival was reported in 21 studies: 12 reported HRs and 95 per cent confidence intervals for the influence of MSI status in gastric cancer on overall survival, for one study these values were obtained directly from the author, and in one instance the author calculated values from the raw data available from the study author. The HR was estimated from a Kaplan–Meier curve in seven studies.…”

“…The total number of patients included was 18 612, ranging from 24 13 to 2959 25 per study. 30 Bae et al 25 Chuiaravalli et al 53 Cristescu et al 4 Czopek et al 54 Falchetti et al 55 Fang et al 36 Gazvoda et al 56 Giampieri et al 57 Inada et al 37 Kim et al 10 Kim et al 5 Marrelli et al 8 Oki et al 14 Oliveira et al 60 Perez et al 13 Schneider et al 27 Warneke et al 62 Wirtz et al 12 Yamamoto et al 50 Zhao et al 51 Overall effect 42 . As not all studies reported all variables examined in the meta-analysis, only studies reporting the variable of interest were included, in turn, for quantitative synthesis to investigate the association between MSI status and that variable.…”